Functional Effects of Increased Copy Number of the Gene Encoding Proclavaminate Amidino Hydrolase on Clavulanic Acid Production in Streptomyces clavuligerus ATCC 27064 |
Song, Ju-Yeon
(School of Biological Sciences, Seoul National University)
Kim, Eun-Sook (School of Biological Sciences, Seoul National University) Kim, Dae-Wi (School of Biological Sciences, Seoul National University) Jesen, Susan E. (Department of Biological Sciences, University of Alberta) Lee, Kye-Joon (School of Biological Sciences, Seoul National University) |
1 | Foulstone, M. and C. Reading. 1982. Assay of amoxycillin and clavulanic acid, the components Augmentin, in biological fluids with high performance liquid chromatography. Antimicrob. Agents Chemother. 22: 753-762 DOI ScienceOn |
2 | Jensen, S. E., A. Wong, A. Griffin, and B. Barton. 2004. Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Antimicrob. Agents Chemother. 48: 514-520 DOI ScienceOn |
3 | Kieser, T., M. J. Bibb, M. J. Butter, K. F. Chater, and D. A. Hopwood. 2000. Practical Streptomyces Genetics. The John Innes Foundation, Norwich |
4 | Nicholson, N. H., K. H. Baggaley, R. Cassels, M. Davison, S. W. Elson, M. Fulston, J. W. Tyler, and S. R. Woroniecki. 1994. Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analog. J. Chem. Soc. Chem. Commun. 1994: 1281-1282 |
5 | Ryu, Y. G., W. Jin, J. Y Kim, J. Y. Kim, S. H. Lee, and K. J. Lee. 2004. Stringent factor regulates antibiotics production and morphological differentiation of Streptomyces clavuligerus. J. Microbiol. Biotechnol. 14: 1170-1175 |
6 | Saudagar, P. S. and R. S. Singhal. 2007. Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus. Bioresour. Technol. 98: 2010-2017 DOI ScienceOn |
7 | Tahlan, K., C. Anders, and S. E. Jensen. 2004. The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J. Bacteriol. 186: 6286-6297 DOI ScienceOn |
8 | Vara, J., M. Lewandowska-Skarbek, Y. G. Wang, S. Donadio, and C. R. Hutchinson. 1989. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 171: 5872-5881 DOI |
9 | Wu, T. K., R. W. Busby, T. A. Houston, D. B. McIlwaine, L. A. Egan, and C. A. Townsend. 1995. Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. J. Bacteriol. 177: 3714-3720 DOI |
10 | Bachmann, B. O., R. Li, and C. A Townsend. 1998. -Lactam synthetase: A new biosynthetic enzyme. Proc. Natl. Acad. Sci. USA 95: 9082-9086 |
11 | Hung, T. V., S. Malla, B. C. Park, K. Kiou, H. C. Lee, and J. K. Sohng. 2007. Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. J. Microbiol. Biotechnol. 17: 1538-1545 과학기술학회마을 |
12 | Brown, A. G., D. Butterworth, M. Cole, G. Hanscombe, J. D. Hood, C. Reading, and G. N. Rolison. 1976. Naturally occurring -lactamase inhibitors with antibacterial activity. J. Antibiot. 29: 668-669 DOI |
13 | Ishida, K., T. V. Hung, H. C. Lee, K. Liou, C. H. Shin, Y. J. Yoon, and J. K. Sohng. 2006. Degradation of clavulanic acid during the cultivation of Streptomyces clavuligerus; Instability of clavulanic acid by metabolites and proteins from the strain. J. Microbiol. Biotechnol. 16: 590-596 과학기술학회마을 |
14 | Ouzounis, C. A. and N. C. Kyrpides. 1994. On the evolution of arginases and related enzymes. J. Mol. Evol. 39: 101-104 |
15 | Sambrook, J., E. F. Fritsch, and T. Maniatis. 2001. Molecular Cloning: A Laboratory Manual, 3rd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. |
16 | Baldwin, J. E., R. M. Adlington, J. S. Bryans, A. O. Bringhen, J. B. Coates, N. P. Crouch, M. D. Lloyd, C. J. Schofield, S. W. Elson, K. H. Baggaley, R. Cassels, and N. H. Nicholson. 1991. Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid. Tetrahedron 47: 4089-4100 DOI ScienceOn |
