Assessment of the Human Risk by an Intake of Ethyl Carbamate Present in Major Korean Fermented Foods
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Noh, I-Woo
(Division of Bioscience and Biotechnology, Konkuk University)
Ha, Mi-Sun (Division of Bioscience and Biotechnology, Konkuk University) Han, Eun-Mee (Division of Bioscience and Biotechnology, Konkuk University) Jang, In-Sook (Division of Bioscience and Biotechnology, Konkuk University) An, Youn-Joo (Division of Bioscience and Biotechnology, Konkuk University) Ha, Sang-Do (Department of Environmental Science, Konkuk University) Park, Sang-Kyu (Department of Food Science & Technology, Chung-Ang University) Bae, Dong-Ho (Bio/Molecular Informatics Center, Konkuk University) |
1 | Aresta, M., M. Boscolo, and W. Franco. 2001. Copper (II) catalysis in cyanide conversion into ethyl carbamate in spirits and relevant reactions. J. Agric. Food Chem. 49: 2819-2824 DOI ScienceOn |
2 | Chung, H. J. and H. J. Kwon. 1997. Dependence of ethyl carbamate formation on the fermentation variables in Korean traditional soy sauce. Korean J. Soc. Food Sci. 13: 92-98 과학기술학회마을 |
3 | Conacher, H. B. S., B. D. Page, B. P. Y. Lau, J. F. Lawrence, R. Bailey, P. Calway, J. P. Hanchay, and B. Mori. 1987. Capillary column gas chromatographic determination of ethyl carbamate in alcoholic beverages with confirmation by gas chromatography/mass spectrometry. J. Ass. Offic. Anal. Chem. 70: 749-751 |
4 | Hasnip, S., A. Caputi, C. Crews, and P. Brereton. 2004. Effects of storage time and temperature on the concentration of ethyl carbamate and its precursors in wine. Food Addit. Contam. 21: 1155-1161 DOI ScienceOn |
5 | U.S. Department of Health and Human Services. 1993. Hazardous Substances Databank (HSDB, online database). National Toxicology Information Program, Washington, DC, U.S.A |
6 | U.S. Environmental Protection Agency. 1999. Integrated Risk Information System (IRIS) on Ethyl Carbamate. National Center for Environmental Assessment, Office of Research and Development, Washington, DC, U.S.A |
7 | Arena, M. E., M. C. Saguir, and M. Nadra. 1999. Arginine, citrulline and ornithine metabolism by lactic acid bacteria. Int. J. Food Microbiol. 52: 155-161 DOI ScienceOn |
8 | KHID. 2002. Korean Health and Nutrition Survey and the Report. Ministry of Health and Welfare, Gwacheon, Republic of Korea |
9 | Ha, M. S., K. S. Kwon, M. Kim, H. R. Park, S. J. Hu, H. Lee, K. M. Kim, E. J. Ko, S. D. Ha, and D. H. Bae. 2006. Exposure assessment of ethyl carbamate in alcoholic beverages. J. Microbiol. Biotechnol. 16: 480-483 과학기술학회마을 |
10 | Cha, S. W., H. J. Lee, M. H. Cho, M. H. Lee, W. S. Koh, S. S. Han, J. A. Kim, E. S. Lee, D. H. Nam, and T. C. Jeong. 2001. Role of corticosteron in ethyl carbamate-induced immunosuppression in female BALB/c mice. Toxicol. Lett. 119: 173-181 DOI ScienceOn |
11 | Battaglia, R., H. B. S. Conacher, and B. D. Page. 1990. Ethyl carbamate (urethane) in alcoholic beverages and foods. Food Addit. Contam. 4: 477-496 |
12 | Canas, B. J., D. C. Harvey, L. R. Robinson, M. P. Sullivan, F. L. Joe, and G. W. Diachenko. 1989. Ethyl carbamate levels in selected foods and beverages. J. Ass. Offic. Anal. Chem. 72: 873-876 |
13 | Ough, C. S. 1976. Ethyl carbamate in fermented beverages and food. Naturally occuring ethyl carbamate. J. Agric. Food Chem. 24: 323-328 DOI |
14 | Shon, Y. H. and K. S. Nam. 2005. Induction of phase enzymes and inhibition of cytochrome p450 isoenzymes by chitosanoligosaccharides. J. Microbiol. Biotechnol. 15: 183- 187 과학기술학회마을 |
15 | Tomisawa, M., H. Suemizu, Y. Ohnishi, C. Maruyama, K. Urano, T. Usui, K. Yasuhara, N. Tamaoki, and K. Mitsumori. 2003. Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice. Toxicol. Lett. 142: 111-117 DOI ScienceOn |
