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Assessment of Reproductive Health Risk of Polychlorinated Biphenyls by Monitoring the Expression of Claudius and Transepithelial Electrical Resistance in Mouse Sertoli Cells  

Gye, Myung-Chan (Department of Life Science, College of Natural Sciences, Hanyang University)
Seiichiroh Ohsako (Molecular and Cellular Toxicology Section, National Institute for Environmental Studies)
Lee, Ho-Joon (Department of Physiology, Eulji University School of Medicine)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.4, 2003 , pp. 495-500 More about this Journal
Abstract
Tight junctions (TJ) between adjacent Sertoli cells in testis are important for the formation of the blood testis barrier (BTB). In an effort to verify the reproductive health risk of endocrine-active chemicals (EACs), changes in the transepithelial electrical resistance (TER) and the expression of TJ genes were examined by co-planar polychlorinated biphenyl (PCB) treatment in cultured mouse Sertoli cells. Although the increase in TER of Sertoli cells was accelerated by 10 nM co-planar PCB, it was downregulated by 100 nM co-planar PCB. The expression of claudin-1 was downregulated by co-planar PCB in a concentration-dependent manner. On the contrary, the expression of claudin-1 was increased in the Sertoli cells by 10 nM co-planar PCB treatment. These results suggest that the structure and function of TJ may be targeted by co-planar PCB in Sertoli cells. Assessment of the structure and function of TJ in Sertoli cells might be useful for screening the reproductive health risk of EACs.
Keywords
Tight junction; transepithelial electrical resistance; Sertoli cells; PCB;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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[ Suzaki,K.;Y.Kokai;N.Sawada;R.Takakuwa;K.Kuwahara;E.Isogai;H.Isogai;M.Mori ] / Virchows Arch.   DOI   ScienceOn
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[ Gregory,M.;J.Dufresne;L.Hermo;D.Cyr ] / Endocrinology   DOI   ScienceOn
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[ Turner,J.R.;J.M.Angle;E.D.Black;J.L.Joyal;D.B.Sacks;J.L.Madara ] / Am. J. Physoil
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[ Loertscher,J.A.;T.M.Lin;R.E.Peterson;B.L.Allen-Hoffmann ] / Toxicol Sci.   DOI   ScienceOn
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[ Bronstein,J.M.;K.Chen;S. Tiwari-Woodruff;H.I.Kornblum ] / J. Neurosci. Res.   DOI   ScienceOn
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[ Kato,Y.;K.Kenne;K.Haraguchi;Y.Masuda;R.Kimura;L.Warngard ] / Arch. Toxicol   DOI   ScienceOn
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[ Duffy,H.S.;G.R.John;S.C.Lee;C.F.Brosnan;D.C.Spray ] / J. Neurosci.
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[ Yoon,K.;L.Pallaroni;M.Stoner;K.Gaido;S.Safe ] / J. Steroid Biochem. Mol Biol.   DOI   ScienceOn
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[ Kannan,K.;D.L.Villeneuve;A.L.Blankenship;J.P.Giesy ] / J. Toxicol Environ Health A   DOI
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[ Saitou,M.;Y.Ando-Akatsuka;M.Itoh,M.Furuse;J.Inazawa;K.Fujimoto;S.Tsukita ] / Eur. J. Cell Biol.
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[ Kolluri,S.K.;C.Weiss;A.Koff;M.Gottlicher ] / Genes Dev.   DOI   ScienceOn
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[ Cyr,D.G.;L.Hermo;N.Egenberger;C.Mertineit;J.M.Trasler;D.W.Laird ] / Endocrinology   DOI   ScienceOn
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[ Kang,K.S.;M.R.Wilson;T.Hayashi;C.C.Chang;J.E.Trosko ] / Environ. Health Perspect   DOI   ScienceOn
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[ Ohmura,K.;N.Kohno;Y.Kobayashi;K.Yamagata;S.Sato;S.Kashiwabara;T.Baba ] / J. Biol. Chem.   DOI
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[ Morita,K.;M.Furuse;K.Fujimoto;S.Tsukita ] / Proc. Nat. Acad. Sci. USA   DOI   ScienceOn
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[ Cavicchia,J.C.;F.L.Sacerdote;L.Ortiz ] / Ultrastruc. Pathol   DOI   ScienceOn
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[ Chomczynski,P.;N.Sacchi ] / Anal. Biochem
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[ Karczewski,J.;J.Groot ] / Am. J. Physiol
