Enhanced Flavonoid Production in Streptomyces venezuelae via Metabolic Engineering |
Park, Sung-Ryeol
(Department of Chemistry and Nano Science, Ewha Womans University)
Ahn, Mi-Sun (Department of Chemistry and Nano Science, Ewha Womans University) Han, Ah-Reum (Department of Chemistry and Nano Science, Ewha Womans University) Park, Je-Won (Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University) Yoon, Yeo-Joon (Department of Chemistry and Nano Science, Ewha Womans University) |
1 | Hughes, A. J. and A. Keatinge-Clay. 2011. Enzymatic extender unit generation for in vitro polyketide synthase reactions: Structural and functional showcasing of Streptomyces coelicolor MatB. Chem. Biol. 18: 165-176. DOI ScienceOn |
2 | Jung, W. S., S. K. Lee, J. S. J. Hong, S. R. Park, S. J. Jeong, A. R. Han, et al. 2006. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl. Microbiol. Biotechnol. 72: 763- 769. DOI ScienceOn |
3 | Jung, W. S., S. J. Jeong, S. R. Park, C. Y. Choi, B. C. Park, J. W. Park, and Y. J. Yoon. 2008. Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae. Appl. Environ. Microbiol. 74: 1972-1979. DOI ScienceOn |
4 | Kieser, T. M., M. J. Bibb, M. J. Buttner, K. F. Chater, and D. A. Hoopwood. 2000. Practical Streptomyces Genetics. John Innes Foundation, Norwich, England. |
5 | Leonard, E., Y. Yan, Z. L. Fowler, Z. Li, C. G. Lim, K. H. Lim, and M. A. Koffas. 2008. Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids. Mol. Pharm. 5: 257-265. DOI ScienceOn |
6 | Lombo, F., B. Pfeifer, T. Leaf, S. Ou, Y. S. Kim, D. E. Cane, P. Licari, and C. Khosla. 2001. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. Biotechnol. Prog. 17: 612-617. DOI ScienceOn |
7 | Park, S. R., J. H. Paik, M. S. Ahn, J. W. Park, and Y. J. Yoon. 2010. Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae. J. Microbiol. Boitechnol. 20: 1295- 1299. DOI |
8 | Weisshaar, B. and G. I. Jenkins. 1998. Phenylpropanoid biosynthesis and its regulation. Curr. Opin. Plant Biol. 1: 251- 257. DOI ScienceOn |
9 | Park, S. R., J. A. Yoon, J. H. Paik, J. W. Park, W. S. Jung, Y. H. Ban, et al. 2009. Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae. J. Biotechnol. 141: 181-188. DOI ScienceOn |
10 | Quideau, S., D. Deffieux, C. Douat-Casassus, and L. Pouységu. 2011. Plant polyphenols: Chemical properties, biological activities, and synthesis. Angew. Chem. Int. Ed. Engl. 50: 586-621. DOI ScienceOn |
11 | Winkel-Shirley, B. 2001. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol. 126: 485-493. DOI ScienceOn |
12 | Yao, L. H., Y. M. Jiang, J. Shi, F. A. Tomas-Barberan, N. Datta, R. Singanusong, and S. S. Chen. 2004. Flavonoids in food and their health benefits. Plant Foods Hum. Nutr. 59: 113-122. DOI ScienceOn |