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Antibacterial and Synergistic Activity of Isocryptomerin Isolated from Selaginella tamariscina  

Lee, June-Young (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Choi, Yun-Jung (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Lee, Dong-Gun (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Publication Information
Journal of Microbiology and Biotechnology / v.19, no.2, 2009 , pp. 204-207 More about this Journal
Abstract
We investigated novel antibacterial and synergistic activities of isocryptomerin isolated from Selaginella tamariscina. Isocryptomerin showed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains including clinical isolates of antibiotic-resistant species such as methicillin-resistant Staphylococcus aureus(MRSA). Additionally, we further investigated the synergistic activity of isocryptomerin with a conventional antibiotic against MRSA. The result indicated that isocryptomerin had considerable synergistic activity in combination with cefotaxime. In summary, the present study suggests that isocryptomerin may have potential as a novel therapeutic agent for treatment of infectious diseases by not only human pathogenic bacteria but also multidrug-resistant bacteria.
Keywords
Isocryptomerin; antibacterial activity; synergistic activity;
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Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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1 Bauer, R. and L. M. Dicks. 2005. Mode of action of lipid IItargeting lantibiotics. Int. J. Food Microbiol. 101: 201-216   DOI   ScienceOn
2 Cassell, G. H. 1997. Emergent antibiotic resistance: Health risks and economic impact. FEMS Immunol. Med. Microbiol. 18: 271- 274   DOI   ScienceOn
3 Cookson, B. 2005. Clinical significance of emergence of bacterial antimicrobial resistance in the hospital environment. J. Appl. Microbiol. 99: 989-996   DOI   PUBMED   ScienceOn
4 Jung, H. J. and D. G. Lee. 2008. Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates. J. Microbiol. 46: 462-467   DOI   ScienceOn
5 Jung, H. J., K.-S. Jeong, and D. G. Lee. 2008. Effective antibacterial action of Tat (47-58) by increased uptake into bacterial cells in the presence of trypsin. J. Microbiol. Biotechnol. 18: 990-996   과학기술학회마을   PUBMED   ScienceOn
6 Lee, S. J., J. H. Choi, K. H. Son, H. W. Chang, S. S. Kang, and H. P. Kim. 1995. Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids. Life Sci. 57: 551-558   DOI   ScienceOn
7 Paterson, D. L. 2006. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin. Infect. Dis. 43(Suppl 2): S43-S48   DOI
8 Roos, K. L. 2004. Emerging antimicrobial-resistant infections. Arch. Neurol. 61: 1512-1514   DOI   PUBMED   ScienceOn
9 White, D. G., S. Zhao, S. Simjee, D. D. Wagner, and P. F. McDermott. 2002. Antimicrobial resistance of foodborne pathogens. Microbes Infect. 4: 405-412   DOI   ScienceOn
10 Kim, H. P., H. Park, K. H. Son, H. W. Chang, and S. S. Kang. 2008. Biochemical pharmacology of biflavonoids: Implications for anti-inflammatory action. Arch. Pharm. Res. 31: 265-273   DOI   ScienceOn
11 Lee, C. W., H. J. Choi, H. S. Kim, D. H. Kim, I. S. Chang, H. T. Moon, S. Y. Lee, W. K. Oh, and E. R. Woo. 2008. Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts. Bioorg. Med. Chem. 16: 732-738   DOI   ScienceOn
12 Hemaiswarya, S., A. K. Kruthiventi, and M. Doble. 2008. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 15: 639-652   DOI   ScienceOn
13 Cha, H. Y., D. C. Moon, C. H. Choi, J. Y. Oh, Y. S. Jeong, Y. C. Lee, et al. 2005. Prevalence of the ST239 clone of methicillin-resistant Staphylococcus aureus and differences in antimicrobial susceptibilities of ST239 and ST5 clones identified in a Korean hospital. J. Clin. Microbiol. 43: 3610-3614   DOI   ScienceOn
14 Sung, W. S., H. J. Jung, I.-S. Lee, H. S. Kim, and D. G. Lee. 2006. Antimicrobial effect of furaneol against human pathogenic bacteria and fungi. J. Microbiol. Biotechnol. 16: 349-354   과학기술학회마을   ScienceOn
15 Silva, G. L., H. Chai, M. P. Gupta, N. R. Farnsworth, G. A. Cordell, J. M. Pezzuto, C. W. Beecher, and A. D. Kinghorn. 1995. Cytotoxic biflavonoids from Selaginella willdenowii. Phytochemistry 40: 129-134   DOI   ScienceOn
16 MacKenzie, F. M., M. J. Struelens, K. J. Towner, and I. M. Gould. 2005. Report of the Consensus Conference on Antibiotic Resistance; Prevention and Control (ARPAC). Clin. Microbiol. Infect. 11: 938-954   DOI   ScienceOn
17 Weber, J. T. and P. Courvalin. 2005. An emptying quiver: Antimicrobial drugs and resistance. Emerg. Infect. Dis. 11: 791-793   PUBMED   ScienceOn
18 Cha, D. S. and M. S. Chinnan. 2004. Biopolymer-based antimicrobial packaging: A review. Crit. Rev. Food Sci. Nutr. 44: 223-237   DOI   ScienceOn
19 Cavalieri, S. J., J. R. Biehle, and W. E. Sanders Jr. 1995. Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 39: 1542-1545   PUBMED   ScienceOn
20 Rice, L. B. 2006. Antimicrobial resistance in Gram-positive bacteria. Am. J. Infect. Control 34(5 Suppl 1): S11-S19   DOI   PUBMED   ScienceOn
21 Kuzin, A. P., H. Liu, J. A. Kelly, and J. R. Knox. 1995. Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillinbinding protein and in extended-spectrum beta-lactamases. Biochemistry 34: 9532-9540   DOI   PUBMED
22 Howard, D. H., R. D. Scott, R. Packard, and D. Jones. 2003. The global impact of drug resistance. Clin. Infect. Dis. 36 (Suppl 1): S4-S10   DOI
23 Bush, K. 2004. Antibacterial drug discovery in the 21st century. Clin. Microbiol. Infect. 10 Suppl 4: 10-17   DOI
24 Lee, J. H., H. Y. Yang, H. S. Lee, and S. K. Hong. 2008. Chemical composition and antimicrobial activity of essential oil from cones of Pinus koraiensis. J. Microbiol. Biotechnol. 18: 497-502   과학기술학회마을   PUBMED
25 Clinical and Laboratory Standards Institute. 2005. Performance Standards for Antimicrobial Susceptibility Testing. Fifteenth Informational Supplement, Approved standard MS 100-S15. CLSI, Wayne, PA
26 Park, K. H., J. S. Kim, Y. R. Lee, Y. J. Moon, H. Hur, Y. H. Choi, et al. 2007. Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action. Exp. Mol. Med. 39: 673-678   DOI   ScienceOn