[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.0910.10019

The Synergistic Antibacterial Activity of 1-Acetyl- $\beta$ -Carboline and $\beta$ -Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)

Shin, Hee-Jae (Marine Natural Products Laboratory, Korea Ocean Research and Development Institute)
Lee, Hyi-Seung (Marine Natural Products Laboratory, Korea Ocean Research and Development Institute)
Lee, Dae-Sung (Department of Microbiology, Pukyong National University)

Publication Information

Journal of Microbiology and Biotechnology / v.20, no.3, 2010 , pp. 501-505 More about this Journal

Abstract

1-Acetyl- $\beta$ -carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Combination of 1-acetyl- $\beta$ -carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.

Keywords

Streptomyces sp. 04DH52; anti-MRSA agent; 1-acetyl- $\beta$ -carboline;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)
Times Cited By Web Of Science : 1 (Related Records In Web of Science)

Reference
Cited By KSCI

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KSCI

The Synergistic Antibacterial Activity of 1-Acetyl--Carboline and -Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)

The Synergistic Antibacterial Activity of 1-Acetyl- $\beta$ -Carboline and $\beta$ -Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)