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Antimicrobial Effects of Flavone Analogues and Their Structure-Activity Relationships  

Young, Jung-Mo (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Park, Young-Hee (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Lee, Yong-Uk (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Kim, Ho-Jung (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Shim, Yhong-Hee (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Ahn, Joong-Hoon (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Lim, Yoong-Ho (Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University)
Publication Information
Journal of Microbiology and Biotechnology / v.17, no.3, 2007 , pp. 530-533 More about this Journal
Abstract
It has been well known that the use of Saccharomyces cerevisiae can cause fungemia in critically ill patients and flavone shows an antimicrobial effect on S. cerevisiae. Therefore, we have investigated the activities of thirteen flavone analogues on S. cerevisiae in our studies. Because flavonoids including flavones have antioxidative effects, we try to carry out the activity studies of flavone analogues in vitro and in vivo. In addition, the relationships between the structures of flavone analogues and their biological activities, such as antimicrobial and antioxidative effects, were elucidated using Comparative Molecular Field Analysis calculations. Of the flavone analogues tested here, 3,2'-dihydroxyflavone showed both good antimicrobial and antioxidative activities.
Keywords
Antimicrobial; flavonoid; Saccharomyces cerevisiae; Caenorhabditis elegans; antioxidative effect;
Citations & Related Records
Times Cited By KSCI : 10  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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