Browse > Article

Transformation of Ginsenosides to Compound K(IH-901) by Lactic Acid Bacteria of Human Intestine  

Bae, Eun-Ah (Department of Food and Nutrition, Kyung-Hee University)
Kim, Na-Young (Department of Food and Nutrition, Kyung-Hee University)
Han, Myung-Joo (Department of Food and Nutrition, Kyung-Hee University)
Choo, Min-Kyung (College of Pharmacy Kyung-Hee University)
Kim, Dong-Hyun (College of Pharmacy and East-West Mecical Research Institute, Kyung Hee University)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.1, 2003 , pp. 9-14 More about this Journal
Abstract
When ginsenosides Rbl, Rb2, and Rc were anaerobically incubated with commercial and human intestinal lactic acid bacteria, most commercial lactic acid bacteria did not metabolize these ginsenosides to compound K. However, lactic acid bacteria, B. minimum KK-1, Bifidobacterium cholerium KK-2, and B. cuniculi K-513, isolated from human intestinal microflora transformed these ginsensosides to compound K. When the bacterial mixtures of commercial lactic acid bacteria were incubated with these ginsenosides, these compounds were not transfformed to compound K. However, when Bzfidobacterium KK-1 and KX-2 were miked, these ginsenosides were synergistically transformed to compound K. When water extract of ginseng was incubated with these mixed bifidobacteria, compound K was potently produced. Therefore, it is suggested that, if ginseng with these mixed bifidobacteria is fermented, compound K-enforced ginseng materials could be produced that show cytotoxicity against tumor cell lines.
Keywords
Ginsenosides; lactic acid bacteria; compound K; cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration measurement of compound K by enzyme immunoassay /
[ Akao T.;M. Kanaoka;K. Kobashi ] / Biol. Pharm. Bull.   DOI   ScienceOn
2 Constitutive <TEX>${\beta}$</TEX>-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria /
[ Bae E. A.;S. Y. Park;D. H. Kim ] / Biol. Pharm. Bull.   DOI   ScienceOn
3 Studies on absorption, distribution, excretion and metabolism of ginseng saponins, VII Comparison of the decomposition modes of ginsenoside Rb1 and Rb2 in the digestive tract of rats /
[ Karikura M.;T. Miyaze;H. Tanizawa;T. Taniyzma;Y. Takino ] / Chem. Pharm. Bull.
4 Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing /
[ Carmichael J.;W. G. DeGreff;A. F. Gazdar;J. D. Minna;J. B. Mitchell ] / Cancer Res.
5 Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponis /
[ Hasegawa H.;J. W. Sung;Y. Benno ] / Planta Medica   DOI   ScienceOn
6 Studies on the enzyme immunoassay of bioactive constituents contained in oriental medicinal drugs, VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng /
[ Kanaoka M.;H. Kato;F. Shimada;S. Yano ] / Chem. Pharm. Bull.   DOI   ScienceOn
7 In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration /
[ Wakabayashi C.;H. Hasegawa;J. Murata;I. Saiki ] / Oncol. Res.
8 Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities /
[ Bae E. A.;M. J. Han;M. K. Choo;S. Y. Park;D. H. Kim ] / Biol. Pharm. Bull.   DOI   ScienceOn
9 Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng /
[ Akao T.;H. Kida;M. Kanaoka;M. Hattori;K. Kobashi ] / J. Pharm. Pharmacol   DOI   ScienceOn
10 Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin /
[ Lee S. J.;J. H. Sung;S. J. Lee;C. K. Moon;B. H. Lee ] / Cancer Lett.   DOI   ScienceOn
11 Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng - Ginsenoside Rb2 /
[ Sato K.;M. Mochizuki;I. Saiki;Y. C. Yoo;K. Samukawa;I. Azuma ] / Biol. Pharm. Bull   DOI   ScienceOn
12 Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R) and 20(S)-ginsenoside Rg3 of Red ginseng /
[ Mochizuki M.;C. Y. Yoo;K. Matsuzawa;K. Sato;I. Saiki;S. Tonooka;K. Samukawa;I. Azuma ] / Biol. Pharm. Bull.   DOI   ScienceOn
13 Saponin adjuvant enhancement of antigenspecific immune responses to an experimental HIV-1 vaccine /
[ Wu J. Y.;B. H. Gardner;C. I. Murphy;J. R. Seals;C. R. Kensil;J. Recchia;G. A. Beltz;G. W. Newman;M. J. Newman ] / J. Immunol
14 Metabolism of ginseng saponins, ginsenosides by human intestinal bacteria /
[ Kanaoka M.;T. Akao;K. Kobashi ] / J. Tradit. Med.
15 Isolation of nisin-producing Lactobacillus lactis strain from Kimchi and characterization of its nisZ gene /
[ Lee K. H.;G. S. Moon;J. Y. An;H. J. Lee;H. C. Chang;D. K. Chung;J. H. Lee;J. K. Kim ] / J. Microbiol. Biotechnol.   과학기술학회마을
16 Physiological responses of oxygen-tolerant anaerobic Bifidobacterium longum under oxygen /
[ Kim D. W.;H. J. Hwang;K. H. Park. ] / J. Microbiol. Biotechnol.   과학기술학회마을
17 Chemical studies on the oriental plant drugs. XXVIII, Saponins and sapogenins of ginseng, Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc /
[ Tanaka N.;O. Tanaka;S. Shibata ] / Chem Pharm. Bull.   DOI