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Antimicrobial Activity of Hetero-Chitosans and Their Oligosaccharides with Different Molecular Weights  

Park, Pyo-Jam (Department of Chemistry, Pukyong National University)
Je, Jae-Young (Department of Chemistry, Pukyong National University)
Byun, Hee-Guk (Department of Chemistry, Pukyong National University)
Moon, Sung-Hoon (Department of Chemistry, Pukyong National University)
Kim, Se-Kwon (Department of Chemistry, Pukyong National University)
Publication Information
Journal of Microbiology and Biotechnology / v.14, no.2, 2004 , pp. 317-323 More about this Journal
Abstract
This study was performed to investigate the antimicrobial effects of hetero-chitosans and their oligosaccharides against three Gram-negative bacteria and five Gram-positive bacteria. Nine classes of hetero-chitosan oligosaccharides consisted of partially deacetylated chitosans; 90％, 75％, and 50％ deacetylated chitosans. Based on molecular weight, they were prepared using an ultrafiltration membrane reactor system. Seventy-five percent deacetylated chitosan showed the highest antimicrobial acitivity as compared with the 90％ and 50％ deacetylated chitosan, and the activity was dependent on their molecular weights. It was apparent that the growth of Gram-negative bacteria is less inhibited in the presence of the heterochitosans and their oligosaccharides than Gram-positive bacteria. These results revealed that the antimicrobial effects of hetero-chitosans and their oligosaccharides depend on the degree of deacetylation, and their molecular weights.
Keywords
Hetero-chitosan; chitooligosaccharide; antimicrobial activity; minimum inhibitory concentration;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 47  (Related Records In Web of Science)
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