[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.0800.489

Effects of Astaxanthin on the Production of NO and the Expression of COX-2 and iNOS in LPS-Stimulated BV2 Microglial Cells

Choi, Seok-Keun (Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University)
Park, Young-Sam (Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University)
Choi, Dong-Kug (Department of Biotechnology, Konkuk University)
Chang, Hyo-Ihl (Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University)

Publication Information

Journal of Microbiology and Biotechnology / v.18, no.12, 2008 , pp. 1990-1996 More about this Journal

Abstract

Astaxanthin has shown antioxidant, antitumor, and anti-inflammatory activities; however, its molecular action and mechanism in the nervous system have yet to be elucidated. We examined the in vitro effects of astaxanthin on the production of nitric oxide (NO), as well as the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Astaxanthin inhibited the expression or formation of nitric oxide (NO), iNOS and COX-2 in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Astaxanthin also suppressed the protein levels of iNOS and COX-2 in LPS-stimulated BV2 microglial cells. These results suggest that astaxanthin, probably due to its antioxidant activity, inhibits the production of inflammatory mediators by blocking iNOS and COX-2 activation or by the suppression of iNOS and COX-2 degradation.

Keywords

Astaxanthin; anti-inflammatory activity; BV2 microglial cell; Infalmmatory mediator;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)
Times Cited By Web Of Science : 11 (Related Records In Web of Science)

Reference
Cited By KSCI

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