[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.0908.08007

A Brief Overview of Escherichia coli O157:H7 and Its Plasmid O157

Lim, Ji-Youn (Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho)
Yoon, Jang-W. (Advanced Human Resource and Research Group for Medical Science (BK21), Konkuk University, School of Medicine)
Hovde, Carolyn J. (Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho)

Publication Information

Journal of Microbiology and Biotechnology / v.20, no.1, 2010 , pp. 5-14 More about this Journal

Abstract

Enterohemorrhagic Escherichia coli O157:H7 is a major foodborne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7, and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The abilities to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment require that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, products of the pathogenicity island called the locus of enterocyte effacement, and products of the F-like plasmid pO157. Among these virulence factors, the role of pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on pO157.

Keywords

E. coli O157:H7; pO157;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)
Times Cited By Web Of Science : 15 (Related Records In Web of Science)

Reference
Cited By KSCI

1	Grys, T. E., M. B. Siegel, W. W. Lathem, and R. A. Welch. 2005. The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells. Infect. Immun. 73: 1295-1303. DOI ScienceOn
2	Yoon, J. W. and C. J. Hovde. 2008. All blood, no stool: Enterohemorrhagic Escherichia coli O157:H7 infection. J. Vet. Sci. 9: 219-231. DOI ScienceOn
3	Kaniuk, N. A., E. Vinogradov, J. Li, M. A. Monteiro, and C. Whitfield. 2004. Chromosomal and plasmid-encoded enzymes are required for assembly of the R 3-type core oligosaccharide in the lipopolysaccharide of Escherichia coli O157:H7. J. Biol. Chem. 279: 31237-31250. DOI
4	Ostroff, S. M., P. I. Tarr, M. A. Neill, J. H. Lewis, N. Hargrett-Bean, and J. M. Kobayashi. 1989. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections. J. Infect. Dis. 160: 994-998. DOI ScienceOn
5	Castanie-Cornet, M. P., T. A. Penfound, D. Smith, J. F. Elliott, and J. W. Foster. 1999. Control of acid resistance in Escherichia coli. J. Bacteriol. 181: 3525-3535.
6	Delahay, R. M., G. Frankel, and S. Knutton. 2001. Intimate interactions of enteropathogenic Escherichia coli at the host cell surface. Curr. Opin. Infect. Dis. 14: 559-565. DOI ScienceOn
7	Cray, W. C. Jr. and H. W. Moon. 1995. Experimental infection of calves and adult cattle with Escherichia coli O157:H7. Appl. Environ. Microbiol. 61: 1586-1590.
8	Dunn, J. R., J. E. Keen, and R. A. Thompson. 2004. Prevalence of Shiga-toxigenic Escherichia coli O157:H7 in adult dairy cattle. J. Am. Vet. Med. Assoc. 224: 1151-1158. DOI
9	Barker, J., T. J. Humphrey, and M. W. Brown. 1999. Survival of Escherichia coli O157 in a soil protozoan: Implications for disease. FEMS Microbiol. Lett. 173: 291-295. DOI ScienceOn
10	Burland, V., Y. Shao, N. T. Perna, G. Plunkett, H. J. Sofia, and F. R. Blattner. 1998. The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7. Nucl. Acids Res. 26: 4196-4204. DOI
11	Cho, S., J. B. Bender, F. Diez-Gonzalez, C. P. Fossler, C. W. Hedberg, J. B. Kaneene, P. L. Ruegg, L. D. Warnick, and S. J. Wells. 2006. Prevalence and characterization of Escherichia coli O157 isolates from Minnesota dairy farms and county fairs. J. Food Prot. 69: 252-259.
12	Elliott, S. J., V. Sperandio, J. A. Giron, S. Shin, J. L. Mellies, L. Wainwright, S. W. Hutcheson, T. K. McDaniel, and J. B. Kaper. 2000. The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohemorrhagic Escherichia coli. Infect. Immun. 68: 6115-6126. DOI ScienceOn
13	Frenzen, P. D., A. Drake, and F. J. Angulo. 2005. Economic cost of illness due to Escherichia coli O157 infections in the United States. J. Food Prot. 68: 2623-2630.
14	Frost, L. S., R. Leplae, A. O. Summers, and A. Toussaint. 2005. Mobile genetic elements: The agents of open source evolution. Nat. Rev. Microbiol. 3: 722-732. DOI ScienceOn
15	Kim, S. H., W. Jia, R. E. Bishop, and C. Gyles. 2004. An msbB homologue carried in plasmid pO157 encodes an acyltransferase involved in lipid A biosynthesis in Escherichia coli O157:H7. Infect. Immun. 72: 1174-1180. DOI ScienceOn
16	Griffin, P. M. and R. V. Tauxe. 1991. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome. Epidemiol. Rev. 13: 60-98.
