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http://dx.doi.org/10.4014/jmb.1002.02012

Biotransformation of Bioactive (-)-Mellein by a Marine Isolate of Bacterium Stappia sp.  

Feng, Zhile (Department of Chemistry, Pukyong National University)
Nenkep, Viviane N. (Department of Chemistry, Pukyong National University)
Yun, Keum-Ja (Department of Chemistry, Pukyong National University)
Zhang, Dahai (Department of Chemistry, Pukyong National University)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Kang, Jung-Sook (College of Dentistry, Pusan National University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Journal of Microbiology and Biotechnology / v.20, no.6, 2010 , pp. 985-987 More about this Journal
Abstract
The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marinederived fungus Cladosporium sp., was studied. The preparativescale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
Keywords
Biotransformation; dihydroisocoumarin; (-)-mellein; (3R,4S)-4-hydroxymellein; Stappia sp.;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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