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http://dx.doi.org/10.4014/jmb.1004.04028

Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus  

Ryoo, In-Ja (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Yun, Bong-Sik (College of Environmental and Bioresource Sciences, Chunbuk National University)
Lee, In-Kyoung (College of Environmental and Bioresource Sciences, Chunbuk National University)
Kim, Young-Hee (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Lee, Ik-Soo (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ahn, Jong-Seok (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Yoo, Ick-Dong (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.20, no.8, 2010 , pp. 1189-1191 More about this Journal
Abstract
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with $IC_{50}$ values of 5.2 and 4.6 ${\mu}M$, respectively.
Keywords
Hibiscus syriacus; hydroxyhibiscone A; human neutrophil elastase;
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