External and Internal Glucose Mass Transfers in Succinic Acid Fermentation with Stirred Bed of Immobilized Actinobacillus succinogenes under Substrate and Product Inhibitions
![]() |
Galaction, Anca-Irina
("Gr.T. Popa" University of Medicine and Pharmacy of Iasi, Department of Biotechnologies)
Rotaru, Roxana ("Gh. Asachi" Technical University of Iasi, Department of Biochemical Engineering) Kloetzer, Lenuta ("Gh. Asachi" Technical University of Iasi, Department of Biochemical Engineering) Vlysidis, Anestis (Satake Center for Grain Process Engineering, University of Manchester) Webb, Colin (Satake Center for Grain Process Engineering, University of Manchester) Turnea, Marius ("Gr.T. Popa" University of Medicine and Pharmacy of Iasi, Department of Biotechnologies) Cascaval, Dan ("Gh. Asachi" Technical University of Iasi, Department of Biochemical Engineering) |
1 | Arikawa, Y., T. Kuroyanagi, M. Shimosaka, H. Muratsubaki, K. Enomoto, R. Kodaira, and M. Okazaki. 1999. Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. J. Biosci. Bioeng. 87: 28-36. DOI ScienceOn |
2 | Bird, R. B., W. E. Stewart, and N. E. Lightfoot. 1960. Transport Phenomena. Wiley, New York. |
3 | Ca caval, D. and A. I. Galaction. 2007. The European colour of biotechnology is white. Rom. Biotechnol. Lett. 12: 3489-3494. |
4 | Chen, K., M. Jiang, P. Wei, J. Yao, and H. Wu. 2010. Succinic acid production from acid hydrolysate of corn fiber by Actinobacillus succinogenes. Appl. Biochem. Biotechnol. 160: 477-485. DOI ScienceOn |
5 | Corona-Gonzalez, R. I., A. Bories, V. Gonzalez-Alvarez, and C. Pelayo-Ortiz. 2008. Kinetic study of succinic acid production by Actinobacillus succinogenes ZT-130. Process Biochem. 43: 1047-1053. DOI ScienceOn |
6 | David, H., M. Akesson, and J. Nielsen. 2003. Reconstruction of the central carbon metabolism of Aspergillus niger. J. Dairy Sci. 270: 4243-4253. |
7 | Dorado, M. P., S. K. C. Lin, A. Koutinatis, C. Du, R. Wang, and C. Webb. 2009. Cereal-based biorefinery development: Utilisation of wheat milling by-products for the production of succinic acid. J. Biotechnol. 143: 51-59. DOI ScienceOn |
8 | Estape, D., F. Godia, and C. Sola. 1992. Determination of glucose and ethanol diffusion coefficients in Ca-alginate gel. Enzyme Microbiol. Technol. 14: 396-401. DOI ScienceOn |
9 | Galaction, A. I., A. M. Lup teanu, and D. Ca caval. 2007. Bioreactors with stirred bed of immobilized cells. 1. Studies on mixing efficiency. Environ. Eng. Manag. J. 6: 101-110. |
10 | Liu, Y. P., P. Zheng, Z. H. Sun, Y. Ni, J. J. Dong, and P. Wei. 2008. Strategies of pH control and glucose-fed batch fermentation for production of succinic acid by Actinobacillus succinogenes CGMCC1593. J. Chem. Technol. Biotechnol. 83: 722-729. DOI ScienceOn |
11 | Liu, Y. P., P. Zheng, Z. H. Sun, Y. Ni, J. J. Dong, and L. L. Zhu. 2008. Economical succinic acid production from cane molasses by Actinobacillus succinogenes. Bioresource Technol. 99: 1736-1742. DOI ScienceOn |
12 |
McIntyre, M. and B. McNeil. 1997. Effects of elevated dissolved |
13 | McKinlay, J. B., J. G. Zeikus, and C. Vieille. 2005. Insights into Actinobacillus succinogenes fermentative metabolism in a chemically defined growth medium. Appl. Environ. Microbiol. 71: 6651-6656. DOI ScienceOn |
14 | Moon, S. K., Y. J. Wee, J. S. Yun, and H. W. Ryu. 2004. Production of fumaric acid using rice brain and subsequent conversion to succinic acid through a two-step process. Appl. Biochem. Biotechnol. 113-116: 834-855. |
