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Growth Inhibition and Apoptosis Induction of Gastric Cancer Cells by Copper (II) Glycinate Complex  

JE CHUL LEE (Department of Microbiology, Eulji University School of Medicine)
JEONG, YONG WOOK (Department of Microbiology, College of Medicine, Seonam University)
KISUNG KIM (Department of Microbiology, College of Medicine, Seonam University)
JAE YOUNG OH (Department of Microbiology, College of Medicine, Seonam University)
JONG CHUN PARK (Department of Microbiology, College of Medicine, Seonam University)
JUNG HWAN BANG (Department of Environmental Health, Seonam University)
ANG WON CHOI (Department of Chemistry, Yosu National University)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.3, 2003 , pp. 394-399 More about this Journal
Abstract
The in vitro cytotoxic effects of newly synthesized copper (II) glycinate complex were investigated in two gastric cancer cell lines of SNU484 and SNU638 cells. The complex inhibited the growth and decreased the viability of both gastric cancer cells in a dose-dependent manner. Gastric cancer tells treated with the complex exhibited the features of apoptosis, as demonstrated by fragmentation of chromosomal DNA, activation of caspase-3-like enzyme, and cleavage of poly［ADP-ribose］ polymerase (PARP). With the treatment of copper (II) glycinate complex, the active form of caspase-3 was observed in SNU484 cells, but not in SNU638 cells, indicating that an alternative pathway of apoptosis might have been triggered in SNU638 cells. In conclusion, copper (II) glycinate complex induces apoptosis of SNU484 and SNU638 gastric cancer cells, and it is suggested that novel copper (II) glycinate complex is highly active against human gastric cancer cells.
Keywords
Copper (II) glycinate complex; apoptosis; caspase; gastric cancer;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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