Browse > Article
http://dx.doi.org/10.4014/jmb.0906.06033

Reticulone, a Novel Free Radical Scavenger Produced by Aspergillus sp.  

Ryoo, In-Ja (Korea Research Institute of Bioscience and Biotechnology)
Xu, Guang-Hua (Korea Research Institute of Bioscience and Biotechnology)
Kim, Young-Hee (Korea Research Institute of Bioscience and Biotechnology)
Choo, Soo-Jin (Korea Research Institute of Bioscience and Biotechnology)
Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.19, no.12, 2009 , pp. 1573-1575 More about this Journal
Abstract
Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compounds: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analyses. Compound 1 exhibited more potent free radical scavenging activity on $ABTS^{\cdot+}$ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid.
Keywords
Aspergillus sp.; reticulone; DPPH; ABTS;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 0  (Related Records In Web of Science)
연도 인용수 순위
1 Moon, B. S., I. J. Ryoo, B. S. Yun, K. S. Bae, K. D. Lee, I. D. Yoo, and J. P. Kim. 2006. Glyscavins A, B, and C, new phenolic glycoside antioxidants produced by a fungus Mycelia sterilia F020054. J. Antibiot. 59: 735-739   DOI   PUBMED
2 Pietta, P. G. 2000. Flavonoids as antioxidants. J. Nat. Prod. 63: 1035-1042   DOI   PUBMED   ScienceOn
3 Diaz, M. N., B. Frei, J. A. Vita, and J. F. Keaney. 1997. Antioxidants and atherosclerotic heart disease. N. Eng. J. Med. 337: 408-416   DOI   ScienceOn
4 Choo, S. J., H. R. Park, I. J. Ryoo, J. P. Kim, B. S. Yun, C. J. Kim, K. Shinya, and I. D. Yoo. 2005. Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. J. Antibiot. 58: 210-213   DOI   ScienceOn
5 Coyle, J. T. and P. Puttfarcken. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695   DOI   PUBMED   ScienceOn
6 Lim, D. S., Y. S. Kwak, J. H. Kim, S. H. Ko, W. H. Yoon, and C. H. Kim. 2003. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy 49: 146-153   DOI   ScienceOn
7 Mitscher, L. A., W. W. Andres, and W. McCrae. 1964. Reticulol, a new metabolic isocoumarin. Experientia 20: 258-259   DOI   PUBMED   ScienceOn
8 Kim, Y. H., S. M. Cho, J. W. Hyun, I. J. Ryoo, S. J. Choo, S. Lee, and I. D. Yoo. 2008. Clitocybin A, a new antioxidative compound from the culture broth of Clitocybe aurantiaca. J. Antibiot. 61: 573-576   DOI   ScienceOn
9 Yoo, N. H., I. D. Yoo, J. W. Kim, B. S. Yun, I. J. Ryoo, E. S. Yoon, T. C. Nguyen, and J. P. Kim. 2005. Sterin C, a new antioxidant from the mycelial culture of the mushroom Stereum hirsutum. Agric. Chem. Biotechnol. 48: 38-41   ScienceOn
10 Arnone, A., A. Colombo, G. Nasini, and S. V. Meille. 1993. Eleganthol, a sesquiterpene from Clitocybe elegans. Phytochemistry 32: 1493-1497   DOI   ScienceOn
11 Halliwell, B. and J. M. C. Gutteridge. 1999. Free Radicals in Biology and Medicine, pp. 617-683, 3rd Ed. Oxford University Press, New York
12 Fraga, G., M. K. Shigenage, J. W. Park, P. Degan, and B. N. Ames. 1990. Oxidative damage to DNA during aging: 8-Hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. U.S.A. 87: 4533-4537   DOI   ScienceOn