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Antifungal Effect of Silver Nanoparticles on Dermatophytes  

Kim, Keuk-Jun (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Sung, Woo-Sang (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Moon, Seok-Ki (Department of Dermatology, College of Medicine, Yeungnam University)
Choi, Jong-Soo (Department of Dermatology, College of Medicine, Yeungnam University)
Kim, Jong-Guk (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Lee, Dong-Gun (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Publication Information
Journal of Microbiology and Biotechnology / v.18, no.8, 2008 , pp. 1482-1484 More about this Journal
Abstract
Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species ($IC_{80}$, 1-7${\mu}g/ml$). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B $IC_{80}$, 1-5${\mu}g/ml$; fluconazole $IC_{80}$, 10-30${\mu}g/ml$). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.
Keywords
Silver nanoparticles; antifungal effect; Trichophyton mentagrophytes; Candida species;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 34  (Related Records In Web of Science)
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