1 |
Bode, H. B., B. Zeggel, B. Silakowski, S. C. Wenzel, H. Reichenbach, and R. M ller. 2003. Steroid biosynthesis in prokaryotes: Identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol. Microbiol. 47: 471-481
DOI
ScienceOn
|
2 |
Fischer, E. and U. Sauer. 2003. Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS. Eur. J. Biochem. 270: 880-891
DOI
ScienceOn
|
3 |
Gerth, K., D. Schummer, G. Hofle, H. Irschik, and H. Reichenbach. 1995. Ratjadon: A new antifungal compound from Sorangium cellulosum (myxobacteria)-production, physiochemical and biological properties. J. Antibiot. (Tokyo) 48:973-976
DOI
PUBMED
|
4 |
Hardt, I. H., H. Steinmetz, K. Gerth, F. Sasse, H. Reichenbach, and G. Hofle. 2001. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies. J. Nat. Prod. 64: 847-856
DOI
ScienceOn
|
5 |
Irschik, H., R. Jansen, K. Gerth, G. Hofle, and H. Reichenbach. 1995. Chivosazol A, a new inhibitor of eukaryotic organisms isolated from myxobacteria. J. Antibiot. (Tokyo) 48: 962-966
DOI
PUBMED
|
6 |
Irschik, H., R. Jansen, K. Gerth, G. Hofle, and H. Reichenbach. 1995. Disorazol A, an efficient inhibitor of eukaryotic organisms isolated from myxobacteria. J. Antibiot. (Tokyo) 48: 31-35
DOI
PUBMED
ScienceOn
|
7 |
Irschik, H., R. Jansen, K. Gerth, G. Hofle, and H. Reichenbach. 1995. Sorangiolid A, a new antibiotic isolated from the myxobacterium Sorangium cellulosum So ce 12. J. Antibiot. (Tokyo) 48: 886-887
DOI
PUBMED
ScienceOn
|
8 |
Schneiker, S., O. Perlova, A. Alici, M. O. Altmeyer, D. Bartels, T. Bekel, et al. 2007. Complete sequence of the largest known bacterial genome from the myxobacterium Sorangium cellulosum. Nat. Biotechnol. 25: 1281-1289
DOI
ScienceOn
|
9 |
Wittmann, C. and A. de Graaf. 2005. Metabolic flux analysis in Corynebacterium glutamicum, pp. 277-304. In L. Eggeling and M. Bott (eds.), Handbook of Corynebacterium glutamicum. CRC Press, Boca Raton
|
10 |
Watson, B. F. and M. Dworkin. 1968. Comparative intermediary metabolism of vegetative cells and microcysts of Myxococcus xanthus. J. Bacteriol. 96: 1465-1473
PUBMED
|
11 |
Wittmann, C. and E. Heinzle. 2001. Modeling and experimental design for metabolic flux analysis of lysine-producing Corynebacteria by mass spectrometry. Metab. Eng. 3: 173-191
DOI
ScienceOn
|
12 |
Wittmann, C., H. M. Kim, G. John, and E. Heinzle. 2003. Characterization and application of an optical sensor for quantification of dissolved in shake-flasks. Biotechnol. Lett. 25: 377-380
DOI
ScienceOn
|
13 |
Wittmann, C., P. Kiefer, and O. Zelder. 2004. Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source. Appl. Environ. Microbiol. 70: 7277-7287
DOI
ScienceOn
|
14 |
Wittmann, C., M. Hans, and E. Heinzle. 2002. In vivo analysis of intracellular amino acid labelings by GC/MS. Anal. Biochem. 307: 379-382
DOI
ScienceOn
|
15 |
Kromer, J. O., O. Sorgenfrei, K. Klopprogge, E. Heinzle, and C. Wittmann. 2004. In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J. Bacteriol. 186:1769-1784
DOI
ScienceOn
|
16 |
Minnikin, D. E., L. Alshamaony, and M. Goodfellow. 1975. Differentiation of Mycobacterium, Nocardia, and related taxa by thin-layer chromatographic analysis of whole-organism methanolysates. J. Gen. Microbiol. 88: 200-204
DOI
PUBMED
ScienceOn
|
17 |
Noguchi, Y., Y. Nakai, N. Shimba, H. Toyosaki, Y. Kawahara, S. Sugimoto, and E. Suzuki. 2004. The energetic conversion competence of Escherichia coli during aerobic respiration studied by 31P NMR using a circulating fermentation system. J. Biochem. (Tokyo) 136: 509-515
DOI
ScienceOn
|
18 |
Wittmann, C. 2002. Metabolic flux analysis using mass spectrometry. Adv. Biochem. Eng. Biotechnol. 74: 39-64
|
19 |
Gerth, K., S. Pradella, O. Perlova, S. Beyer, and R. M ller. 2003. Myxobacteria: Proficient producers of novel natural products with various biological activities -- past and future biotechnological aspects with the focus on the genus Sorangium. J. Biotechnol. 106: 233-253
DOI
PUBMED
ScienceOn
|
20 |
Reichenbach, H. 1986. The myxobacteria: Common organisms with uncommon behaviour. Microbiol. Sci. 3: 268-274
PUBMED
ScienceOn
|
21 |
Wittmann, C. and E. Heinzle. 2002. Genealogy profiling through strain improvement by using metabolic network analysis: Metabolic flux genealogy of several generations of lysineproducing corynebacteria. Appl. Environ. Microbiol. 68: 5843-5859
DOI
ScienceOn
|
22 |
