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Cystocin, a Novel Antibiotic, Produced by Streptomyces sp. GCA0001: Production and Characterization of Cystocin  

Sohng, Jae-Kyung (Division of Natural Science, SunMoon University)
Lee, Hei-Chan (Chemical and Material Engineering, SunMoon University)
Liou, Kwang-Kyoung (Division of Natural Science, SunMoon University)
Lee, Eui-Bok (GeneChem Inc., Daeduk Bio Community)
Kang, Sun-Yub (GeneChem Inc., Daeduk Bio Community)
Woo, Jin-Suk (GeneChem Inc., Daeduk Bio Community)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.4, 2003 , pp. 483-486 More about this Journal
Abstract
3'-[S-Methyl-cysteinyl]-3'-amino-3'-deoxy-N,N- dimethyl adenosine, cystocin, is a biosynthesized antibiotic material newly identified from Streptomyces sp. GCA0001. Its structure was found to be similar to puromycin, where the terminal tyrosine is replaced by a methyl cysteine. NMR data prove that the 3-ammo ribose is connected to dimethylaminopurine through the anomeric carbon at 1'-carbon. The methyl cysteinyl unit is connected to the amino unit of ribose by peptide bond. The verification of the structure was performed by comparing the puromycin nucleosides resulted from the hydrolysis of cystocin and puromycin, respectively. Antibiotic activity of cystocin against Streptococcus was found to be two times more potent than that of puromycin.
Keywords
Cystocin; 3′-[S-methyl-cysteinyl]-3′-amino-3′-deoxy-N,N-dimethyl adenosine; puromycin; antibiotic activity; Streptomyces;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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