Effects of Dissolved Oxygen Level on Avermectin Production by Streptomyces avermitilis in Computer-Controlled Bioreactor Cultures |
Song, Sung-Ki
(Department of Molecular Bioscience, Kangwon National University)
Jeong, Yong-Seob (Faculty of Biotechnology, Chonbuk National University) Kim, Pyeung-Hyeun (Department of Molecular Bioscience, Kangwon National University) Chun, Gie-Taek (Department of Molecular Bioscience, Kangwon National University) |
1 | Brunker, P., W. Minas, P. T. Kallio, and J. E. Bailey. 1998. Genetic engineering of an industrial strain of Saccaropolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (VHb). Microbiology 144: 2441-2448 DOI ScienceOn |
2 | Dick, O., U. Onken, I. Sattler, and A. Zeeck. 1994. Influence of increased dissolved oxygen concentration on productivity and selectivity in cultures of a colabomycin-producing strain of Streptomyces griseoflavus. Appl. Microbiol. Biotechnol. 41: 373-377 |
3 | Hilgendorf, P., V. Heiser, H. Diekmann, and M. Thoma. 1987. Constant dissolved oxygen concentrations in cephalosporin C fermentation: Applicability of different controllers and effect on fermentation parameters. Appl. Microbiol. Biotechnol. 27: 247-251 |
4 | Justen, P., G. C. Paul, A. W. Nienow, and C. R. Thomas. 1996. Dependence of mycelial morphology on impeller type and agitation intensity. Biotechnol. Bioeng. 52: 672-684 DOI ScienceOn |
5 | Kim, C. Y., H. J. Park, Y. J. Yoon, H. Y. Kang, and E. S. Kim. 2004. Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2. J. Microbiol. Biotechnol. 14: 1089-1092 |
6 | Kohler, P. 2001. The biochemical basis of anthelmintic action and resistance. Int. J. Parasitol. 31: 336-345 DOI ScienceOn |
7 | Robin, J., S. Bonneau, D. Schipper, H. Noorman, and J. Nielsen. 2003. Influence of the adipate and dissolved oxygen concentrations on the -lactam production during continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus. Metab. Eng. 5: 42-48 DOI ScienceOn |
8 | Rollins, M. J., S. E. Jensen, and D. W. S. Westlake. 1988. Effect of aeration on antibiotic production by Streptomyces clavuligerus. J. Ind. Microbiol. 3: 357-364 DOI |
9 | Roubos, J. A., P. Krabben, R. G. M. Luiten, H. B. Verbruggen, and J. J. Heijnen. 2001. A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus. Biotechnol. Prog. 17: 336-347 DOI ScienceOn |
10 | van Sujidam, J. C. and B. Metz. 1981. Influence of engineering variables upon the morphology of filamentous molds. Biotechnol. Bioeng. 23: 111-148 DOI |
11 | Yoon, Y. J., E. S. Kim, Y. S. Hwang, and C. Y. Choi. 2004. Avermectin: Biochemical and molecular basis of its biosynthesis and regulation. Appl. Microbiol. Biotechnol. 63: 626-634 DOI |
12 | Ikeda, H., T. Nonomiya, and S. Omura. 2001. Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: Analysis of enzymatic domains in four polyketide synthases. J. Ind. Microbiol. Biotechnol. 27: 170-176 DOI |
13 | Chen, S. T., O. D. Hensens, and M. D. Schulman. 1989. Biosynthesis, pp. 55-72. In W. C. Campbell (ed.), Ivermectin and Abamectin. Springer-Verlag, New York |
14 | Magnolo, S. K., D. L. Leenutaphong, J. A. DeModena, J. E. Curtis, J. E. Bailey, J. L. Galazzo, and D. E. Hughes. 1991. Actinorhodin production by Streptomyces coelicolor and growth of Streptomyces lividans are improved by the expression of a bacterial hemoglobin. Biotechnology (NY) 9: 173-176 DOI ScienceOn |
15 | Gbewonyo, K., D. Dimasi, and B. C. Buckland. 1987. Characterization of oxygen transfer and power absorption of hydrofoil impellers in viscous mycelial fermentations, pp. 128-234. In C. S. Ho and J. Y. Oldshue (eds.), Biotechnology Processes Scale-Up and Mixing. American Institute of Chemical Engineers, New York |
16 | Pfefferle, C., U. Theobald, H. Gurtler, and H. P. Fiedler. 2000. Improved secondary metabolite production in the genus Streptosporangium by optimization of the fermentation conditions. J. Biotechnol. 80: 135-142 DOI ScienceOn |
17 | Rollins, M. J., S. E. Jensen, and D. W. S. Westlake. 1989. Regulation of antibiotic production by iron and oxygen during defined medium fermentations of Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 31: 390-396 |
18 | Malik, V. S. 1980. Microbial secondary metabolism. Trends. Biochem. Sci. 5: 68-72 DOI ScienceOn |
19 | Campbell, W. C., M. H. Fisher, E. O. Stapley, G. Albers-Schonberg, and T. A. Jacob. 1983. Ivermectin: A potent new antiparasitic agent. Science 221: 823-828 DOI |
20 | DeTilly, G., D. G. Mou, and C. L. Cooney. 1983. Optimization and economics of antibiotic production, pp. 190-209. In J. E. Smith, D. R. Berry, and B. Kristiansen (eds.), The Filamentous Fungi, vol. 4. Edward Arnold, London |
21 | Kaiser, D., U. Onken, I. Sattler, and A. Zeeck. 1994. Influence of increased dissolved oxygen concentration on the formation of secondary metabolites by manumycin-producing Streptomyces parvulus. Appl. Microbiol. Biotechnol. 41: 309-312 DOI |
22 | Park, H. S., S. H. Kang, H. J. Park, and E. S. Kim. 2005. Doxorubicin productivity improvement by the recombinant Streptomyces peucetius with high-copy regulatory genes cultured in the optimized media composition. J. Microbiol. Biotechnol. 15: 66-71 과학기술학회마을 |
23 | Yegneswaran, P. K. and M. R. Gray. 1988. Effect of reduced oxygen on growth and antibiotic production in Streptomyces clavuligerus. Biotechnol. Lett. 10: 479-484 DOI |
24 | Enfors, S. O. and B. Mattiasson. 1983. Oxygenation of processes involving immobilized cells, pp. 41-60. In B. Mattiasson (ed.), Immobilized Cells and Organelles, vol. 2. CRC Press, Boca Raton, FL |
25 | Steel, M. R. and W. E. Maxon. 1966. Dissolved oxygen measurements in pilot- and production-scale novobiocin fermentations. Biotechnol. Bioeng. 8: 97-108 DOI |
26 | Song, S. K., Y. S. Jeong, and G. T. Chun. 2005. Development of avermectin high-yielding mutants through rational screening strategy based on understanding of biosynthetic pathway of avermectin . Korean J. Biotechnol. Bioeng. 20: 471-477 |
27 | Taguchi, H., T. Yoshida, Y. Tomita, and S. Teramoto. 1968. The effects of agitation on disruption of the mycelial pellets in stirred fermentors. J. Ferment. Technol. 10: 814-822 |
28 | Doran, P. M. 1997. Bioprocess Engineering Principles, pp. 190-217. Academic Press, London |