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Anti-inflammatory Effects of Recombinant Arginine Deiminase Originating from Lactococcus lactis ssp. lactis ATCC 7962  

Kim, Jong-Eun (Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University)
Hur, Haeng-Jeon (Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University)
Lee, Ki-Won (Department of Bioscience and Biotechnology and Institute of Biomedical Science and Technology, Konkuk University)
Lee, Hyong-Joo (Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University)
Publication Information
Journal of Microbiology and Biotechnology / v.17, no.9, 2007 , pp. 1491-1497 More about this Journal
Abstract
Arginine deiminase (ADI, E.C. 3.5.3.6), one of the arginine deprivation enzymes, exhibits anticarcinogenic activities. The present study investigated the anti-inflammatory activities of the purified recombinant ADI originating from Lactococcus lactis ssp. lactis ATCC7962 (LADI). LADI dose-dependently inhibited lipopolysaccharide (LPS)-induced upregulation of inducible nitric oxide synthase and the production of nitric oxide in RAW 264.7 murine macrophages. The induction of cyclooxygenase-2 expression and subsequent production of prostaglandin $E_2$ by LPS was also attenuated by LADI treatment. Moreover, LADI inhibited the production of interleukin-6 in LPS-stimulated RAW 264.7 macrophages. These results indicate that LADI exerts anti-inflammatory effects, which may in part explain its chemopreventive potential.
Keywords
Arginine deiminase; lactic acid bacteria; inducible nitric oxide synthase; cyc1ooxygenase-2; interleukin-6;
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