Influence of Agitation Intensity and Aeration Rate on Production of Antioxidative Exopolysaccharides from Submerged Mycelial Culture of Ganoderma resinaceum
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Kim Hyun-Mi
(Department of Biotechnology, Daegu University)
Kim Sang-Woo (Department of Biotechnology, Daegu University) Hwang Hye-Jin (Department of Biotechnology, Daegu University) Park Moon-Ki (Department of Bioenvironment Science, Daegu Haany University) Mahmoud Yehia A.-G. (Botany Department, Faculty of Sciences, Tanta University) Choi Jang-Won (Department of Bioindustry, Daegu University) Yun Jong-Won (Department of Biotechnology, Daegu University) |
1 | Aruoma, O. I. 1996. Characterization of drugs as antioxidant prophylactics. Free Radic. Biol. Med. 20: 675-705 DOI ScienceOn |
2 | Finkel, T. and N. J. Holbrook. 2000. Oxidants, oxidative stress and the biology of aging. Nature 408: 239-247 DOI ScienceOn |
3 | Guillouet, S., J. H. Choi, C.K. Rha, and A. J. Sinskey. 1999. Effect of yeast extract on the production and the quality of the polysaccharide, zooglan, produced by Zoogloea ramigera 115SLR. Appl. Microbiol. Biotechnol. 51: 235-240 DOI |
4 | Kim, H. H., J. G. Na, Y. K. Chang, G. T. Chun, S. J. Lee, and Y. H. Jeong. 2004. Optimization of submerged culture conditions for mycelial growth and exopolysaccharides production by Agaricus blazei. J. Microbiol. Biotechnol. 14: 944-951 |
5 | Lakshmi, B., T. A. Ajith, N. Sheena, N. Gunapalan, and K. K. Janardhanan. 2003. Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderrna lucidurn occurring in South India. Teratog. Carcinog. Mutagen. 23: 85-97 DOI ScienceOn |
6 | Liu, F., V. E. Ooi, and S. T. Chang. 1997. Free radical scavenging activities of mushroom polysaccharide extracts. Life Sci. 60: 763-771 DOI ScienceOn |
7 | Osaku, C. A., G. L. Sassaki, G. T. Zancan, and M. Iacomini. 2002. Study on neutral exopolysaccharides produced by the ectomycorrhiza Thelephora terrestis. FEMS Microbial. Lett. 216: 145-149 DOI |
8 | Packer, H. L. and C. R. Thomas. 1990. Morphological measurements on filamentous microorganisms by fully automatic image analysis. Biotechnol. Bioeng. 35: 870-881 DOI |
9 | Park, J. P., Y. M. Kim, S. W. Kim, H. J. Hwang, Y. J. Cho, Y. S. Lee, C. H. Song, and Y. W. Yun. 2002. Effect of aeration rate on the mycelial morphology and exo-biopolymer production in Cordyceps millitaris. Process. Biochem. 37: 1257-1262 DOI ScienceOn |
10 | Tang, Y. J. and J. J. Zhong. 2003. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme Microb. Technol. 32: 478-484 DOI ScienceOn |
11 | Wolfrom, M. L. and A. Thompson. 1963. Acetylation. Methods Carbohydr. Chem. 2: 211-215 |
12 | Yang, B. K., S. C. Jeong, and C. H. Song. 2002. Hypolipidemic effect of exo- and endo-polymer produced from submerged mycelial culture of Ganoderma lucidum. J. Microbiol. Biotechnol. 12: 872-877 과학기술학회마을 |
13 | Yang, B. K., H. J. Lee, S. C. Jeong, W. J. Lim, and C. H. Song. 2005. Hypoglycemic effect of Collybia corifluens exobiopolymer produced by submerged mycelial culture on diabetic rats. J. Microbiol. Biotechnol. 15: 136-140 과학기술학회마을 |
14 | Ames, B. N. 1983. Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative disease. Science 221: 1256-1264 DOI ScienceOn |
15 | Yang, F. C. and C. B. Liau. 1998. The influence of environmental conditions on polysaccharide formation by Ganoderma lucidum in submerged cultures. Process Biochem. 33: 547-553 DOI ScienceOn |
16 | Cui, Y. Q., R. G. J. M. van der Lans, and K. C. A. M. Luyben. 1997. Effect of agitation intensities on fungal morphology of submerged fermentation. Biotechnol. Bioeng. 55: 715-726 DOI ScienceOn |
17 | Yang, F. C. and C. B. Liau. 1998. Effects of cultivating conditions on the mycelial growth of Ganoderma lucidum in submerged flask cultures. Bioprocess Eng. 19: 233-236 |
18 | Choi, D. B., S. H. Kang, Y. H. Song, K. H. Kwun, K. J. Jeong, and W. S. Chao 2005. Exo-polysaccharide production in liquid culture of Pleurotusferulae. J. Microbiol. Biotechnol. 15: 368-375 과학기술학회마을 |
