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Anticarcinogenic and Antigenotoxic Effects of Bacillus polyfermenticus  

Park, Eun-Ju (Division of Life Sciences, Kyungnam University)
Kim, Kee-Tae (Proco Biotech Co.)
Kim, Cheon-Jei (Division of Animal Life Science, Konkuk University)
Kim, Chang-Han (Division of Animal Life Science, Konkuk University)
Paik, Hyun-Dong (Division of Animal Life Science, Konkuk University)
Publication Information
Journal of Microbiology and Biotechnology / v.14, no.4, 2004 , pp. 852-858 More about this Journal
Abstract
The morbidity and mortality of colon cancer are increasing, because of the westernization of food habit. Probiotics such as lactic acid bacteria (LAB) have been known to play an important role in retarding colon carcinogenesis by possibly influencing metabolic, immunologic, and protective functions in the colon. In this study, we evaluated the effect of B. polyfermenticus SCD on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induced DNA damage in CHO-K, cells and human lymphocytes, and on proliferation of human colon cancer cell. Using the Comet assay to detect DNA damage, we found that B. polyfermenticus SCD protected cells from the DNA damage induced by MNNG in $CHO-K_1$ cells and in human lymphocytes. B. polyfermenticus SCD was also found to inhibit the growth of colon cancer cells in a dose-dependent manner, detected by the MTT assay. These results indicate that B. polyfermenticus SCD has the potential to inhibit not only DNA damage induced by a carcinogen, but also the proliferation of colon cancer cells.
Keywords
Bacillus polyfermenticus SCD; DNA damage; comet assay; colon cancer; MTT assay; antigenotoxic; anticarcinogenic;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 10  (Related Records In Web of Science)
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