15 | Perry, R. H. and C. H. Chilton. 1973. Chemical Engineers Handbook. 5th Ed. McGraw-Hill, New York. |
16 | Song, H. and S. Y. Lee. 2006. Production of succinic acid by bacterial fermentation. Enz. Microb. Technol. 39: 352-361. DOI ScienceOn |
17 | Vicente, A. A., M. Dluhy, E. C. Ferreira, M. Mota, and J. A. Teixeira. 1998. Mass transfer properties of glucose and O2 in S. cerevisiae flocs. Biochem. Eng. J. 2: 35-43. DOI ScienceOn |
18 | Urbance, S. E., A. L. Pometto III, A. A. DiSpirito, and A. Demirci. 2003. Medium evaluation and plastic composite support ingredient selection for biofilm formation and succinic acid production by Actinobacillus succinogenes. Food Biotechnol. 17: 53-65. DOI ScienceOn |
19 | Urbance, S. E., A. L. Pometto III, A. A. DiSpirito, and Y. Denli. 2004. Evaluation of succinic acid continuous and repeatbatch biofilm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors. Appl. Biochem. Biotechnol. 65: 664-670. |
20 | Van Gylswyk, N. O. 1995. Succiniciclasticum ruminis gen-nov, sp.-nov, a ruminal bacterium converting succinate to propionate as the sole energy-yielding mechanism. Int. J. Syst. Bacteriol. 45: 297-300. DOI ScienceOn |
21 | Vlysidis, A., M. Binns, C. Webb, and C. Thoedoropoulos. 2009. Utilisation of glycerol to platform chemicals within the biorefinery concept: A case for succinate production. Chem. Eng. Trans. 18: 537-542. |
22 | Zeikus, J. G., M. K. Jain, and P. Elankovan. 1999. Biotechnology of succinic acid production and markets for derived industrial products. Appl. Microbiol. Biotechnol. 51: 345-352. |
23 | Williams, D. and D. M. Munnecke. 1981. The production of ethanol by immobilized yeast cells. Biotechnol. Bioeng. 23: 1813-1825. DOI |
24 | Willke, T. and K. D. Vorlop. 2004. Industrial bioconversion of renewable resources as an alternative to conventional chemistry. Appl. Microbiol. Biotechnol. 66: 131-142. DOI ScienceOn |
25 | Zaiat, M., J. A. D. Rodrigues, and E. Foresti. 2000. External and internal mass transfer effects in an anaerobic fixed-bed reactor for wastewater treatment. Process Biochem. 35: 943- 949. DOI ScienceOn |
26 | Li, Q., D. Wang, Y. Wu, M. Yang, W. Li, J. Xing, and Z. Su. 2010. Kinetic evaluation of products inhibition to succinic acid producers Escherichia coli NZN111, AFP111, BL21, and Actinobacillus succinogenes 130ZT. J. Microbiol. 48: 290-296. DOI |
27 | Galaction, A. I., A. M. Lup teanu, M. Turnea, and D. Ca caval. 2010. Effect on internal diffusion on bioethanol production in a bioreactor with yeasts cells immobilized on mobile beds. Environ. Eng. Manag. J. 9: 675-680. |
28 | Inui, M., S. Murakami, S. Okino, H. Kawaguchi, A. A. Verties, and H. Yukawa. 2004. Metabolic analysis of Corynebacterium glutamicum during lactate and succinate production under oxygen deprivation conditions. J. Mol. Microbiol. Biotechnol. 7: 182-196. DOI ScienceOn |
29 | Li, J., M. Jiang, K. Chen, L. Shang, P. Wei, H. Y. Q. Ye, et al. 2010. Enhanced production of succinic acid by Actinobacillus succinogenes with reductive carbon source. Process Biochem. 45: 980-985. DOI ScienceOn |
30 | Lin, S. K. C., C. Du, A. Koutinatis, R. Wang, and C. Webb. 2008. Substrate and product inhibition kinetics in succinic acid production by Actinobacillus succinogenes. Biochem. Eng. J. 41: 128-135. DOI ScienceOn |
31 | Ling, E. T. M., J. T. Dibble, M. R. Houston, L. B. Lockwood, and L. P. Elliott. 1978. Accumulation of 1-trans-2,3-epoxysuccinic acid and succinic acid by Paecilomyces varioti. Appl. Environ. Microbiol. 35: 1213-1215. |
![]() |