17	Hancock, D. D., T. E. Besser, D. H. Rice, D. E. Herriott, and P. I. Tarr. 1997. A longitudinal study of Escherichia coli O157 in fourteen cattle herds. Epidemiol. Infect. 118: 193-195. DOI ScienceOn
18	Jiang, X., J. Morgan, and M. P. Doyle. 2002. Fate of Escherichia coli O157:H7 in manure-amended soil. Appl. Environ. Microbiol. 68: 2605-2609. DOI ScienceOn
19	Klapproth, J. M. A., I. C. A. Scaletsky, B. P. McNamara, L. C. Lai, C. Malstrom, S. P. James, and M. S. Donnenberg. 2000. A large toxin from pathogenic Escherichia coli strains that inhibits lymphocyte activation. Infect. Immun. 68: 2148-2155. DOI ScienceOn
20	Makino, K., K. Ishii, T. Yasunaga, M. Hattori, K. Yokoyama, C. H. Yutsudo, et al. 1998. Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res. 5: 1-9. DOI ScienceOn
21	Mead, P. S., L. Slutsker, V. Dietz, L. F. McCaig, J. S. Bresee, C. Shapiro, P. M. Griffin, and R. V. Tauxe. 1999 Food-related illness and death in the United States. Emerg. Infect. Dis. 5: 607-625. DOI
22	Melton-Celsa, A. R., S. C. Darnell, and A. D. O'Brien. 1996. Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice. Infect. Immun. 64: 1569-1576.
23	Michino, H., K. Araki, S. Minami, S. Takaya, N. Sakai, M. Miyazaki, A. Ono, and H. Yanagawa. 1999. Massive outbreak of Escherichia coli O157:H7 infection in school children in Sakai City, Japan, associated with consumption of white radish sprouts. Am. J. Epidemiol. 150: 787-796. DOI ScienceOn
24	Perna, N. T., G. F. Mayhew, G. Posfai, S. Elliott, M. S. Donnenberg, J. B. Kaper, and F. R. Blattner. 1998. Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 66: 3810-3817.
25	Varma, J. K., K. D. Greene, M. E. Reller, S. M. DeLong, J. Trottier, S. F. Nowicki, et al. 2003. An outbreak of Escherichia coli O157 infection following exposure to a contaminated building. J.A.M.A. 290: 2709-2712. DOI ScienceOn
26	Perna, N. T., G. Plunkett, V. Burland, B. Mau, J. D. Glasner, D. J. Rose, et al. 2001. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 409: 529-533. DOI ScienceOn
27	Schmidt, H., B. Henkel, and H. Karch. 1997. A gene cluster closely related to type II secretion pathway operons of Gram-negative bacteria is located on the large plasmid of enterohemorrhagic Escherichia coli O157 strains. FEMS Microbiol. Lett. 148: 265-272. DOI ScienceOn
28	Tatsuno, I., M. Horie, H. Abe, T. Miki, K. Makino, H. Shinagawa, H. Taguchi, S. Kamiya, and T. Hayashi. 2001. toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype. Infect. Immun. 69: 6660-6669. DOI ScienceOn
29	Wells, J. G., B. R. Davis, I. K. Wachsmuth, L. W. Riley, R. S. Remis, R. Sokolow, and G. K. Morris. 1983. Laboratory investigation of hemorrhagic colitis outbreaks associated with a rare Escherichia coli serotype. J. Clin. Microbiol. 18: 512-520.
30	Yoon, J. W., S. A. Minnich, J. S. Ahn, Y. H. Park, A. Paszczynski, and C. J. Hovde. 2004. Thermoregulation of the Escherichia coli O157:H7 pO157 ecf operon and lipid A myristoyl transferase activity involves intrinsically curved DNA. Mol. Microbiol. 51: 419-435. DOI ScienceOn
31	Lathem, W. W., T. E. Grys, S. E. Witowski, A. G. Torres, J. B. Kaper, P. I. Tarr, and R. A. Welch. 2002. StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor. Mol. Microbiol. 45: 277-288. DOI ScienceOn
32	Gansheroff, L. J. and A. D. O'Brien. 2000. Escherichia coli O157:H7 in beef cattle presented for slaughter in the US: Higher prevalence rates than previously estimated. 97: 2959-2961. DOI ScienceOn
33	Shima, K., N. Yoshii, M. Akiba, K. Nishimura, M. Nakazawa, and S. Yamasaki. 2006. Comparison of PCR-RFLP and PFGE for determining the clonality of enterohemorrhagic Escherichia coli strains. FEMS Microbiol. Lett. 257: 124-131. DOI ScienceOn
