Browse > Article
http://dx.doi.org/10.4014/jmb.0800.203

Involvement of ${\beta}$-Lactamase Inhibitory Protein, BLIP-II, in Morphological Differentiation of Streptomyces exfoliatus SMF19  

Kim, Eun-Sook (School of Biological Sciences, Seoul National University)
Song, Ju-Yeon (School of Biological Sciences, Seoul National University)
Kim, Dae-Wi (School of Biological Sciences, Seoul National University)
Ko, Eun-Ji (School of Biological Sciences, Seoul National University)
Jensen, Susan E. (Department of Biological Sciences, University of Alberta)
Lee, Kye-Joon (School of Biological Sciences, Seoul National University)
Publication Information
Journal of Microbiology and Biotechnology / v.18, no.12, 2008 , pp. 1884-1889 More about this Journal
Abstract
The ${\beta}$-lactamase inhibitory protein, BLIP-II, found in the culture supernatant of Streptomyces exfoliatus SMF19, shows no discernible sequence identity with other ${\beta}$-lactamase inhibitory proteins identified in Streptomyces spp. A null mutant of the gene encoding BLIP-II (bliB::$hyg^r$) showed a bald appearance on solid media. Although BLIP-II was initially isolated from the supernatant of submerged cultures, sites of BLIP-II accumulation were seen in the cell envelope. Mutation of bliB was also associated with changes in the formation of septa and condensation of the chromosomal DNA associated with sporulation. The bliB mutant exhibited infrequent septa, showing dispersed chromosomal DNA throughout the mycelium, whereas the condensed chromosomes of the wild-type were separated by regularly spaced septa giving the appearance of a string of beads. Therefore, on the basis of these results, it is suggested that BLIP-II is a regulator of morphological differentiation in S. exfoliatus SMF19.
Keywords
Streptomyces exfoliatus SMF19; BLIP-II; morphological differentiation;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
연도 인용수 순위
  • Reference
1 Doran, J. L., B. K. Leskiw, S. Aippersbach, and S. E. Jensen. 1990. Isolation and characterization of a $\beta$-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene. J. Bacteriol. 172: 4909-4918   DOI
2 Kahan, J. S., F. M. Kahan, R. Goegelman, S. A. Currie, M. Jackson, E. O. Stapley, et al. 1979. Thienamycin, a new $\beta$- lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties. J. Antibiot. 32: 1-12   DOI
3 Kelly, J. A., O. Dideberg, P. Charlier, J. P. Wery, M. Libert, P. C. Moews, et al. 1986. On the origin of bacterial resistance to penicillin: Comparison of a $\beta$-lactamase and a penicillin target. Science 231: 1429-1431   DOI
4 Kim, M. K. and K. J. Lee. 1994. Characteristics of $\beta$-lactamase inhibiting proteins from Streptomyces exfoliatus SMF19. Appl. Environ. Microbiol. 60: 1029-1032
5 Matsumoto, T. and D. Beach. 1991. Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell 66: 347-360   DOI   ScienceOn
6 Moore, J. D. 2001. The Ran-GTPase and cell-cycle control. Bioessays 23: 77-85   DOI   ScienceOn
7 Ohtsubo, M., R. Kai, N. Furuno, T. Sekiguchi, M. Sekiguchi, H. Hayashida, et al. 1987. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Genes Dev. 1: 585-593   DOI   ScienceOn
8 Rudgers, G. W. and T. Palzkill. 1999. Identification of residues in $\beta$-lactamase critical for binding $\beta$-lactamase inhibitory protein. J. Biol. Chem. 274: 6963-6971   DOI   ScienceOn
9 Samraoui, B., B. J. Sutton, R. J. Todd, P. J. Artymiuk, S. G. Waley, and D. C. Phillips. 1986. Tertiary structural similarity between a class A $\beta$-lactamase and a penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase. Nature 320: 378-380   DOI   ScienceOn
10 Butterworth, D., M. Cole, G. Hanscomb, and G. N. Rolinson. 1979. Olivanic acids, a family of $\beta$-lactam antibiotics with $\beta$-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies. J. Antibiot. 32: 287-294   DOI
