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http://dx.doi.org/10.4014/jmb.1108.08069

New Production of 5-Bromotoluhydroquinone and 4-O-Methyltoluhydroquinone from the Marine-Derived Fungus Dothideomycete sp.  

Leutou, Alain S. (Department of Chemistry, Pukyong National University)
Yun, Keum-Ja (Department of Chemistry, Pukyong National University)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Kang, Jung-Sook (School of Dentistry, Pusan National University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Journal of Microbiology and Biotechnology / v.22, no.1, 2012 , pp. 80-83 More about this Journal
Abstract
The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5-bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 ${\mu}g/ml$, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with $IC_{50}$ values of 11.0, 17.0, 12.0, and 7.0 ${\mu}M$, respectively, which were more active than the positive control, L-ascorbic acid ($IC_{50}$, 20.0 ${\mu}M$).
Keywords
5-Bromotoluhydroquinone; 4-O-methyltoluhydroquinone; toluhydroquinone; gentisyl alcohol; Dothideomycete sp;
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