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Biosynthesis of Bile Acids in a Variety of Marine Bacterial Taxa  

Kim, Doc-Kyu (Korea Research Institute of Bioscience and Biotechnology)
Lee, Jong-Suk (Korea Research Institute of Bioscience and Biotechnology)
Kim, Ji-Young (Korea Research Institute of Bioscience and Biotechnology)
Kang, So-Jung (Korea Research Institute of Bioscience and Biotechnology)
Yoon, Jung-Hoon (Korea Research Institute of Bioscience and Biotechnology)
Kim, Won-Gon (Korea Research Institute of Bioscience and Biotechnology)
Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.17, no.3, 2007 , pp. 403-407 More about this Journal
Abstract
Several marine. bacterial strains, which were isolated from seawater off the island Dokdo, Korea, were screened to find new bioactive compounds such as antibiotics. Among them, Donghaeana dokdonensis strain DSW-6 was found to produce antibacterial agents, and the agents were then purified and analyzed by LC-MS/MS and 1D- and 2D-NMR spectrometries. The bioactive compounds were successfully identified as cholic acid and glycine-conjugated glycocholic acid, the $7{\alpha}$-dehydroxylated derivatives (deoxycholic acid and glycodeoxycholic acid) of which were also detected in relatively small amounts. Other marine isolates, taxonomically different from DSW-6, were also able to produce the compounds in a quite different production ratio from DSW-6. As far as we are aware of, these bile acids are produced by specific members of the genus Streptomyces and Myroides, and thought to be general secondary metabolites produced by a variety of bacterial taxa that are widely distributed in the sea.
Keywords
Cholic acid; glycocholic acid; bile acid; $7\alpha-dehydroxylation$;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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