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Evaluation of Genotoxicity on Plant-Derived Dietary Sulfur  

Lee Yoon-Ik (Biosciences, CareMedix Ltd.)
Lee Young-Seok (Biosciences, CareMedix Ltd.)
Park Jong-Cheol (Biosciences, CareMedix Ltd.)
Lee Kwan-Bok (School of Bioscience and Biotechnology, Chungnam National University)
You Kwan-Hee (School of Bioscience and Biotechnology, Chungnam National University)
Publication Information
Journal of Microbiology and Biotechnology / v.16, no.5, 2006 , pp. 817-820 More about this Journal
Abstract
The potential genotoxicity of methylsulfonylmethane, a crystalline organic sulfur, derived from chemically modified lignin from plants was evaluated using in vitro and in vivo assays. In the bacterial reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, and TA1538, methylsulfonylmethane did not induce any significant increase of His' revertants. In the in vitro chromosome aberration test using Chinese Hamster Lung (CHL) cells, no aberration effects were seen. In the in vivo evaluation using a micronucleus test, negative results were obtained. Accordingly, the results indicated that methylsulfonylmethane is not genotoxic and its use is unlikely to present a potential hazard.
Keywords
Genotoxicity; dietary sulfur; lignin; micronucleus;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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