34	Bauer, M. E. and R. A. Welch. 1996. Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 64: 167-175.
35	Deng, W., J. L. Puente, S. Gruenheid, Y. Li, B. A. Vallance, A. Vazquez, et al. 2004. Dissecting virulence: Systematic and functional analyses of a pathogenicity island. Proc. Natl. Acad. Sci. U.S.A. 101: 3597-3602. DOI ScienceOn
36	Dziva, F., A. Mahajan, P. Cameron, C. Currie, I. J. McKendrick, T. S. Wallis, D. G. E. Smith, and M. P. Stevens. 2007. EspP, a type V-secreted serine protease of enterohaemorrhagic Escherichia coli O157:H7, influences intestinal colonization of calves and adherence to bovine primary intestinal epithelial cells. FEMS Microbiol. Lett. 271: 258-264. DOI ScienceOn
37	Yoon, J. W., J. Y. Lim, Y. H. Park, and C. J. Hovde. 2005. Involvement of the Escherichia coli O157:H7(pO157) ecf operon and lipid A myristoyl transferase activity in bacterial survival in the bovine gastrointestinal tract and bacterial persistence in farm water troughs. Infect. Immun. 73: 2367-2378. DOI ScienceOn
38	Boerlin, P., S. A. McEwen, F. Boerlin-Petzold, J. B. Wilson, R. P. Johnson, and C. L. Gyles. 1999. Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans. J. Clin. Microbiol. 37: 497-503.
39	Brashears, M. M., M. L. Galyean, G. H. Loneragan, J. E. Mann, and K. Killinger-Mann. 2003. Prevalence of Escherichia coli O157:H7 and performance by beef feedlot cattle given Lactobacillus direct-fed microbials. J. Food Prot. 66: 748-754.
40	Yuk, H. G. and D. L. Marshall. 2004. Adaptation of Escherichia coli O157:H7 to pH alters membrane lipid composition, verotoxin secretion, and resistance to simulated gastric fluid acid. Appl. Environ. Microbiol. 70: 3500-3505. DOI ScienceOn
41	LeJeune, J. T., T. E. Besser, and D. D. Hancock. 2001. Cattle water troughs as reservoirs of Escherichia coli O157. Appl. Environ. Microbiol. 67: 3053-3057. DOI ScienceOn
42	Lim, J. Y., H. Sheng, K. S. Seo, Y. H. Park, and C. J. Hovde. 2007. Characterization of an Escherichia coli O157:H7 Plasmid O157 deletion mutant and its survival and persistence in cattle. Appl. Environ. Microbiol. 73: 2037-2047. DOI ScienceOn
43	Naylor, S. W., J. C. Low, T. E. Besser, A. Mahajan, G. J. Gunn, M. C. Pearce, I. J. McKendrick, D. G. E. Smith, and D. L. Gally. 2003. Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host. Infect. Immun. 71: 1505-1512. DOI ScienceOn
44	Riley, L. W., R. S. Remis, S. D. Helgerson, H. B. McGee, J. G. Wells, B. R. Davis, et al. 1983. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N. Engl. J. Med. 308: 681-685. DOI ScienceOn
45	Morabito, S., R. Tozzoli, E. Oswald, and A. Caprioli. 2003. A mosaic pathogenicity island made up of the locus of enterocyte effacement and a pathogenicity island of Escherichia coli O157:H7 is frequently present in attaching and effacing E. coli. Infect. Immun. 71: 3343-3348. DOI ScienceOn
46	Orndorff, P. E., Y. Wang, S. H. Huang, C. A. Wass, M. F. Stins, and K. S. Kim. 1999. The gene locus yijP contributes to Escherichia coli K1 invasion of brain microvascular endothelial cells. Infect. Immun. 67: 4751-4756.
47	Sanderson, M. W., T. E. Besser, J. M. Gay, C. C. Gay, and D. D. Hancock. 1999. Fecal Escherichia coli O157:H7 shedding patterns of orally inoculated calves. Vet. Microbiol. 69: 199-205. DOI ScienceOn
48	Willshaw, G. A., H. R. Smith, T. Cheasty, P. G. Wall, and B. Rowe. 1997. Vero cytotoxin-producing Escherichia coli O157 outbreaks in England and Wales, 1995: Phenotypic methods and genotypic subtyping. Emerg. Infect. Dis. 3: 561-565. DOI
49	Banatvala, N., P. M. Griffin, K. D. Greene, T. J. Barrett, W. F. Bibb, J. H. Green, and J. G. Wells. 2001. The United States National Prospective Hemolytic Uremic Syndrome Study: Microbiologic, serologic, clinical, and epidemiologic findings. J. Infect. Dis. 183: 1063-1070. DOI ScienceOn
50	Brunder, W., H. Schmidt, and H. Karch. 1997. EspP, a novel extracellular serine protease of enterohaemorrhagic Escherichia coli O157:H7 cleaves human coagulation factor V. Mol. Microbiol. 24: 767-778. DOI ScienceOn
51	Peterson, W. L., P. A. Mackowiak, C. C. Barnett, M. Marling-Cason, and M. L. Haley. 1989. The human gastric bactericidal barrier: Mechanisms of action, relative antibacterial activity, and dietary influences. J. Infect. Dis. 159: 979-983. DOI ScienceOn
52	Heuvelink, A. E., C. van Heerwaarden, J. T. Zwartkruis-Nahuis, R. van Oosterom, K. Edink, Y. T. van Duynhoven, and E. de Boer. 2002. Escherichia coli O157 infection associated with a petting zoo. Epidemiol. Infect. 129: 295-302.
