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http://dx.doi.org/10.4014/jmb.0911.11014

Resveratrol Impaired the Morphological Transition of Candida albicans Under Various Hyphae-Inducing Conditions  

Okamoto-Shibayama, Kazuko (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College)
Sato, Yutaka (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College)
Azuma, Toshifumi (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College)
Publication Information
Journal of Microbiology and Biotechnology / v.20, no.5, 2010 , pp. 942-945 More about this Journal
Abstract
The ability of the human fungal pathogen Candida albicans to undergo the morphological transition from a single yeast form to pseudohyphal and hyphal forms in response to various conditions is known to be important for its virulence. Many studies have shown the pharmacological effects of resveratrol, a phytoalexin polyphenolic compound. In this study, we investigated the antifungal activity of resveratrol against C. albicans. Both yeast-form and mycelial growth of C. albicans were inhibited by resveratrol. In addition, normal filamentation of C. albicans was affected and yeast-to-hypha transition under serum-, pH-, and nutrient-induced hyphal growth conditions was impaired by resveratrol.
Keywords
Candida albicans; resveratrol (trans-3,4',-5-trihydroxystilbene); dimorphism;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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1 Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.   DOI   ScienceOn
2 Sanchez-Martinez, C. and J. Perez-Martin. 2002. Site-specific targeting of exogenous DNA into the genome of Candida albicans using the FLP recombinase. Mol. Genet. Genomics 268: 418-424.   DOI   ScienceOn
3 Watamoto, T., L. P. Samaranayake, J. A. Jayatilake, H. Egusa, H. Yatani, and C. J. Seneviratne. 2009. Effect of filamentation and mode of growth on antifungal susceptibility of Candida albicans. Int. J. Antimicrob. Agents 34: 333-339.   DOI   ScienceOn
4 Weber, K., B. Schulz, and M. Ruhnke. 2009. Resveratrol and its antifungal activity against Candida species. Mycoses [In Press.]
5 Jung, H. J., Y. B. Seu, and D. G. Lee. 2007. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J. Microbiol. Biotechnol. 17: 1324-1329.   과학기술학회마을
6 Odds, F. C. 1987. Candida infections: An overview. Crit. Rev. Microbiol. 15: 1-5.   DOI
7 Kanafani, Z. A. and J. R. Perfect. 2008. Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact. Clin. Infect. Dis. 46: 120-128.   DOI   ScienceOn
8 Lee, S. K., H. J. Lee, H. Y. Min, E. J. Park, K. M. Lee, Y. H. Ahn, Y. J. Cho, and J. H. Pyee. 2005. Antibacterial and antifungal activity of pinosylvin, a constituent of pine. Fitoterapia 76: 258-260.   DOI   ScienceOn
9 Li, Y., C. Su, X. Mao, F. Cao, and J. Chen. 2007. Roles of Candida albicans Sfl1 in hyphal development. Eukaryot. Cell 6: 2112-2121.   DOI   ScienceOn
10 Ogasawara, A., N. Komaki, H. Akai, K. Hori, H. Watanabe, T. Watanabe, T. Mikami, and T. Matsumoto. 2007. Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. Bull. 30: 284-286.   DOI   ScienceOn
11 Sudbery, P., N. Gow, and J. Berman. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12: 317-324.   DOI   ScienceOn
12 Bhat, K. P. and J. M. Pezzuto. 2002. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci. 957: 210-229.   DOI   ScienceOn
13 Hawser, S. 1996. Comparisons of the susceptibilities of planktonic and adherent Candida albicans to antifungal agents: A modified XTT tetrazolium assay using synchronised C. albicans cells. J. Med. Vet. Mycol. 34: 149-152.   DOI   ScienceOn
14 de Repentigny, L., D. Lewandowski, and P. Jolicoeur. 2004. Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection. Clin. Microbiol. Rev. 17: 729-759.   DOI   ScienceOn
15 Docherty, J. J., M. M. Fu, and M. Tsai. 2001. Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis. J. Antimicrob. Chemother. 47: 243-244.   DOI   ScienceOn
16 Donnelly, L. E., R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. Leung, K. Ito, R. E. Russell, and P. J. Barnes. 2004. Antiinflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 287: L774-L783.   DOI   ScienceOn
17 Ignatowicz, E. and W. Baer-Dubowska. 2001. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. Pharmacol. 53: 557-569.
18 Jung, H. J., I. A. Hwang, W. S. Sung, H. Kang, B. S. Kang, Y. B. Seu, and D. G. Lee. 2005. Fungicidal effect of resveratrol on human infectious fungi. Arch. Pharm. Res. 28: 557-560.   과학기술학회마을   DOI   ScienceOn
19 Abe, S., T. Satoh, Y. Tokuda, S. Tansho, and H. Yamaguchi. 1994. A rapid colorimetric assay for determination of leukocytemediated inhibition of mycelial growth of Candida albicans. Microbiol. Immunol. 38: 385-388.   DOI
20 Abe, S., Y. Sato, S. Inoue, H. Ishibashi, N. Maruyama, T. Takizawa, H. Oshima, and H. Yamaguchi. 2003. Anti-Candida albicans activity of essential oils including lemongrass (Cymbopogon citratus) oil and its component, citral. Nippon Ishinkin Gakkai Zasshi 44: 285-291.   DOI   ScienceOn
21 Baur, J. A. and D. A. Sinclair. 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 5: 493-506.   DOI   ScienceOn