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Nuruk Extract Inhibits Lipopolysaccharide-Induced Production of Nitrite and Interleukin-6 in RAW 264.7 Cells Through Blocking Activation of p38 Mitogen-Activated Protein Kinase  

Kim, Jong-Eun (Department of Agricultural Biotechnology, Seoul National University)
Jung, Sung-Keun (Department of Agricultural Biotechnology, Seoul National University)
Lee, Sang-Jin (Research Laboratory, Kooksoondang Brewery Co., Ltd.)
Lee, Ki-Won (Department of Bioscience and Biotechnology, Konkuk University)
Kim, Gye-Won (Research Laboratory, Kooksoondang Brewery Co., Ltd.)
Lee, Hyong-Joo (Department of Agricultural Biotechnology, Seoul National University)
Publication Information
Journal of Microbiology and Biotechnology / v.18, no.8, 2008 , pp. 1423-1426 More about this Journal
Abstract
Nuruk, which is a natural inoculator and source of amylolytic enzymes, is used in Korean traditional rice wine. A methanol extract of nuruk (NE) attenuated lipopolysaccharide (LPS)-induced nitrite and interleukin (IL)-6 in RAW 264.7 cells. Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells. MEH and MW also inhibited the LPS-induced inducible nitric oxide synthase expression. Further, and MEH protected against the LPS-induced activation of p38 mitogen-activated protein kinase. Together, these results indicate that nuruk may contribute to the anti-inflammatory and cancer-preventive effects of Korean traditional rice wine.
Keywords
Anti-inflammation; inducible nitric oxide synthase; nuruk;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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