53	Lim, J. Y., J. Li, H. Sheng, T. E. Besser, K. Potter, and C. J. Hovde. 2007. Escherichia coli O157:H7 colonization at the rectoanal junction of long-duration culture-positive cattle. Appl. Environ. Microbiol. 73: 1380-1382. DOI ScienceOn
54	Putonti, C., Y. Luo, C. Katili, S. Chumakov, G. E. Fox, D. Graur, and Y. Fofanov. 2006. A computational tool for the genomic identification of regions of unusual compositional properties and its utilization in the detection of horizontally transferred sequences. Mol. Biol. Evol. 23: 1863-1868. DOI ScienceOn
55	Barrett, T. J., H. Lior, J. H. Green, R. Khakhria, J. G. Wells, B. P. Bell, K. D. Greene, J. Lewis, and P. M. Griffin. 1994. Laboratory investigation of a multistate food-borne outbreak of Escherichia coli O157:H7 by using pulsed-field gel electrophoresis and phage typing. J. Clin. Microbiol. 32: 3013-3017.
56	Dobrindt, U., F. Agerer, K. Michaelis, A. Janka, C. Buchrieser, M. Samuelson, et al. 2003. Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays. J. Bacteriol. 185: 1831-1840. DOI ScienceOn
57	Schlech III, W. F., D. P. Chase, and A. Badley. 1993. A model of food-borne Listeria monocytogenes infection in the Sprague-Dawley rat using gastric inoculation: Development and effect of gastric acidity on infective dose. Int. J. Food Microbiol. 18: 15-24. DOI ScienceOn
58	Saxena, S. K., A. D. O'Brien, and E. J. Ackerman. 1989. Shiga toxin, Shiga-like toxin II variant, and ricin are all single-site RNA N-glycosidases of 28S RNA when microinjected into Xenopus oocytes. J. Biol. Chem. 264: 596-601.
59	Maule, A. 2000. Survival of verocytotoxigenic Escherichia coli O157 in soil, water and on surfaces. Symp. Ser. Soc. Appl. Microbiol. 29: 71S-78S.
60	Nataro, J. P. and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11: 142-201.
61	Rangel, J. M., P. H. Sparling, C. Crowe, P. M. Griffin, and D. L. Swerdlow. 2005. Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002. Emerg. Infect. Dis. 11: 603-609. DOI
62	Hales, B. A., C. A. Hart, R. M. Batt, and J. R. Saunders. 1992. The large plasmids found in enterohemorrhagic and enteropathogenic Escherichia coli constitute a related series of transfer-defective Inc F-IIA replicons. Plasmid 28: 183-193. DOI ScienceOn
63	Schmidt, H., H. Karch, and L. Beutin. 1994. The large-sized plasmids of enterohemorrhagic Escherichia coli O157 strains encode hemolysins which are presumably members of the E. coli alpha-hemolysin family. FEMS Microbiol. Lett. 117: 189-196.
64	Sheng, H., J. Y. Lim, H. J. Knecht, J. Li, and C. J. Hovde. 2006. Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa. Infect. Immun. 74: 4685-4693. DOI ScienceOn
65	Thompson, J. S., D. S. Hodge, and A. A. Borczyk. 1990. Rapid biochemical test to identify verocytotoxin-positive strains of Escherichia coli serotype O157. J. Clin. Microbiol. 28: 2165-2168.
66	Kaper, J. B., J. P. Nataro, and H. L. Mobley. 2004. Pathogenic Escherichia coli. Nat. Rev. Microbiol. 2: 123-140. DOI ScienceOn
67	Benjamin, M. M. and A. R. Datta. 1995. Acid tolerance of enterohemorrhagic Escherichia coli. Appl. Environ. Microbiol. 61: 1669-1672.
68	Caprioli, A., S. Morabito, H. Brugere, and E. Oswald. 2005. Enterohaemorrhagic Escherichia coli: Emerging issues on virulence and modes of transmission. Vet. Res. 36: 289-311. DOI ScienceOn
69	Karmali, M. A., B. T. Steele, M. Petric, and C. Lim. 1983. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1: 619-620.
70	Paton, A. W. and J. C. Paton. 1999. Direct detection of Shiga toxigenic Escherichia coli strains belonging to serogroups O111, O157, and O113 by multiplex PCR. J. Clin. Microbiol. 37: 3362-3365.
71	van Diemen, P. M., F. Dziva, M. P. Stevens, and T. S. Wallis. 2005. Identification of enterohemorrhagic Escherichia coli O26:H-genes required for intestinal colonization in calves. Infect. Immun. 73: 1735-1743. DOI ScienceOn
72	Brunder, W., H. Schmidt, and H. Karch. 1996. KatP, a novel catalase-peroxidase encoded by the large plasmid of enterohaemorrhagic Escherichia coli 0157:H7. Microbiology 142: 3305-3315. DOI ScienceOn
73	Jacewicz, M. S., D. W. Acheson, D. G. Binion, G. A. West, L. L. Lincicome, C. Fiocchi, and G. T. Keusch. 1999. Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. Infect. Immun. 67: 1439-1444.