16 |
Xin, O. Z., K. H. Park, Y. Y. Jin, I. H. Lee, Y. Y. Yang, and J. W. Suh. 2005. Isolation and characterization of a new |
17 | Hoffler, U., D. Dixon, S. Peddada, and B. I. Ghanayem. 2005. Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice. Mutat. Res. 572: 58-72 DOI ScienceOn |
18 | Lee, S. K., C. Y. Choi, J. S. Ahn, J. Y. Cho, C. S. Park, and Y. J. Yoon. 2004. Identification of a cytochrome P450 hydroxylase gene involved in rifamycin biosynthesis by Amycolatopsis mediterranei S699. J. Microbiol. Biotechnol. 14: 356-362 |
19 | Ma, Y. P., F. Q. Deng, D. Z. Chen, and S. W. Sun. 1995. Determination of ethyl carbamate in alcoholic beverages by capillary multi-dimensional gas chromatography with thermionic specific detection. J. Chromatogr. A 695: 259- 265 DOI ScienceOn |
20 | Matsudo, T., K. Aoki, N. Fokuta, M. Sasaki, and K. Uchida. 1993. Determination of ethyl carbamate in soy sauce and its possible precursor. J. Agric. Food Chem. 41: 352-356 DOI ScienceOn |
21 | Lachenmeier, D. W., W. Frank, and T. Kuballa. 2004. Application of tandem mass spectrometry combined with gas chromatography to the routine analysis of ethyl carbamate in stone-fruit spirits. Rapid Commun. Mass. Spec. 19: 108- 112 DOI |
22 | KRISS. Korean standard body. Korean Research Institute of Standards and Science. Daejeon, Korea, 2000 |
23 | Mira de Orduna, R., S. Q. Liu, M. L. Patchett, and G. J. Pilone. 2000. Ethyl carbamate precursor citrulline formation from arginine degradation by malolactic wine lactic acid bacteria. FEMS Microbiol. Lett. 183: 31-35 DOI |
24 | Ough, C. S. 1976. Ethyl carbamate in fermented beverages and foods. II. Possible formation of ethyl carbamate from diethyl dicarbonate addition to wine. J. Agric. Food Chem. 24: 328-331 DOI |
25 | IARC. 1974. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man. Int. Agency Res. Cancer 7: 111 |
26 | Benson, R. W. and F. A. Bleand. 1997. Modulation of urethane (ethyl carbamate) carcinogenicity by ethyl alcohol: A review. Int. J. Toxicol. 16: 521-544 DOI |
27 | Lachenmeier, D.W. 2005. Rapid screening for ethyl carbamate in stone-fruit spirits using FTIR spectroscopy and chemometrics. Anal. Bioanal. Chem. 382: 1407-1412 DOI |
28 | Schlatter, J. and W. K. Lutz. 1990. The carcinogenic potential of ethyl carbamate (urethane): Risk assessment at human dietary exposure levels. Food Chem. Toxicol. 28: 205-211 DOI ScienceOn |
29 | Hasegawa, Y., T. Nakamura, Y. Tonogai, S. Terasawa, Y. Ito, and M. Chiyama. 1990. Determination of ethyl carbamate in various fermented foods by selected ion monitoring. J. Food Prot. 53: 1058-1061 DOI |
30 | Tonon, T. and A. Lonvaud-Funel. 2002. Arginine metabolism by wine Lactobacilli isolated from wine. Food Microbiol. 19: 451-461 DOI ScienceOn |
31 | Kim, Y. K. L., E. Koh, H. J. Chung, and H. Kwon. 2000. Determination of ethyl carbamate in some fermented Korean foods and beverages. Food Addit. Contam. 17: 469-475 DOI |
32 | Hoffler, U., H. A. El-Masri, and B. I. Ghanayem. 2003. Cytochrome P450 2E1 (CYP2E1) is the principle enzyme responsible for urethane metabolism: Comparative studies using CYP2E1-null and wild-type mice. J. Pharmacol. Exp. Ther. 305: 557-564 DOI |
33 | Koh, E. M. and H. J. Kwon. 1996. Determination of fermentation specific carcinogen, ethyl carbamate, in kimchi. Korean J. Food Sci. Technol. 28: 421-429 과학기술학회마을 |
34 | Beland, F. A., R. W. Benson, P. W. Mellick, R. M. Kobatch, D. W. Roberts, J. I. Fang, and D. R. Doerge. 2004. Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F mice. Food Chem. Toxicol. 43: 1-19 |
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