Browse > Article

In Vitro Immunopotentiating Activity of Cellular Components of Lactococcus lactis ssp. lactis  

Kim, Ji Yeon (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University)
Lee, Seong-Kyu (Department of Applied Biological Chemistry, The University of Tokyo)
Ciiimura, Satoshi-Ha (Department of Applied Biological Chemistry, The University of Tokyo)
Kaminogawa, Shuichi (Department of Applied Biological Chemistry, The University of Tokyo)
Lee, Hyong-Joo (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.2, 2003 , pp. 202-206 More about this Journal
Abstract
To determine the effect of immunopotentiating activity of cellular components of Lactococcus lactis ssp. lactis, the immune function was analyzed in vitro using mice cells. When stimulated with mitogens, productions of $IFN-{\gamma}$, IL-12, $TNF-{\alpha}$, and IL-6 were enhanced in spleen cells treated with cellular components, with IL-4 production being the highest in spleen cells treated with cytoplasm fraction. Without mitogen stimulation, the productions of $IFN-{\gamma}$ and IL-12 were the highest in spleen cells treated with heat-killed whole cell. $TNF-{\alpha}$ and IL-6 productions were also high in spleen cells treated with all cellular components. Only heat-killed whole cell showed significant enhancement in natural killer cell activity. In peritoneal exudates cells, $TNF-{\alpha}$ production was enhanced significantly by all cellular components of Lactococcus lactis ssp. lactis These results indicate that the cellular components of Lactococcus lactis ssp. lactis are capable of stimulating immune cells to produce cytokines, and that both their cell walls and cytoplasm fraction contribute to these capacities.
Keywords
Cell wall; cytoplasm; immune; Lactococcus lactis ssp. lactis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
연도 인용수 순위
1 Proinflammatory cytokine and nitric oxide induction in murine macrophages by cell wall and cytoplasmic extracts of lactic acid bacteria /
[ Tejada-Simon, M. V.;J. J. Pestka ] / J. Food Prot.
2 Health and nutritional benefits from lactic acid bacteria /
[ Gilliland, S. E. ] / FEMS Microbiol Rev.   DOI   ScienceOn
3 Antitumor activity of Lactobavillus casei in mice /
[ Kato, I. ;S. Kobayash;T. Yokokura;M. Mutrai ] / Jpn. J. Cancer Res.
4 Cytoskeleton reorganization and cytokine production of macrophages by bifidobacterial cells and cell-free extracts /
[ Lee, M. J.;Z. Zang;E. Y. Choi;H. K. Shin;G. E. Ji ] / J. Micrbiol. Biotechnol.   과학기술학회마을
5 Enhancement of natural and aquired immunity by Lactobavillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019) /
[ Gill, H. S.;K. J. Rutherfurd;J. Prasad;P. K. Gopal ] / Br. J. Nutr.   DOI   ScienceOn
6 The role of T cell growth stimulating factors in T cell triggering /
[ Gronvik, K. O.;J. Andersson ] / Immunol. Rev.   DOI
7 Characterization of a water-soluble polysaccharide fraction with immunopotentiating activity from Bifidbacterium adolescentis M101-4 /
[ Hosono, A.;J. Lee;A. Ametani;M. Natsume;M. Hirayama;T. Adachi;S. Kaminogawa ] / Biosci. Biotechnol. Biochem.   DOI   ScienceOn
8 Positive correlation correlation between in vitro NK activity and in vivo resistance towards AKR lymphoma cells /
[ Riesenfeld, I.;A. Orn;M. Gidlung;I. Axberg;G. V. Alm;H. Wigzell ] / Int. J. Cancer   DOI
9 Role of natural killer cells in tumor growth and metastasis: C57BL/6 normal and beige mice /
[ Talmadge, J. E.;K. M. Meyers;D. J. Prieur;J. R. Starkey ] / J. Natl. Cancer Inst.