17 | Gust, B., G. Chandra, D. Jakimowicz, T. Yuqing, C. J. Bruton, and K. F. Chater. 2004. Lambda red-mediated genetic manipulation of antibiotic producing Streptomyces. Adv. Appl. Microbiol. 54: 107-128 DOI |
18 | Salowe, S. P., W. J. Krol, D. Iwata-Reuyl, and C. A. Townsend. 1991. Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry 30: 2281-2292 DOI ScienceOn |
19 | Perez-Redondo, R., A. Rodriguez-Garcia, J. F. Martin, and P. Liras. 1999. Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit. J. Bacteriol. 181: 6922-6928 |
20 | Quesenberry, M. S. and Y. C. Lee. 1996. A rapid formaldehyde assay using purpald reagent: Application under periodation conditions. Anal. Biochem. 234: 50-55 DOI ScienceOn |
21 | Perez-Redondo, R., A. Rodriguez-Garcia, J. F. Martin, and P. Liras. 1998. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene 211: 311-321 DOI ScienceOn |
22 | Paradkar, A. S., K. A. Aidoo, and S. E. Jensen. 1998. A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus. Mol. Microbiol. 27: 831-843 DOI ScienceOn |
23 | Bierman, M., R. Logan, K. O'Brien, E. T. Seno, R. N. Rao, and B. E. Schoner. 1992. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116: 43-49 DOI ScienceOn |
24 | Elson, S. W., K. H. Baggaley, M. Davison, M. Fulston, N. H. Nicholson, G. D. Risbridger, and J. W. Tyler. 1993. The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway. J. Chem. Soc. Chem. Commun. 1993: 1212-1214 |
25 | Mellado, E., L. M. Lorenzana, M. Rodriguez-Saiz, B. Diez, P. Liras, and J. L. Barredo. 2002. The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: Genetic organization of the region upstream of the car gene. Microbiology 148: 1427-1438 DOI |
26 | Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166: 557-580 DOI |
27 | Romero, J., P. Liras, and J. F. Martin. 1984. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 20: 318-325 DOI |
28 | Pirt, S. J. 1975. Parameters of growth and analysis of growth data, pp. 4-14. In: Principles of Microbe and Cell Cultivation. Blackwell, Oxford, U.K. |
29 | Khaleeli, N., R. Li, and C. A. Townsend. 1999. Origin of the -lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction. J. Am. Chem. Soc. 121: 9223-9224 DOI ScienceOn |
30 | Perez-Llarena, F. J., P. Liras, A. Rodriguez-Garcia, and J. F. Martin. 1997. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both beta-lactam compounds. J. Bacteriol. 179: 2053-2059 DOI |
31 | Marsh, E. N., M. D. Chang, and C. A. Townsend. 1992. Two isozymes of clavaminate synthase central to clavulanic acid formation: Cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry 31: 12648-12657 DOI ScienceOn |
32 | Ives, P. R. and M. E. Bushell. 1997. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology 143: 3573-3579 DOI ScienceOn |
33 | Salowe, S. P., E. N. Marsh, and C. A. Townsend. 1990. Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: An unusual oxidative enzyme in natural product biosynthesis. Biochemistry 29: 6499-6508 DOI ScienceOn |
34 | MacNeil, D. J., K. M. Gewain, C. L. Ruby, G. Dezeny, P. H. Gibbons, and T. MacNeil. 1992. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68 DOI ScienceOn |
35 | Paradkar, A. S., R. H. Mosher, C. Anders, A. Griffin, J. Griffin, C. Hughes, P. Greaves, B. Barton, and S. E. Jensen. 2001. Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production. Appl. Environ. Microbiol. 67: 2292-2297 DOI ScienceOn |
36 | Valentine, B. P., C. R. Bailey, A. Doherty, J. Morris, S. W. Elson, K. H. Baggaley, and N. H. Nicholson. 1993. Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus. J. Chem. Soc. Chem. Commun. 1993: 1210-1211 |
37 | Datsenko, K. A. and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97: 6640-6645 |