11 Petrosino, J., C. Cantu, 3rd. and T. Palzkill. 1998. $\beta$-lactamases: Protein evolution in real time. Trends Microbiol. 6: 323-327   DOI   ScienceOn
12 Blazquez, J., M. R. Baquero, R. Canton, I. Alos, and F. Baquero. 1993. Characterization of a new TEM-type $\beta$-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli. Antimicrob. Agents Chemother. 37: 2059-2063   DOI   ScienceOn
13 Petrosino, J., G. Rudgers, H. Gilbert, and T. Palzkill. 1999. Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of $\beta$-lactamases. J. Biol. Chem. 274: 2394-2400   DOI   ScienceOn
14 Sazer, S. and P. Nurse. 1994. A fission yeast RCC1-related protein is required for the mitosis to interphase transition. EMBO J. 13: 606-615
15 Cole, C. N. and C. M. Hammell. 1998. Nucleocytoplasmic transport: Driving and directing transport. Curr. Biol. 8: R368-R372   DOI   ScienceOn
16 Strynadka, N. C., S. E. Jensen, K. Johns, H. Blanchard, M. Page, A. Matagne, J. M. Frère, and M. N. James. 1994. Structural and kinetic characterization of a $\beta$-lactamase-inhibitor protein. Nature 368: 657-660   DOI
17 Park, H. U. and K. J. Lee. 1998. Cloning and heterologous expression of the gene for BLIP-II, a $\beta$-lactamase-inhibitory protein from Streptomyces exfoliatus SMF19. Microbiology 144: 2161-2167   DOI
18 Neu, H. C. 1992. The crisis in antibiotic resistance. Science 257: 1064-1073   DOI   ScienceOn
19 Kieser, T., M. J. Bibb, M. J. Buttner, K. F. Chater, and D. A. Hopwood. 2000. Practical Streptomyces Genetics. John Innes Foundation, Norwich
20 Reynolds, K. A., J. M. Thomson, K. D. Corbett, C. R. Bethel, J. M. Berger, J. F. Kirsch, R. A. Bonomo, and T. M. Handel. 2006. Structural and computational characterization of the SHV- 1 $\beta$-lactamase-$\beta$-lactamase inhibitor protein interface. J. Biol. Chem. 281: 26745-26753   DOI   ScienceOn
21 Gordon, G. B., L. R. Miller, and K. G. Bensch. 1963. Fixation of tissue culture cells for ultrastructural cytochemistry. Exp. Cell Res. 31: 440-443   DOI   ScienceOn
22 Brown, A. G., D. Butterworth, M. Cole, G. Hanscomb, J. D. Hood, C. Reading, and G. N. Rolinson. 1976. Naturally-occurring $\beta$-lactamase inhibitors with antibacterial activity. J. Antibiot. 29: 668-669   DOI
23 Therrien, C. and R. C. Levesque. 2000. Molecular basis of antibiotic resistance and $\beta$-lactamase inhibition by mechanismbased inactivators: Perspectives and future directions. FEMS Microbiol. Rev. 24: 251-262   DOI
24 Schwedock, J., J. R. McCormick, E. R. Angert, J. R. Nodwell, and R. Losick. 1997. Assembly of the cell division protein FtsZ into ladder-like structures in the aerial hyphae of Streptomyces coelicolor. Mol. Microbiol. 25: 847-858   DOI   ScienceOn
25 Wang, J., Z. Zhang, T. Palzkill, and D. C. Chow. 2007. Thermodynamic investigation of the role of contact residues of $\beta$-lactamase-inhibitory protein for binding to TEM-1 $\beta$-lactamase. J. Biol. Chem. 282: 17676-17684   DOI   ScienceOn
26 Kang, S. G., H. U. Park, H. S. Lee, H. T. Kim, and K. J. Lee. 2000. New $\beta$-lactamase inhibitory protein (BLIP-I) from Streptomyces exfoliatus SMF19 and its roles on the morphological differentiation. J. Biol. Chem. 275: 16851-16856   DOI   ScienceOn
27 Lim, D., H. U. Park, L. De Castro, S. G. Kang, H. S. Lee, S. Jensen, K. J. Lee, and N. C. Strynadka. 2001. Crystal structure and kinetic analysis of $\beta$-lactamase inhibitor protein-II in complex with TEM-1 $\beta$-lactamase. Nat. Struct. Biol. 8: 848-852   DOI   ScienceOn
28 Kim, M. K., H. I. Kang, and K. J. Lee. 1991. Purification and characterization of proteinaceous $\beta$-lactamase inhibitor from the culture broth of Streptomyces sp. SMF19. J. Microbiol. Biotechnol. 1: 85-89