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S-Adenosyl-L-Methionine Analogues to Enhance the Production of Actinorhodin  

Chong You-Hoon (Department of Molecular Biotechnology, Konkuk University)
Young Jung-Mo (Bio/Molecular Informatics Center, Konkuk University)
Kim Jin-Young (Department of BioMedical Science and Technology, Konkuk University)
Lee Yu-Kyung (Bio/Molecular Informatics Center, Konkuk University)
Park Kwang-Su (Department of Molecular Biotechnology, Konkuk University)
Cho Jun-Ho (Department of Molecular Biotechnology, Konkuk University)
Kwon Hyung-Jin (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University)
Suh Joo-WOn (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University)
Lim Yoong-Ho (Bio/Molecular Informatics Center, Konkuk University)
Publication Information
Journal of Microbiology and Biotechnology / v.16, no.7, 2006 , pp. 1154-1157 More about this Journal
Abstract
It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.
Keywords
Actinorhodin; Streptomyces coelicolor; S-adenosyl-$_L$-methionine; S-adenosyl-$_L$-homocysteine;
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