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Lysophosphatidylcholine Suppresses the Expression of Phr1p and Pra1p, Surface Proteins Involved in the Morphogenesis of Candida albicans  

Shin, Duck-Hyang (Department of Life Science, College of Natural Sciences, Ewha Women University)
Choi, Won-Young (Department of Life Science, College of Natural Sciences, Ewha Women University)
Yoo, Yung-Joon (Department of Life Science, Kwangju Institute of Science and Technology (K-JIST))
Kim, Min-Kyoung (Department of Life Science, College of Natural Sciences, Ewha Women University)
Choi, Won-Ja (Department of Life Science, College of Natural Sciences, Ewha Women University)
Publication Information
Journal of Microbiology and Biotechnology / v.14, no.4, 2004 , pp. 868-871 More about this Journal
Abstract
Candida albicans has become the most important human pathogen in immunocompromised patients. One important feature of the pathogenicity in C. albicans is the morphological transition from yeast to hyphae. Previously, we reported that lysophosphatidylcholine (Lyso-PC) suppressed the hyphal transition through the MAP kinase pathway (Min et al., 2001). Therefore, it should be useful to examine the unknown genes involved in the MAP kinase pathway. As a way to identify target genes of Lyso-PC in hyphal suppression, this present study exploited two-dimensional electrophoresis. It was revealed that Lyso-PC suppressed expression of Phr1p and Pra1p, surface proteins involved in the morphogenesis.
Keywords
Candida albicans; two-dimensional electrophoresis; morphological transition; hyphal suppression; lysophosphatidyl-choline; PHR1; PRA1;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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