10 Selective depletion of NK cell activity in vivo and its effect on the growth of NK-sensitive and NK-resistant tumor variants /
[ Kawase, I.;C. L. Urdal;C. G. Brooks;C. S. Henney ] / Int. J. Cancer   DOI
11 Regulation of T-cell activation: Differences among T-cell subsets /
[ Gajewski, T. F.;S. R. Schell;G. Nau;F. W. Fitch ] / Immunol. Rev.   DOI
12 Comparison of the TNF-α levels induced by human-derived Bifidobacterium longum and rat-derived Bifidobavterium animalis in mouse peritoneal cells /
[ Sekine, K.;T. Kawashima;Y. Hashimoto ] / Bifidobacteria microflora
13 Role of natural killer cells in the destruction of circulating tumor emboli /
[ Hanna, N.;I. J. Fidler ] / J. Natl. Cancer Inst.
14 Protective and therapeutic efficacy of Lactobacillus casei against experimental murine infections due to Mycobavterium fortuitum complex /
[ Saito, H.;H.Tomioka;K. Nagashima ] / J. Gen. Microbiol.
15 Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors /
[ Herberman, R. B.;M. E. Nunn;H. T. Holden;D. H. Lavrin ] / Int. J. Cancer   DOI
16 Enhancement of immune response in Peyer's patch cells cultured with Bifidobacteriumbreve /
[ Yasui, H.;M. Ohwaki ] / J. Dairy Sci.   DOI   ScienceOn
17 Natural cytotoxic cells against solid tumor in mice /
[ Lattime, E. C.;G. A. Pecoraro;O. Stutman ] / J. Immunol.
18 Salmonella infection of bone marrow-derived macrophages and dendritic cells: Influence on antigen presentation and initiating an immune response /
[ Yrlid, U.;M. Svensson;C. Johansson;M.J. Wick ] / FEMS Immunol. Med. Microbiol.   DOI   ScienceOn
19 Effect of perorally admonistered lactobacilli on macrophage activation in mice /
[ Perdigon, G.;M. E. Nader de Macias;S. Alvarez;G. Oliver;A.A. Pesce de Ruiz Holgado ] / Infect. Immun.
20 Immune response of mice to orally administered lactic acid bacteria /
[ Takahashi, R.;R. Oka;H. Iwana;T. Kuwata;Y. Yamamoto ] / Biosci. Biotechnol. Biochem.   DOI
21 In vivo natural reactivity of mice against tumor cells /
[ Riccardi, C.;A. Santoni;T. Barlozzari;P. Puccetti;R. B. Herberman ] / Int. J. Cancer.   DOI
22 Cytokines in cancer therapy /
[ Parmiani, G.;L. Rivoltini;G. Andreola;M. Carrabba ] / Immunol. Lett.   DOI   ScienceOn
23 Enhancement of immune response in mice fed with Streptococcus thermophillus and Lactobavillus acidophilus /
[ Perdigon, G;M. E. Nader de Macias;S. Alvarez;M. Medici;G. Oliver;A. A. Psece de Ruiz Holgado ] / J. Darity Sci.   DOI   ScienceOn
24 Enhancement by interferon of natural killer cell activity in mice /
[ Senik, A.;I. Gresser;C. Maury;M. Gidlund;A. Orn;H. Wigzell ] / Cell. Immunol.   DOI   ScienceOn
25 Intravenous immunoglobulins suppress the recurrences of genital herpes simplex virus: A clinical and immunological study /
[ Masci, S.;C. De Simone;G. Facularo;M. Gravante;M. Ciancarelli;M.Andreassi;P. Amerio;G. Santini ] / Immunopharmacol. Immunotoxicol.   DOI   ScienceOn
26 Effects of Lactobacillus ssp. on cytokine production by RAW 264.7 mactophages and EL-4 thymoma cell lines /
[ Marin, M. L.;M.V. Tejada-Simon;J. Murtha;Z. Ustunol;J. J. Pestka ] / J. Food Prot.