74	Stevens, M. P., A. J. Roe, I. Vlisidou, P. M. Van Diemen, R. M. La Ragione, A. Best, M. J. Woodward, D. L. Gally, and T. S. Wallis. 2004. Mutation of toxB and a truncated version of the efa-1 gene in Escherichia coli O157:H7 influences the expression and secretion of locus of enterocyte effacement-encoded proteins but not intestinal colonization in calves or sheep. Infect. Immun. 72: 5402-5411. DOI ScienceOn
75	Johnson, R. P., J. B. Wilson, P. Michel, K. Rahn, S. A. Renwick, C. L. Gyles, and J. S. Spika. 1999. Human infection with verotoxigenic Escherichia coli associated with exposure to farms and rural environments, pp. 147-168. In C. S. Stewart and H. J. Flints (eds.). Escherichia coli O157 in Farm Animals. CABI Publishing, Wallingford, U.K.
76	Schmidt, H., L. Beutin, and H. Karch. 1995. Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933. Infect. Immun. 63: 1055-1061.
77	Wick, L. M., W. Qi, D. W. Lacher, and T. S. Whittam. 2005. Evolution of genomic content in the stepwise emergence of Escherichia coli O157:H7. J. Bacteriol. 187: 1783-1791. DOI ScienceOn

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45	(2016) Journal of agricultural and food chemistry Fructosazine, a Polyhydroxyalkylpyrazine with Antimicrobial Activity: Mechanism of Inhibition against Extremely Heat Resistant <I>Escherichia coli</I> / 64 (45) , 8530
None	(2010) Gut pathogens Whole-genome sequencing and comparative genomic analysis of <I>Escherichia coli</I> O91 strains isolated from symptomatic and asymptomatic human carriers / 8 (None) , 57
6	(2010) Journal of food quality Growth and Volatile Compounds of <I>Escherichia coli</I> O157:H7 on Irradiated Pork / 39 (6) , 766
12	(2010) Current microbiology Strategies for Biofilm Inhibition and Virulence Attenuation of Foodborne Pathogen-Escherichia coli O157:H7 / 74 (12) , 1477
1	Gitishree Das. (2010) Foodborne pathogens and disease Antibacterial Properties of Endophytic Bacteria Isolated from a Fern Species Equisetum arvense L. Against Foodborne Pathogenic Bacteria Staphylococcus aureus and Escherichia coli O157:H7 / 14 (1) , 50
13	(2017) Journal of the Electrochemical Society : JES Review—New Twists in the Plot: Recent Advances in Electrochemical Genosensors for Disease Screening / 164 (13) , B665
1	(2010) Genes The Complex Relationship between Virulence and Antibiotic Resistance / 8 (1) , 39
2	(2017) Expert review of anti-infective therapy Delivering phage therapy <I>per os</I>: benefits and barriers / 15 (2) , 167
3	(2010) PLoS ONE <I>In-silico</I> design, expression, and purification of novel chimeric <I>Escherichia coli</I> O157:H7 OmpA fused to LTB protein in <I>Escherichia coli</I> / 12 (3) , e0173761
3	(2010) International journal of environmental research and public health Abundance of Pathogenic <I>Escherichia coli</I> Virulence-Associated Genes in Well and Borehole Water Used for Domestic Purposes in a Peri-Urban Community of South Africa / 14 (3) , 320
2	(2010) African journal of traditional, complementary, and alternative medicines <I>IN VITRO</I> STUDY OF CONCENTRATION-EFFECT AND TIME-COURSE PATTERN OF WHITE ALUM ON <I>ESCHERICHIA COLI</I> O157:H7 GROWTH / 14 (2) , 311
9	(2010) PLoS ONE Discovery of numerous novel small genes in the intergenic regions of the <I>Escherichia coli</I> O157:H7 Sakai genome / 12 (9) , e0184119
None	(2010) Gut pathogens Comparative genomic analysis and characteristics of NCCP15740, the major type of enterotoxigenic <I>Escherichia coli</I> in Korea / 9 (None) , 55
9	(2017) Molecules Chemical Composition, Antibacterial Activity, and Synergistic Effects with Conventional Antibiotics and Nitric Oxide Production Inhibitory Activity of Essential Oil from Geophila repens (L.) I.M. Jo / 22 (9) , 1561
None	(2010) Gut pathogens Comparative genomic analysis of Shiga toxin-producing and non-Shiga toxin-producing <I>Escherichia coli</I> O157 isolated from outbreaks in Korea / 9 (None) , 7
12	(2010) Emerging infectious diseases Evolutionary Context of Non–Sorbitol-Fermenting Shiga Toxin–Producing <I>Escherichia coli</I> O55:H7 / 23 (12) , 1966
4	(2017) Veterinary sciences Genomic Analysis of Third Generation Cephalosporin Resistant <I>Escherichia coli</I> from Dairy Cow Manure / 4 (4) , 57
11	(2010) Environmental monitoring and assessment Bacterial contamination and health risks of drinking water from the municipal non-government managed water treatment plants / 190 (11) , 685
5	(2010) Foodborne pathogens and disease Antibacterial Activities of Endophytic Bacteria Isolated from <I>Taxus brevifolia</I> Against Foodborne Pathogenic Bacteria / 15 (5) , 269