Gerth, K., N. Bedorf, H. Irschik, G. Hofle, and H. Reichenbach. 1994. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 alpha: Fermentation, isolation, biological properties. J. Antibiot. (Tokyo) 47: 23-31
DOI
PUBMED
|
23 |
Irschik, H., R. Jansen, K. Gerth, G. Hofle, and H. Reichenbach. 1987. The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria. J. Antibiot. (Tokyo) 40: 7-13
DOI
PUBMED
|
24 |
Pradella, S., A. Hans, C. Sproer, H. Reichenbach, K. Gerth, and S. Beyer. 2002. Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56. Arch. Microbiol. 178: 484-492
DOI
ScienceOn
|
25 |
Stouthamer, A. H. 1979. The search for correlation between theoretical and experimental growth yields, pp. 1-47. In J. R. Quayle (ed.), Microbial Biochemistry, Vol. 21. University Park Press, Baltimore
|
26 |
Reichenbach, H. 2001. Myxobacteria, producers of novel bioactive substances. J. Ind. Microbiol. Biotechnol. 27: 149-156
DOI
ScienceOn
|
27 |
Bligh, E. G. and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917
DOI
PUBMED
ScienceOn
|
28 |
Bode, H. B. and R. M ller. 2006. Analysis of myxobacterial secondary metabolism goes molecular. J. Ind. Microbiol. Biotechnol. 33: 577-588
DOI
ScienceOn
|
29 |
Frick, O. and C. Wittmann. 2005. Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb. Cell Fact. 4: 30
DOI
ScienceOn
|
30 |
Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
PUBMED
|
31 |
Mahmud, T., H. B. Bode, B. Silakowski, R. M. Kroppenstedt, M. Xu, S. Nordhoff, G. Hofle, and R. Muller. 2002. A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria. J. Biol. Chem. 277: 32768-32774
DOI
ScienceOn
|
32 |
Bacon, K., D. Clutter, R. H. Kottel, M. Orlowski, and D. White. 1975. Carbohydrate accumulation during myxospore formation in Myxococcus xanthus. J. Bacteriol. 124: 1635-1636
PUBMED
|
33 |
Bollag, D. M. 1997. Epothilones: Novel microtubule-stabilising agents. Expert Opin. Investig. Drugs 6: 867-873
DOI
ScienceOn
|
34 |
Gerth, K., N. Bedorf, G. Hofle, H. Irschik, and H. Reichenbach. 1996. Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physicochemical and biological properties. J. Antibiot. (Tokyo) 49: 560-563
DOI
PUBMED
|
35 |
Pirt, S. J. 1965. The maintenance energy of bacteria in growing cultures. Proc. R. Soc. Lond. B Biol. Sci. 163: 224-231
DOI
PUBMED
ScienceOn
|
36 |
Thomas, E., J. Tabernero, M. Fornier, P. Conte, P. Fumoleau, A. Lluch, et al. 2007. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxaneresistant metastatic breast cancer. J. Clin. Oncol. 25: 3399-3406
DOI
ScienceOn
|
37 |
Wittmann, C. and E. Heinzle. 1999. Mass spectrometry for metabolic flux analysis. Biotechnol. Bioeng. 62: 739-750
DOI
ScienceOn
|
38 |
Wittmann, C., H. M. Kim, and E. Heinzle. 2004. Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale. Biotechnol. Bioeng. 87: 1-6
DOI
ScienceOn
|
39 |
Gombert, A. K., M. Moreira dos Santos, B. Christensen, and J. Nielsen. 2001. Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol. 183:1441-1451
DOI
ScienceOn
|
40 |
Kromer, J. O., M. Fritz, E. Heinzle, and C. Wittmann. 2005. In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Anal. Biochem. 340: 171-173
DOI
ScienceOn
|
41 |
Sauer, U., F. Canonaco, S. Heri, A. Perrenoud, and E. Fischer. 2004. The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli. J. Biol. Chem. 279: 6613-6619
DOI
ScienceOn
|
42 |
Sauer, U. and B. J. Eikmanns. 2005. The PEP-pyruvateoxaloacetate node as the switch point for carbon flux distribution in bacteria. FEMS Microbiol. Rev. 29: 765-794
DOI
ScienceOn
|
43 |
Hofman, U. 1989. Physiologische Studien an Sorangium cellulosum, So ce 12. Technical University, Braunschweig
|
44 |
van Winden, W. A., C. Wittmann, E. Heinzle, and J. J. Heijnen. 2002. Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol. Bioeng. 80: 477-479
DOI
ScienceOn
|
45 |
Dauner, M., J. E. Bailey, and U. Sauer. 2001. Metabolic flux analysis with a comprehensive isotopomer model in Bacillus subtilis. Biotechnol. Bioeng. 76: 144-156
DOI
ScienceOn
|
46 |
Becker, J., C. Klopprogge, O. Zelder, E. Heinzle, and C. Wittmann. 2005. Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources. Appl. Environ. Microbiol. 71: 8587-8596
DOI
ScienceOn
|
47 |
Bollag, D. M., P. A. McQueney, J. Zhu, O. Hensens, L. Koupal, J. Liesch, M. Goetz, E. Lazarides, and C. M. Woods. 1995. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55: 2325-2333
PUBMED
ScienceOn
|