Analysis of Influence of Environmental Conditions on Ganoderic Acid Content: in Ganoderma lucidum Using Orthogonal Design |
Li Na
(Microbiology Department, College of Life Sciences Nanjing Agricultural University)
Liu Xiao Hua (Microbiology Department, College of Life Sciences Nanjing Agricultural University) Zhou Jie (Microbiology Department, College of Life Sciences Nanjing Agricultural University) Li Yu Xiang (Microbiology Department, College of Life Sciences Nanjing Agricultural University) Zhao Ming Wen (Microbiology Department, College of Life Sciences Nanjing Agricultural University) |
1 | Charonnet, C. O., C. E. Sams, and W. S. Conway. 1999. Calcium effect on the mycelial cell walls of Botrytis cinerea. Phytochemistry 52: 967-976 DOI ScienceOn |
2 | Fang, Q. H. and J. J. Zhong. 2002. Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of Ganoderma lucidum. Process Biochem. 37: 769-774 DOI ScienceOn |
3 | Fang, Q. H. and J. J. Zhong. 2002. Submerged fermentation of higher fungus Ganoderma lucidum for production of valuable bioactive metabolites -- ganoderic acid and polysaccharide. Biochem. Eng. J. 10: 61-65 DOI ScienceOn |
4 | Gai, J. Y. 2000. Methods of Experimental Statistics, pp. 99- 109. 3rd Ed. Agricultural Press of China (in Chinese) |
5 | Guo, C. Y. 1998. Review of pharmacological research of Ganoderma lucidum. Edible Fungi China (in Chinese). 17: 34-35 |
6 | Joo, J. H., J. M. Lim, H. O. Kim, S. W. Kim, H. J. Hwang, J. W. Choi, and J. W. Yun. 2004. Optimization of submerged culture conditions for exopolysaccharide production in Sarcodon aspratus (Berk) S.Ito TG-3. World J. Microbiol. Biotechnol. 20: 763-773 |
7 | Zhao, M. W., J. Y. Zhong, W. Q. Liang, N. Wang, M. J. Chen, D. B. Zhang, Y. J. Pan, and S. C. Jong. 2004. Analysis of squalene synthase expression during the development of Ganoderma lucidum. J. Microbiol. Biotechnol. 14: 116- 120 |
8 | Mizuno, T., G. Wang, J. Zhang, H. Kawagishi, T. Nishitoba, and J. Reishi. 1995. Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects. Food Rev. Int. 11: 151-166 DOI ScienceOn |
9 | Lee, M. T., W. C. Chen, and C. C. Chou. 1997. Medium improvement by orthogonal array designs for cholesterol oxidase production by Rhodococcus equi No. 23. Process Biochem. 32: 697-703 DOI ScienceOn |
10 | Shiao, M. S., K. R. Lee, J. L. Lee, and T. W. Cheng. 1994. Natural products and biological activities of the Chinese medicinal fungus Ganoderma lucidum. Food Phytochemicals for Cancer Prevention II; ACS Symposium Series. American Chemical Society, Washington, DC 547: 342-354 |
11 | Zhao, M. W., J. Y. Zhong, N. Wang, W. Q. Liang, and Y. J. Pan. 2003. Research progress on the squalene synthase. Acta Microbiol. Sin. (in Chinese) 43: 676-680 |
12 | Jolidon, S., A. M. Polak, P. Guerry, and P. G. Hartman. 1990. Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agent. Biochem. Soc. Trans. 18: 47-48 DOI |
13 | Lim, J. M., S. W. Kim, H. J. Hwang, J. H. Joo, H. O. Kim, J. W. Choi, and J. W. Yun. 2004. Optimization of medium by orthogonal matrix method for submerged mycelial culture and exopolysaccharide production in Collybia maculate. Appl. Biochem. Biotechnol. 119: 159-170 DOI ScienceOn |
14 | Tang, Y. J. and J. J. Zhong. 2003. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme Microb. Technol. 32: 478-484 DOI ScienceOn |
15 | Zhang, D. L, S. M. Jennings, G. W. Robinson, and D. Poulter. 1993. Yeast squalene synthase: Expression, purification, and characterization of soluble recombinant enzyme. Arch. Biochem. Biophys. 304: 133-143 DOI ScienceOn |
16 | Xu, C. P., S. W. Kim, H. J. Hwang, J. W. Choi, and J. W. Yun. 2003. Optimization of submerged culture conditions for mycelial growth and exo-biopolymer production by Paecilomyces tenuipes C240. Process Biochem. 38: 1025- 1030 DOI ScienceOn |
17 | Tang, Y. J. and J. J. Zhong. 2002. Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzyme Microb. Technol. 31: 20-28 DOI ScienceOn |
18 | Ding, F. P., H. Noritomi, and K. Nagahama. 2001. Optimization of fermentation conditions for preparation of polygalacturonic acid transeliminase by Erwinia carotovora IFO3830. Biotechnol. Prog. 17: 311-317 DOI ScienceOn |
19 | Jong, S. C. and J. M. Birmingham. 1992. Medicinal benefits of the mushroom Ganoderma lucidum. Adv. Appl. Microbiol. 37: 101-134 DOI |
20 | Tang, Y. J. and J. J. Zhong. 2003. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnol. Prog . 19: 1842-1846 DOI ScienceOn |
21 | Tsujikura, Y., T. Higuchi, Y. Miyamoto, and S. Sato. 1992. Manufacture of ganoderic acid by fermentation of Ganoderma lucidum. Jpn. Kokai Tokkyo Koho JP 04304890 (in Japanese) |
22 | Kohda, H., W. Tokumoto, K. Sakamoto, M. Fujii, Y. Hirai, and K. Yamasaki. 1985. The biologically active constituents of Ganoderma lucidum (Fr.) Karst. histamine releaseinhibitory triterpenes. Chem. Pharm. Bull. 33: 1367-1374 DOI ScienceOn |
23 | Cheng, R. Y. and D. Q. Yu. 1990. Research progress on the chemical component of Ganoderma lucidum triterpenoid. Acta Pharmaceut. Sin. (in Chinese) 25: 940-953 |
24 | Tai, S. C., W. Y. Sun, and J. J. He. 2005. Applied Statistical Analysis, pp. 204-229. 2th Ed. Wuhan University Press (in Chinese) |
25 | Fang, Q. H. and J. J. Zhong. 2002. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnol. Prog. 15: 51-54 |
26 | Tang, Y. J. and J. J. Zhong. 2004. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of the medicinal mushroom Ganoderma lucidum. Biochem. Eng. J. 21: 259-264 DOI ScienceOn |
27 | Fang, Q. H., Y. J. Tang, and J. J. Zhong. 2002. Significance of inoculation density control in production of polysaccharide and ganoderic acid by submerged culture of Ganoderma lucidum. Process Biochem. 37: 1375-1379 DOI ScienceOn |
28 | Kim, H. O., J. M. Lim, J. H. Joo, S. W. Kim, H. J. Hwang, J. W. Choi, and J. W. Yun. 2005. Optimization of submerged culture condition for the production of mycelial biomass and exopolysaccharides by Agrocybe cylindracea. Bioresour. Technol. 96: 1175-1182 DOI ScienceOn |