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Nitrogen Control in Corynebacterium glutamicum: Proteins, Mechanisms, Signals  

Burkovski, Burkovski (Lehrstuhl fur Mikrobiologie, Friedrich-Alexander-Universital Erlangen-Nurnberg)
Andreas, Andreas (Lehrstuhl fur Mikrobiologie, Friedrich-Alexander-Universital Erlangen-Nurnberg)
Publication Information
Journal of Microbiology and Biotechnology / v.17, no.2, 2007 , pp. 187-194 More about this Journal
Abstract
In order to utilize different nitrogen sources and to survive in a situation of nitrogen limitation, microorganisms have developed sophisticated mechanisms to adapt their metabolism to a changing nitrogen supply. In this communication, the recent knowledge of nitrogen regulation in the amino acid producer Corynebacterium glutamicum is summarized. The core adaptations of C. glutamicum to nitrogen limitation on the level of transcription are controlled by the global regulator AmtR. Further components of the signal pathway are GlnK, a $P_{II}-type$ signal transduction protein, and GlnD. Mechanisms involved in nitrogen control in C. glutamicum regulating gene expression and protein activity are repression of transcription, protein-complex formation, protein modification by adenylylation, change of intracellular localization, and proteolysis.
Keywords
Ammonium; Corynebacterium; global regulation; nitrogen control; nitrogen metabolism; nitrogen regulation;
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