Organotin Compounds Act as Inhibitor of Transcriptional Activation with Human Estrogen Receptor
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Cho, Eun-Min
(Institute of Green Environmental Research Center, University of Incheon)
Lee, Haeng-Seog (New and Renewable Energy Company, North of Gyeonggi Venture Center) Moon, Jeong-Suk (Green Technology Development Office, Korea Environmental Industry and Technology Institute) Kim, Im-Soon (Graduate School of Environmental Studies, Kwangwoon University) Sim, Sang-Hyo (Department of Occupational Medicine, Hanyang University Medical Center) Ohta, Akinori (Department of Biotechnology, The University of Tokyo) |
1 | Antizar-Ladislao, B. 2008. Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. Environ. Int. 34: 292-308. DOI ScienceOn |
2 | Axiak, V., D. Micallef, J. Muscat, A. Vella, and B. Mintoff. 2003. Imposex as a biomonitoring tool for marine pollution by tributyltin: Some further observations. Environ. Int. 28: 743-749. DOI ScienceOn |
3 | Bettin, C., J. Oehlmann, and E. Stroben. 1996. TBT-induced imposex in marine neogastropods is mediated by an increasing androgen level. Helgol. Meeresun. 50: 299-317. DOI ScienceOn |
4 | Bryan, G. W., F. E. Gibbs, L. G. Hummerstone, and G. R. Burt. 1986. The decline of the gastropod Nucella 321 lapillus around south-west England: Evidence for the effect of tributyltin from anti-fouling paints. J. Mar. Biol. Assoc. UK 66: 611-640. DOI |
5 | Cai, J., M. Wang, B. Li, C. Wang, Y. Chen, and Z. Zuo. 2009. Apoptotic and necrotic action mechanisms of trimethyltin in human hepatoma G2 (HepG2) cells. Chem. Res. Toxicol. 22: 1582-1587. DOI ScienceOn |
6 | Chahomchuen, T., K. Akiyama, T. Sekito, N. Sugimoto, M. Okabe, S. Nishimoto, T. Sugahara, and Y. Kakinuma. 2009. Tributyltin induces Yca1p-dependent cell death of yeast Saccharomyces cerevisiae. J. Toxicol. Sci. 34: 541-545. DOI ScienceOn |
7 | Degen, G. H. and H. M. Bolt. 2000. Endocrine disruptors: Update on xenoestrogens. Int. Arch. Occup. Environ. Health 73: 433-441. DOI ScienceOn |
8 | Fent, K. 1996. Ecotoxicology of organotin compounds. Crit. Rev. Toxicol. 26: 1-117. |
9 | Feral, C. and S. Le Gall. 1983. The influence of a pollutant factor (TBT) on the neurosecretory mechanism responsible for the occurrence of a penis in the females of Ocenebra erinacea, pp.173-175. In J. Lever and H. H. Boer (eds.). Molluscan Neuro-Endocrinology. North Holland Publishing, Amsterdam. |
10 | Gibbs, F. E. and G. W. Bryan. 1986. Reproductive failure in populations of the dog-whelk, Nucella lapillus, caused by imposex induced by tributyltin from antifouling paints. J. Mar. Biol. Assoc. UK 66: 767-777. DOI |
11 | Horiguchi, T. 2006. Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex. Environ. Sci. 13: 77-87. |
12 | Horiguchi, T., H. Shiraishi, M. Shimizu, and M. Morita. 1997. Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell. Thais clavigera. Environ. Pollut. 95: 85-91. DOI ScienceOn |
13 | Iguchi, T., Y. Katsu, T. Horiguchi, H. Watanabe, B. Blumberg, and Y. Ohta. 2007. Endocrine disrupting organotin compounds are potent inducers of imposex in gastropods and adipogenesis in vertebrates. Mol. Cell Toxicol. 3: 1-10. |
14 | Kajiwara, M., S. Kuraku, T. Kurokawa, K. Kato, S. Toda, H. Hirose, et al. 2006. Tissue preferential expression of estrogen receptor gene in the marine snail, Thais clavigera. Gen. Comp. Endocr. 148: 315-326. DOI ScienceOn |
15 | Kanayama, T., N. Kobayashi, S. Mamiya, T. Nakanishi, and J. Nishikawa. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol. Pharmacol. 67: 766-774. |