19 | Cui, Y. Q., R. G. J. M. van der Lans, and K. C. A. M. Luyben. 1998. Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation. Biotechnol. Bioeng. 57: 745-790 |
20 | Dubois, M., K. A. Gillis, J. K. Hamilton, P. A. Febers, and F. Smith. 1956. Colorimetric method for determination of sugar and related substances. Anal. Chem. 28: 350-356 DOI |
21 | Wolfrom, M. L. and A. Thompson. 1963. Reduction with sodium borohydride. Methods Carbohydr. Chem. 2: 65-67 |
22 | Chen, S. C., M. K. Lu, J. J. Cheng, and D. L. Wang. 2005. Antiangiogenic activities of polysaccharides isolated from medicinal fungi. FEMS Microbiol. Lett. 249: 247-254 DOI ScienceOn |
23 | Qin, C., K. Huang, and H. Xu. 2002. Protective effect of polysaccharide from the loach on the in vitro and in vivo peroxidative damage of hepatocyte. J. Nutr. Biochem. 13: 592-597 DOI ScienceOn |
24 | Kim, S. W., H. J. Hwang, J. W. Choi, and J. W. Yun. 2005. Characterization of exopolysaccharides produced by submerged culture of an enthomopathogenic fungus Paecilornyces sinclairii by using multi angle laser light scattering. J. Microbiol. Biotechnol. 15: 560-567 과학기술학회마을 |
25 | Martin, A. M. and V. I. Bailey. 1985. Growth of Agaricus carnpestris NRRL 2334 in the form of pellets. Appl. Environ. Microbiol. 49: 1502-1506 |
26 | Tsipali, E., S. Whaley, J. Kalbfleisch, H. E. Ensley, I. W. Browder, and D. L. Williams. 2001. Chemical characters and antioxidative properties of sulfated polysaccharides from Laminaria japonica. J. Appl. Phycol. 13: 67-70 DOI ScienceOn |
27 | Kim, H. O. and J. W. Yun. 2005. A comparative study on the production of exopolysaccharides between two entomopathogenic fungi Cordyceps militaris and Cordyceps sinensis in submerged mycelial cultures. J. Appl. Microbiol. 99: 728-738 DOI ScienceOn |
28 | Ng, T. B., F. Liu, and Z. T. Wang. 2000. Antioxidative activity of natural products from plants. Life Sci. 66: 709-723 DOI ScienceOn |
29 | Mizuno, T., G. Wang, J. Zhang, H. Kawagish, T. Nishitoba, and J. Li. 1955. Ganoderrna lucidurn and Ganoderrna tsugae: Bioactive substances and medicinal effects. Food Rev.Int. 11: 151-166 DOI ScienceOn |
30 | Wasser, S. P. 2002. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbial. Biotechnol. 60: 258-274 DOI |
31 | De Baets, S., S. Du Laing, C. Francois, and E. J. Vandamme. 2002. Optimization of exopolysaccharide production by Tremella mesenterica NRRL Y-6158 through implementation of fed-batch fermentation. J. Ind. Microbiol. Biotechnol. 29: 181-184 DOI ScienceOn |
32 | Halliwell, B., J. M. C. Gutteridge, and O.I. Aruoma. 1987. The deoxyribose method: A simple 'test-tube' assay for determination of rate constants for reactions of hydroxyl radicals. Anal. Chem. 165: 215-219 |
33 | Cao, Q. Z. and Z. B. Lin. 2004. Antitumor and antiangiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol. Sin. 25: 833-838 |
34 | Jeong, S. C., S. P. Cho, B. K. Yang, Y. T. Jeong, K. S. Ra, and C. H. Song. 2004. Immuno-modulating activity of the exo-polymer from submerged mycelial culture of Phellinus pini. J. Microbiol. Biotechnol. 14: 15-21 |
35 | Chu, Y. H., C. L. Chang, and H. F. Hsu. 2000. Flavonoid content of several vegetables and their antioxidant activity. J. Sci. Food Agric. 80: 561-566 DOI ScienceOn |
36 | Liu, F. and T. B. Ng. 2000. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci. 66: 725-735 DOI ScienceOn |
37 | Beauchamp, C. and I. Fridovich. 1971. Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44: 276-287 DOI ScienceOn |
38 | Papagianni, M. 2004. Fungal morphology and metabolite production in submerged mycelial processes. Biotechnol. Adv. 22: 189-259 DOI ScienceOn |
39 | Bae, J. T., G. S. Sim, D. H. Lee, B. C. Lee, H. B. Pyo, T. B. Choe, and J. W. Yun. 2005. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-l expression in ultraviolet A-irradiated human dermal fibroblasts. FEMS Microbiol. Left. 251:347-354 DOI ScienceOn |
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