7	(2010) Future microbiology Global transcriptional regulation by BirA in enterohemorrhagic <I>Escherichia coli</I> O157:H7 / 13 (7) , 757
None	(2010) Frontiers in microbiology Differential Proteomic Analysis of Lactic Acid Bacteria— <I>Escherichia coli</I> O157:H7 Interaction and Its Contribution to Bioprotection Strategies in Meat / 9 (None) , 1083
None	(2010) Frontiers in microbiology Food-Associated Stress Primes Foodborne Pathogens for the Gastrointestinal Phase of Infection / 9 (None) , 1962
None	(2010) Frontiers in microbiology Pch Genes Control Biofilm and Cell Adhesion in a Clinical Serotype O157:H7 Isolate / 9 (None) , 2829
1	(2010) Slas technology A Combined Aqueous Two-Phase System and Spot-Test Platform for the Rapid Detection of <I>Escherichia coli</I> O157:H7 in Milk / 23 (1) , 57
2	(2010) Sensors Surface Plasmon Resonance and Bending Loss-Based U-Shaped Plastic Optical Fiber Biosensors / 18 (2) , 648
3	(2010) Cell death & disease A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic <I>Escherichia coli</I> / 9 (3) , 381
1	(2010) Advanced pharmaceutical bulletin Bacteriophage Isolated from Sewage Eliminates and Prevents the Establishment of <I>Escherichia Coli</I> Biofilm / 8 (1) , 85
5	(2010) PLoS ONE Sulfamethoxazole – Trimethoprim represses <I>csgD </I> but maintains virulence genes at 30°C in a clinical <I>Escherichia coli </I> O157:H7 isolate / 13 (5) , e0196271
8	(2010) PLoS ONE Whole genome shotgun sequencing revealed highly polymorphic genome regions and genes in <I>Escherichia coli</I> O157:H7 isolates collected from a single feedlot / 13 (8) , e0202775
10	(2010) Nutrients Probiotics in Autoimmune and Inflammatory Disorders / 10 (10) , 1537
44	(2010) The Journal of biological chemistry Plasma membrane profiling during enterohemorrhagic <I>E. coli</I> infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces / 293 (44) , 17188
22	(2010) Applied and environmental microbiology Stress Resistance Development and Genome-Wide Transcriptional Response of <I>Escherichia coli</I> O157:H7 Adapted to Sublethal Thymol, Carvacrol, and <I>trans</I>-Cinnamaldehyde / 84 (22) , e01616-18
None	(2010) Scientific reports Genetic diversity of the enterohaemolysin gene ( <I>ehxA</I> ) in non-O157 Shiga toxin-producing <I>Escherichia coli</I> strains in China / 8 (None) , 4233
None	(2010) Scientific reports Probiotic <I>Escherichia coli</I> inhibits biofilm formation of pathogenic <I>E. coli</I> via extracellular activity of DegP / 8 (None) , 4939
None	(2018) Scientific reports The influence of surface chemistry on the kinetics and thermodynamics of bacterial adhesion / 8 (None) , 17247
None	(2010) BMC evolutionary biology A novel short L-arginine responsive protein-coding gene ( laoB ) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting / 18 (None) , 21
None	(2010) Scientific reports Structure and tailspike glycosidase machinery of ORF212 from <I>E. coli</I> O157:H7 phage CBA120 (TSP3) / 9 (None) , 7349
None	(2010) Scientific reports Rapid, multiplexed, whole genome and plasmid sequencing of foodborne pathogens using long-read nanopore technology / 9 (None) , 16350
1	(2010) Virulence Identification and prevalence of <I>in vivo</I> -induced genes in enterohaemorrhagic <I>Escherichia coli</I> / 10 (1) , 180
2	(2010) Journal of pure & applied microbiology : an international research journal of microbiology Correlation of Antibiotic Resistance and Restriction Mapping of Plasmid DNA Isolated from E. coli Causing Urinary Tract Infection / 13 (2) , 949
None	(2010) Frontiers in microbiology Multistate Outbreaks of Foodborne Illness in the United States Associated With Fresh Produce From 2010 to 2017 / 10 (None) , 2667
None	(2019) Frontiers in microbiology GLAPD: Whole Genome Based LAMP Primer Design for a Set of Target Genomes / 10 (None) , 2860
2	(2010) International journal of organic chemistry Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria / 9 (2) , 85
14	(2010) Applied and environmental microbiology Effects of Sublethal Thymol, Carvacrol, and <I>trans</I>-Cinnamaldehyde Adaptation on Virulence Properties of <I>Escherichia coli</I> O157:H7 / 85 (14) , e00271-19
32	(2019) Microbiology resource announcements Complete Genome Sequence of Enterotoxigenic <I>Escherichia coli</I> Podophage LL11 / 8 (32) , e00693-19
6	(2010) Luminescence Binding interaction study on human serum albumin with bactericidal gold nanoparticles synthesized from a leaf extract of <I>Musa balbisiana</I>: a multispectroscopic approach / 34 (6) , 563
10	(2010) Foodborne pathogens and disease Control of Foodborne Pathogenic Bacteria by Endophytic Bacteria Isolated from <I>Ginkgo biloba</I> L. / 16 (10) , 661