16 | Kannan, K., S. Tanabe, H. Iwata, and R. Tatsukawa. 1995. Butyltins in muscle and liver of fish collected from certain asian and oceanian countries. Environ. Pollut. 90: 279-290. DOI ScienceOn |
17 | Kannan, K., S. Tanabe, and R. Tatsukawa. 1995. Occurrence of butyltin residues in certain foodstuffs. Bull. Environ. Contam. Toxicol. 55: 510-516. |
18 | Li, B. and S. Fields. 1993. Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. FASEB J. 7: 957-963. |
19 | Lee, H. S., E. M. Cho, J. H. Jung, and A. Ohta. 2007. Evaluation on antagonist activities of polycyclic aromatic hydrocarbons using the yeast two-hybrid detection system for endocrine disruptors. Environ. Monit. Assess. 129: 87-95. DOI |
20 |
Lee, H. S., K. Miyauchi, Y. Nagata, R. Fukuda, S. I. Sasagawa, H. Endoh, et al. 2002. Employment of the human estrogen receptor |
21 | Luker, G. D., V. Sharma, C. M. Pica, J. L. Prior, W. Li, and D. Piwnica-Worms. 2003. Molecular imaging of protein-protein interactions: Controlled expression of p53 and large T-antigen fusion proteins in Vivo. Cancer Res. 15: 1780-1788. |
22 | Madro, A., A. Korolczuk, G. Czechowska, K. Celi ski, M. S omka, B. Prozorow-Krol, and E. Korobowicz. 2008. RAS inhibitors decrease apoptosis of acinar cells and increase elimination of pancreatic stellate cells after in the course of experimental chronic pancreatitis induced by dibutyltin dichloride. J. Physiol. Pharmacol. 59: 239-249. |
23 | Mensink, B. P., H. Krault, A. Dick Vethaak, C. C. ten Hallers-Tjabbes, J. H. Koernan, B. A. van Hattun, and J. P. Boon. 2002. Imposex induction in laboratory reared juvenile Buccinum undatum by tributyltin (TBT). Environ. Toxicol. Pharmacol. 11: 49-65. DOI ScienceOn |
24 | Nakanishi, T. 2008. Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor. J. Toxicol. Sci. 33: 269-276. DOI ScienceOn |
25 | Saitoh, M., T. Yanase, H. Morinaga, M. Tanabe, Y. M. Mu, Y. Nishi, et al. 2001. Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN. Biochem. Biophys. Res. Commun. 289: 198-204. DOI ScienceOn |
26 | Nakanishi, T., J. Nishikawa, Y. Hiromori, H. Yokoyama, M. Koyanagi, S. Takasuga, et al. 2005. Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol. Endocrinol. 19: 2502-2516. DOI ScienceOn |
27 | Nishikawa, J., S. Mamiya, T. Kanayama, T. Nishikawa, F. Shiraishi, and T. Horiguchi. 2004. Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. Environ. Sci. Technol. 38: 6271-6276. DOI ScienceOn |
28 | Roins, M. J. J. and A. Z. Mason. 1996. The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: Effects of tributyltin. Mar. Environ. Res. 42: 161-166. DOI ScienceOn |
29 | Santos, M. M., L. F. Castro, M. N. Vieira, J. Micael, R. Morabito, P. Massanisso, and M. A. Reis-Henriques. 2005. New insights into the mechanism of imposex induction in the dogwhelk Nucella lapillus. Comp. Biochem. Phys. C Toxicol. Pharm. 141: 101-109. DOI ScienceOn |
30 | Snoeij, N. J., A. H. Penninks, and W. Seinen. 1987. Biological activity of organotin compounds: An overview. Environ. Res. 44: 335-353. DOI ScienceOn |
31 | Spooner, N., P. E. Gibbs, G. W. Bryan, and G. L. Goad. 1991. The effect of tributyltin upon steroid titers in the female dogwhelk, Nucella lapillus, and the development of imposex. Mar. Environ. Res. 32: 37-49. DOI ScienceOn |
32 | Stridh, H., S. Orrenius, and M. B. Hampton. 1999. Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin. Toxicol. Appl. Pharm. 156: 141-146. DOI ScienceOn |
33 | Yamabe, Y., A. Hoshino, N. Imura, T. Suzuki, and S. Himeno. 2000. Enhancement of androgen-dependent transcription and cell proliferation by tributyltin and triphenyltin. Toxicol. Appl. Pharmacol. 169: 177-184. DOI ScienceOn |
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