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[ Bager,Y.;K.Kenne;V.Krutovskikh;M.Mesnil;O.Traub.;L.Warngard ] / Carcinogenesis   DOI   ScienceOn
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[ Cook,J.C.;M.A.Kaplan;L.G.Davis;J.C.O'Connor ] / Regul. Toxicol Pharmacol   DOI   ScienceOn
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[ Gray,L.E.Jr.;W.R.Kelce;T.Wiese;R.Tyl;K.Gaido;J.Cook;G.Klinefelter;D.Desaulniers;E.Wilson;T.Zacharewski;C.Waller;P.Foster;J.Laskey;J.Reel;J.Giesy;S.Laws;J.McLachlan;W.Breslin;R.Cooper;R.DiGiulio;R.Johnson;R.Purdy;E.Mihaich;S.Safe;T.Colborn ] / Reprod. Toxicol   DOI   ScienceOn
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[ Gow,A.;C.M.Southwood;J.S.Li;M.Pariali;G.P.Riordan;S.E.Brodie;J.Danias;J.M.Bronstein;B.Kachar;R.A.Lazzarini ] / Cell   DOI   ScienceOn
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[ Shimada,T.;K.Inoue;Y.Suzuki;T.Kawai;E.Azuma;T.Nakajima;M.Shindo;K.Kurose;A.Sugie;Y.Yamagishi;Y. Fujii-Kuriyama;M.Hashimoto ] / Carcinogenesis   DOI   ScienceOn
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[ Krizbai,I.A.;H.Bauer;A.Amberger;B.Hennig;H.Szabo;R.Fuchs;H.C.Bauer ] / Eur. J. Cell Biol.   DOI   ScienceOn
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[ Mullin,J.M.;K.V.Laughlin;N.Ginanni;C.W.Marano;H.M.Clarke;A.Peralta Soler ] / Ann. N.Y. Acad. Sci.   DOI
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[ Santomauro,L.;P.Corsi;A.Leone;G.Brescia;L.Roncali;B.Nico;M.Pisoni;F.Brizzi;G.Assennato;G.Elia ] / Med. Lav.
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[ Savettieri,G.;I.Di Liegro;C.Catania;L.Licata;G.L.Pitarresi;S.D'Agostino;G.Schiera;V.De Caro;G.Giandalia;L.I.Giannola;A.Cestelli ] / Neuroreport   DOI   ScienceOn
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[ Chung,N.P.;C.Y.Cheng ] / Endocrinology
37 Molecular physiology and pathophysiology of tight junctions.Ⅳ. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells /
[ Nusrat,A.;J.R.Turner;J.L.Madara ] / Am. J. Physiol.
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[ Ruch,R.J.;J.E.Klaunig;M.A.Pereira ] / Toxicol Appl. Pharmacol   DOI   ScienceOn
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[ Lippoldt,A.;A.Jansson;U.Kniesel;B.Andbjor;A.Andersson;H.Wolburg;K.Fuxe;H.Haller ] / Brain Res.   DOI
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[ Krutovskikh,V.A.;M.Mesnil;G.Mazzoleni;H.Yamasaki ] / Lab. Invest.
41 Complex phenotype of mice lacking occludin, a component of tight junction strands /
[ Saitou,M.;M.Furuse;H.Sasaki;J.D.Schulzke;M.Fromm;H.Takano;T.Noda;S.Tsukita ] / Mol. Biol. Cell   DOI
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[ Zolotarevsky,Y.;G.Hecht;A.Koutsouris;D.E.Gonzalez;C.Quan;J.Tom;R.J.Mrsny;J.R.Turner ] / Gastroenterology   DOI   ScienceOn
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[ Syed,V.;W.Gu;N.B.Hecht ] / J. Androl.
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[ Gye,M.C.;Y.H.Lee;C.Kim;M.K.Kim;H.Lee ] / Devel. Reprod   과학기술학회마을
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[ Morita,K.;H.Sasaki;K.Fujimoto;M.Furuse;S.Tsukita ] / J. Cell Biol.   DOI   ScienceOn
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[ Lui,W.Y.;W.M.Lee;C.Y.Cheng ] / Endocrinology   DOI
47 Developmental and hormonal regulation of the expression of oligodendrocyte-specificprotein/claudin 11 in mouse testis /
[ Hellani,A.;J.Ji;C.Mauduit;C.Deschildre;E.Tabone;M.Benahmed ] / Endocrinology   DOI   ScienceOn
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[ O'Connor,J.C.;J.C.Cook;T.W.Slone;G.T.Makovec;S.R.Frame;L.G.Davis ] / Toxicol Sci.   DOI   ScienceOn
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[ Park,Y.I.;J.S.So;S.C.Koh ] / J. Microbiol. Biotechnol.   과학기술학회마을
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[ Raychoudhury,S.S.;A.F.Flowers;C.F.Millette;M.F.Finlay ] / J. Androl
51 Claudin-1 and -2;Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin /
[ Furuse,J.;K.Fujita;T.Hiiragi;K.Fujimoto;S.Tsukita ] / J. Cell Biol.   DOI   ScienceOn
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[ Kang,K.S.;G.X.Li;J.S.Park;B.J.Lee;J.H.Che,J.H.Tae;J.J.Cho;S.H.Kim;D.S.Lee;Y.S.Lee ] / J. Microbiol. Biotechnol.   과학기술학회마을
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[ Tsai,M.L.;K.Cesen-Cummings;R.C.Webb.;R. Loch-Caruso ] / Toxicol Appl. Pharmacol   DOI   ScienceOn