18	(2010) Nucleic acids research High-throughput amplicon sequencing of the full-length 16S rRNA gene with single-nucleotide resolution / 47 (18) , e103
5	(2010) Physical review. E Packing of semiflexible polymers into viral capsid in crowded environments / 100 (5) , 052412
34	(2019) Current pharmaceutical design Preparation and Characterization of Agar Based Magnetic Nanocomposite for Potential Biomedical Applications / 25 (34) , 3672
20	(2010) Critical reviews in food science and nutrition Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges / 59 (20) , 3320
22	(2019) International journal of environmental research and public health Preharvest Transmission Routes of Fresh Produce Associated Bacterial Pathogens with Outbreak Potentials: A Review / 16 (22) , 4407
None	(2010) BMC microbiology High prevalence of non-O157 Shiga toxin-producing Escherichia coli in beef cattle detected by combining four selective agars / 19 (None) , 213
None	(2010) Gut pathogens RstA, a two-component response regulator, plays important roles in multiple virulence-associated processes in enterohemorrhagic Escherichia coli O157:H7 / 11 (None) , 53
None	(2019) Chemical and biological technologies in agriculture Application of MALDI-TOF mass spectrometry and specific PCR for tracking of E. coli O157:H− strain 431/97 in Batavia lettuce / 6 (None) , 2
None	(2010) Frontiers in bioengineering and biotechnology Novel Biogenic Silver Nanoparticle-Induced Reactive Oxygen Species Inhibit the Biofilm Formation and Virulence Activities of Methicillin-Resistant <I>Staphylococcus aureus</I> (MRSA) Strain / 8 (None) , 433
None	(2010) Frontiers in chemistry Aptamer-Based Biosensors for Environmental Monitoring / 8 (None) , 434
None	(2020) Frontiers in microbiology A Novel pH-Regulated, Unusual 603 bp Overlapping Protein Coding Gene <I>pop</I> Is Encoded Antisense to <I>ompA</I> in <I>Escherichia coli</I> O157:H7 (EHEC) / 11 (None) , 377
None	(2010) Frontiers in microbiology Pathogenomes of Atypical Non-shigatoxigenic <I>Escherichia coli</I> NSF/SF O157:H7/NM: Comprehensive Phylogenomic Analysis Using Closed Genomes / 11 (None) , 619
None	(2010) International dairy journal Production of functional mimics of human milk oligosaccharides by enzymatic glycosylation of bovine milk oligosaccharides / 102 (None) , 104583
4	(2010) Toxins Impact of Bacterial Toxins in the Lungs / 12 (4) , 223
None	(2010) Frontiers for young minds Bacteria in Soil Keep Your Hamburger “Healthy” / 8 (None) , 545905
6	(2020) Journal of applied physiology Physiological and microvascular responses to hemoglobin concentration-targeted hemolytic anemia in rats / 128 (6) , 1579
9	(2020) Current microbiology Novel Biosynthesis of Copper Nanoparticles Using Zingiber and Allium sp. with Synergic Effect of Doxycycline for Anticancer and Bactericidal Activity / 77 (9) , 2287
None	(2010) Water research A hidden risk: Survival and resuscitation of <I>Escherichia coli</I> O157:H7 in the viable but nonculturable state after boiling or microwaving / 183 (None) , 116102
20	(2020) Electrophoresis Rapid and highly sensitive detection of <I>Escherichia coli</I> O157:H7 in food with loop‐mediated isothermal amplification coupled to a new bioluminescent assay / 41 (20) , 1793
1	(2020) Bulletin of materials science Electroanalytical characteristic of a novel biosensor designed with graphene-polymer-based quaternary and mesoporous nanomaterials / 43 (1) , 121
12	(2010) Micro & nano letters Enhanced bactericidal activity of azithromycin‐coated silver nanoprisms in comparison to their spherical‐shaped counterparts / 15 (12) , 834
40	(2010) Journal of applied polymer science Fabrication of polycaprolactone nanofibrous membrane‐embedded microfluidic device for water filtration / 137 (40) , 49207
11	(2010) Microorganisms Association of Ct Values from Real-Time PCR with Culture in Microbiological Clearance Samples for Shiga Toxin-Producing <I>Escherichia coli</I> (STEC) / 8 (11) , 1801
12	(2010) Journal of food science : an official publication of the Institute of Food Technologists Inactivation of Shiga toxin‐producing <I>Escherichia coli</I> O157: H7 and mesophilic background microbiota of meat homogenate using elevated hydrostatic pressure, mild heat, and thymol / 85 (12) , 4335
1	(2021) Gut microbes Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7 / 13 (1) , 1992237
1	(2021) Foodborne pathogens and disease Occurrence, Molecular Characteristics, and Antimicrobial Resistance of <I>Escherichia coli</I> O157 in Cattle, Beef, and Humans in Bishoftu Town, Central Ethiopia / 18 (1) , 1
None	(2010) PeerJ Response of <I>Escherichia coli</I> minimal <I>ter</I> operon to UVC and auto-aggregation: pilot study / 9 (None) , e11197
