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Control of Tylosin Biosynthesis in Streptomyces fradiae  

Cundliffe, Eric (Department of Biochemistry. University of Leicester)
Publication Information
Journal of Microbiology and Biotechnology / v.18, no.9, 2008 , pp. 1485-1491 More about this Journal
Abstract
Tylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement of the signalling ligand is not essential for tylosin biosynthesis.
Keywords
Antibiotic production; gamma-butyrolactone; gene regulation; Streptomyces; tylosin;
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