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http://dx.doi.org/10.4014/jmb.1011.11002

Antiviral Activity of Methylelaiophylin, an ${\alpha}$-Glucosidase Inhibitor  

Lee, Do-Seung (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Woo, Jin-Kyu (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Kim, Dong-Hern (Bio-Crop Division, Department of Agricultural Biotechnology, National Academy of Agricultural Science, Rural Development Administration)
Kim, Min-Young (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Cho, So-Mi K. (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Kim, Jae-Hoon (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Park, Se-Pill (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Lee, Hyo-Yeon (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Riu, Key Zung (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Lee, Dong-Sun (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
Publication Information
Journal of Microbiology and Biotechnology / v.21, no.3, 2011 , pp. 263-266 More about this Journal
Abstract
Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an ${\alpha}$-glucosidase inhibitor with an $IC_{50}$ value of 10 ${\mu}M$. It showed mixed-type inhibition of ${\alpha}$-glucosidase with a $K_i$ value of 5.94 ${\mu}M$. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
Keywords
${\alpha}$-Glucosidase inhibitor; methylelaiophylin; trafficking inhibitor;
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