None	(2010) Frontiers in microbiology Added Value of Genomic Surveillance of Virulence Factors in Shiga Toxin-Producing Escherichia coli in New South Wales, Australia / 12 (None) , 713724
None	(2021) Frontiers in microbiology The Fate of Foodborne Pathogens in Manure Treated Soil / 12 (None) , 781357
2	(2010) Journal of biomedical materials research. Part A Biological applications study of bio‐nanocomposites based on chitosan/ <SMALL> TIO 2</SMALL> nanoparticles polymeric films modified by oleic acid / 109 (2) , 232
None	(2010) Materials today communications A label-free electrochemical biosensor based on screen-printed electrodes modified with gold nanoparticles for quick detection of bacterial pathogens / 26 (None) , 101726
3	(2010) Processes Modelling and Optimization of Processing Factors of Pumpkin Seeds Oil Extraction under Uniaxial Loading / 9 (3) , 540
3	(2010) Chinese journal of analytical chemistry Rapid Visualized Detection of Escherichia Coli O157:H7 by DNA Hydrogel Based on Rolling Circle Amplification / 49 (3) , 377
None	(2010) LWT- Food science and technology Application of sage herbal dust essential oils and supercritical fluid extract for the growth control of <I>Escherichia coli</I> in minced pork during storage / 141 (None) , 110935
3	(2010) Jds communications Lactoferrin as an antimicrobial against Salmonella enterica and Escherichia coli O157:H7 in raw milk / 2 (3) , 92
5	(2021) Antibiotics Insights into Emergence of Antibiotic Resistance in Acid-Adapted Enterohaemorrhagic Escherichia coli / 10 (5) , 522
3	(2010) The International journal of environmental studies Prevalence of <I>E. coli</I> O157:H7 strains in irrigation water and agricultural soil in two district municipalities in South Africa / 78 (3) , 474
None	(2010) Computers in biology and medicine Gene interaction network to unravel the role of gut bacterial species in cardiovascular diseases: <I>E. coli</I> O157:H7 host-bacterial interaction study / 133 (None) , 104417
1	(2010) IOP conference series : Earth and environmental science Determination of the expiration time of Dangke ripening cheese through physico-chemical and microbiological analysis / 788 (1) , 012094
None	(2010) International journal of food microbiology Genetic diversity and pathogenic potential of Shiga toxin-producing <I>Escherichia coli</I> (STEC) derived from German flour / 347 (None) , 109197
1	(2010) Molecular microbiology OmpR coordinates the expression of virulence factors of Enterohemorrhagic <I>Escherichia coli</I> in the alimentary tract of <I>Caenorhabditis elegans</I> / 116 (1) , 168
19	(2010) Polymers Conductometric Immunosensor for Escherichia coli O157:H7 Detection Based on Polyaniline/Zinc Oxide (PANI/ZnO) Nanocomposite / 13 (19) , 3288
11	(2010) Antibiotics Molecular Modeling the Proteins from the exo-xis Region of Lambda and Shigatoxigenic Bacteriophages / 10 (11) , 1282
46	(2010) Environmental science and pollution research international Protective effect of Beta vulgaris roots supplementation on anemic phenylhydrazine-intoxicated rats / 28 (46) , 65731
4	(2021) Environmental sustainability Antimicrobial resistant bacteria in poultry excrement sold as manure in local markets in Benin / 4 (4) , 873
1	(2021) Nature communications Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic <I>Escherichia coli</I> / 12 (1) , 90
None	(2010) Food control Application of cold plasma and ozone technology for decontamination of <I>Escherichia coli</I> in foods- a review / 130 (None) , 108338
12	(2010) Journal of infection and public health New combination of drugs to combat Escherichia coli DSM1103 QCDSM by reducing antibiotic ciprofloxacin standard dose using response surface methodology / 14 (12) , 1815
1	(2010) npj science of food Genomic analysis of Shiga toxin-producing Escherichia coli O157:H7 from cattle and pork-production related environments / 5 (1) , 15
1	(2010) Communications biology Amynthas corticis genome reveals molecular mechanisms behind global distribution / 4 (1) , 135
6	(2010) Journal of food safety Prevalence and molecular characterization of multidrug‐resistant <I>Escherichia coli</I><SMALL>O157</SMALL> : <SMALL>H7</SMALL> from dairy milk in the Peshawar region of Pakistan / 41 (6) , None
12	(2010) Plants In Vitro Evaluation of Biological Activities and Phytochemical Analysis of Different Solvent Extracts of Punica granatum L. (Pomegranate) Peels / 10 (12) , 2742
None	(2010) Virus research : an international journal of molecular and cellular virology Characterization and genome analysis of a broad lytic spectrum bacteriophage P479 against multidrug-resistant <I>Escherichia coli</I> / 308 (None) , 198628