Production of Gamma-Linolenic Acid in Pichia pastoris by Expression of a Delta-6 Desaturase Gene from Cunninghamella echinulata
![]() |
Wan, Xia
(Oil Crops Research Institute, Chinese Academy of Agricultural Sciences)
Zhang, Yinbo (Oil Crops Research Institute, Chinese Academy of Agricultural Sciences) Wang, Ping (Oil Crops Research Institute, Chinese Academy of Agricultural Sciences) Huang, Fenghong (Oil Crops Research Institute, Chinese Academy of Agricultural Sciences) Chen, Hong (Oil Crops Research Institute, Chinese Academy of Agricultural Sciences) Jiang, Mulan (Oil Crops Research Institute, Chinese Academy of Agricultural Sciences) |
1 |
Fakas, S., M. Čertik, S. Papanikolaou, G. Aggelis, M. Komaitis, and M. Galiotou-Panayotou. 2008. |
2 | Flowers, M. T. and J. M. Ntambi. 2008. Role of stearoylcoenzyme A desaturase in regulating lipid metabolism. Curr. Opin. Lipidol. 19: 248-256 DOI ScienceOn |
3 |
Hisashi, Y., I. Hitoshi, K. Yasushi, K. Kazuyoshi, A. Tsunehiro, O. Kazuhisa, and U Hiroshi. 2007. Heterologous production of dihomo- |
4 |
Horrobin, D. F. 1992. Nutritional and medical importance of |
5 | Horrobin, D. F. 1993. Fatty acid metabolism in health and disease:The role of delta-6 desaturase. Am. J. Clin. Nutr. 57: 732-736 |
6 | Kapoor, R. and Y. S. Huang. 2006. Gamma linolenic acid: An anti-inflammatory omega-6 fatty acid. Curr. Pharm. Biotechnol. 7: 531-534 DOI ScienceOn |
7 |
Ranong, S. N., K. Laoteng, P. Kittakoop, M. Tanticharoen, and S. Cheevadhanarak. 2006. Targeted mutagenesis of a fatty acid |
8 | Wang, H., Z. Deng, S. Zhou, and X. Zhang. 2007. Using potato starch wastewater to produce GLA with Cunninghamella echinulata. China Oils Fats (Chinese) 32: 49-51 |
9 |
Zhang, Q., M. Li, H. Ma, Y. Sun, and L. Xing. 2004. Identification and characterization of a novel |
10 |
Chen, R., S. Tsuda, K. Matsui, M. Fukuchi-Mizutani, M. Ochiai, S. Shimizu, et al. 2005. Production of |
11 | Tao, J., L. Zhao, X. Zhang, S. Zhang, H. Wang, and Y. Gu. 2007. Growth law of gamma-linolenic acid production by Cunninghamella echinulata. J. U.S. China Med. Sci. 4: 55-60 |
12 | Fakas, S., S. Papanikolaou, M. Galiotou-Panayotou, M. Komaitis, and G. Aggelis. 2008. Organic nitrogen of tomato waste hydrolysate enhances glucose uptake and lipid accumulation in Cunninghamella echinulata. J. Appl. Microbiol. 105: 1062-1070 DOI ScienceOn |
13 |
Laoteng, K., R. Mannontarat, M. Tanticharoen, and S. Cheevadhanarak. 2000. |
14 | Wang, D., M. Li, D. Wei, Y. Cai, Y. Zhuang, and L. Xing. 2007. Identification and functional characterization of the delta-6 fatty acid desaturase gene from Thamnidium elegans. J. Eukaryot. Microbiol. 54: 110-117 DOI ScienceOn |
15 | Vrinten, P., G. Wu, M. Truksa, and X. Qiu. 2007. Production of polyunsaturated fatty acids in transgenic plants. Biotechnol. Genet. Eng. Rev. 24: 263-279 DOI PUBMED ScienceOn |
16 | Shanklin, J., E. Whittle, and B. G. Fox. 1994. Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-coA desaturase, and are conserved in alkane hydroxylase and xylase monooxygenase. Biochemistry 33: 12787-12794 DOI ScienceOn |
17 |
Sayanova, O. and M. A. Smith. 1997. Expression of a borage desaturase cDNA containing an N-terminal cytochrome |
18 | Sperling, P., H. Schmidt, and E. Heinz. 1995. A cytochrome-b5-containing fusion protein similar to plant acyl lipid desaturase. Eur. J. Biochem. 232: 798-805 ScienceOn |
19 |
Fakas, S., S. Papanikolaou, M. Galiotou-Panayotou, M. Komaitis, and G. Aggelis. 2006. Lipids of Cunninghamella echinulata with emphasis to |
20 |
Sakuradani, E., M. Kobayashi, and S. Shimizu. 1999. |
21 | Liang, S., X. Zhang, and H. Wang. 2004. Study on metabolic law of gamma-linolenic acid produced by Cunninghamella echinulata. Biotechnol. (Chinese) 14: 48-50 |
22 | Hong, H., N. Datla, D. W. Reed, P. S. Covello, S. L. Mackenzie, and X. Qiu. 2002. High-level production of gammalinolenic acid in Brassica juncea using a delta-6 desaturase from Pythium irregulare. Plant Physiol. 129: 354-362 DOI PUBMED ScienceOn |
23 |
Chen, H. and C. Chang. 1996. Production of |
24 |
Fan, Y. Y. and R. S. Chapkin. 1998. Importance of dietary |
25 | Dyer, J. M., S. Stymne, A. G. Green, and A. S. Carlsson. 2008. High-value oils from plants. Plant J. 54: 640-655 DOI ScienceOn |
26 |
Gema, H., A. Kavadia, D. Dimou, V. Tsagou, M. Komaitis, and G. Aggelis. 2002. Production of |
27 |
Sakuradani, E. and S. Shimizu. 2003. Gene cloning and functional analysis of a second |
![]() |