Chloramphenicol Arrests Transition of Cell Cycle and Induces Apoptotic Cell Death in Myelogenous Leukemia Cells
![]() |
KANG KI YOUNG
(Department of Anatomy, Seonam University College of Medicine)
CHOI CHUL HEE (Department of Microbiology and Institute of Infectious Diseases, Kyungpook National University School of Medicine) OH JAE YOUNG (Department of Microbiology and Institute of Infectious Diseases, Kyungpook National University School of Medicine) KIM HYUN (Department of Anatomy, Kosin University College of Medicine) KWEON GI RYANG (Department of Biochemistry, Seonam University College of Medicine) LEE JE CHUL (Department of Microbiology and Institute of Infectious Diseases, Kyungpook National University School of Medicine) |
1 | Gong, J., F. Traganos, and Z. Darzynkiewicz. 1994. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 218: 314-319 DOI ScienceOn |
2 | Harbour, J. W. and D. C. Dean. 2000. Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2: E65-67 DOI ScienceOn |
3 | Kim, N. S., K. H. Chang, B. S. Chung, S. H. Kim, J. H. Kim, and G. M. Lee. 2003. Characterization of humanized antibody produced by apoptosis-resistant CHO cells under sodium butyrate-induced condition. J. Microbiol. Biotechnol. 13: 926-936 |
4 | Lim, H., M. K. Kim, Y.-H. Cho, J. M. Kim, Y. Lim, and C.-H. Lee. 2004. Inhibition of cell cycle progression and induction of apoptosis in HeLa cells by HY558-1, a novel CDK inhibitor isolated from Penicillium minioluteum F558. J. Microbiol. Biotechnol. 14: 978-984 |
5 | Miller, A. M. and A. A. Yunis. 1982. Nitroso-chloramphenicol: Cell cycle specificity of action. Pharmacology 24: 61-66 DOI ScienceOn |
6 | Ohtsubo, M., A. M. Theodoras, J. Schumacher, J. M. Roberts, and M. Pagano. 1995. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15: 2612-2624 DOI |
7 | Yunis, A. A. 1989. Chloramphenicol toxicity: 25 years of research. Am. J. Med. 87: 44N-48N |
8 |
Yunis, A. A., A. M. Miller, Z. Salem, and G. K. Arimura. 1980. Chloramphenicol toxicity: Pathogenetic mechanisms and the role of the p- |
9 | Nurse, P. 1994. Ordering of S phase and M phase in the cell cycle. Cell 79: 547-550 DOI PUBMED ScienceOn |
10 | Firkin, F. C. and A. W. Linnane. 1968. Differential effects of chloramphenicol on the growth and respiration of mammalian cells. Biochem. Biophys. Res. Commun. 32: 398-402 DOI ScienceOn |
11 | Ohtsubo, M. and J. M. Roberts. 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908-1912 DOI PUBMED |
12 | Leiter, L. M., H. S. Thatte, C. Okafor, P. W. Marks, D. E. Golan, and K. R. Bridges. 1999. Chloramphenico]-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions. J. Cell. Physiol. 180: 334-344 DOI ScienceOn |
13 | Hartwell, L. H. and T. A. Weinert. 1989. Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629-634 DOI PUBMED |
14 | Yao, J. D. C. and R. C. Moellering, Jr. 1999. Antibacterial agents, pp. 1474-1504. In P. R. Murray, E. J. Baron, M. A. Pfaller, F. C. Tenover, and R. H. Yolken (eds.). Manual of Clinical Microbiology. 7th ed. American Society for Microbiology, Washington DC, U.S.A |
15 | Robbana-Barnat, S., F. Dec]oitre, C. Frayssinet, J. M. Seigneurin, L. Toucas, and C. Lafarge-Frayssinet. 1997. Use of human lymphoblastoid cells to detect the toxic effect of chloramphenicol and metabolites possibly involved in aplastic anemia in man. Drug Chem. Toxicol. 20: 239-253 DOI ScienceOn |
16 | Salem, Z., T. Murray, and A. A. Yunis. 1981. The nitroreduction of chloramphenicol by human liver tissue. J. Lab. Clin. Med. 97: 881-886 |
17 | Guimaraes, C. A. and R. Linden. 2000. Chloramphenicol induces apoptosis in the developing brain. Neuropharmacol. 39: 1673-1679 DOI ScienceOn |
18 | Murray, T. R., K. M. Downey, and A. A. Yunis. 1983. Chloramphenicol-mediated DNA damage and its possible role in the inhibitory effects of chloramphenicol on DNA synthesis. J. Lab. Clin. Med. 102: 926-932 |
19 | Kato, J., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase cdk4. Genes Dev. 7: 331-342 DOI ScienceOn |
20 | Kim, M. K., Y.-H. Cho, J. M. Kim, M. W. Chun, S. K. Lee, Y. Lim, and C.-H. Lee. 2003. Inhibition of cell-cycle progression in human promyelocytic leukemia HL-60 cells by MCS-C2, novel cyclin-dependent kinase inhibitor. J. Microbiol. Biotechnol. 13: 607-612 |
21 | Lafarge-Frayssinet, C., S. Robbana-Barnat, C. Frayssinet, L. Toucas, and F. Decloitre. 1994. Cytotoxicity and DNA damaging potency of chloramphenicol and six metabolites: A new evaluation in human lymphocytes and Raji cells. Mutat. Res. 320: 207-215 DOI ScienceOn |
22 | Cardoso, M. C., H. Leonhardt, and B. Nadal-Ginard. 1993. Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74: 979-992 DOI ScienceOn |
23 | Goh, K. 1979. Chloramphenicol and chromosomal morphology. J. Med. 10: 159-166 |
24 | Abou-Khalil, S., W. H. Abou-Khalil, and A. A. Yunis. 1980. Differential effects of chloramphenicol and its nitroso analogue on protein synthesis and oxidative phosphorylation in rat liver mitochondria. Biochem. Pharmacol. 29: 2605-2609 DOI ScienceOn |
25 | Kapnusnik-Uner, J. E., M. A. Sande, and H. F. Chambers. 1996. Antimicrobial agents: Tetracycline, chloramphenicol, erythromycin, and miscellaneous antibacterial agents, pp. 1123-1154. In J. G. Hardman, L. E. Limbrid, P. B. Molinoff, R. W. Roddon, and A. G. Gilman (eds.). Goodman & Gilman's The Pharmacological Basis of Therapeutics. 9th ed. McGraw-Hill, New York, U.S.A |
26 | Yunis, A. A., G. K. Arimura, and M. Isildar. 1987. DNA damage induced by chloramphenicol and its nitroso derivative: Damage in intact cells. Am. J. Hematol. 24: 77-84 DOI ScienceOn |
27 | Yunis, A. A. 1973. Chloramphenicol-induced bone marrow suppression. Semin. Hematol. 10: 225-234 |
28 | Marks, M. I. and C. Laferriere. 1982. Chloramphenicol: Recent developments and clinical indications. Clin. Pharm. 1: 315-320 |
29 | Jeong, Y. W., K. S. Kim, J. Y Oh, J. C. Park, J. H. Bang, S. W. Choi, and J. C. Lee. 2003. Growth inhibition and apoptosis induction of gastric cancer cells by copper (II) glycinate complex. J. Microbiol. Biotechnol. 13: 394-399 |
30 | Holt, D. E., T. A. Ryder, A. Fairbairn, R. Hurley, and D. Harvey. 1997. The myelotoxicity of chloramphenicol: In vitro and in vivo studies: I. In vitro effects on cells in culture. Hum. Exp. Toxicol. 16: 570-576 DOI ScienceOn |
![]() |