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Biotransformation of a Fungicide Ethaboxam by Soil Fungus Cunninghamella elegans  

PARK, MI-KYUNG (School of Agricultural Biotechnology, Seoul national University)
KWANG-HYEON LIU (Department of Pharmacology, Inje university College of Medicine)
YOONGHO LIM (Department of Pharmacology, Inje university College of Medicine)
YOUN-HYUNG LEE (Plant Metabolism Research Center, Kyung Hee University)
HOR-GIL HUR (Department of Environmental Science & Engineering, Kwangju Institute of Science & Technology)
JEONG-HAN KIM (School of Agricultural Biotechnology, Seoul national University)
Publication Information
Journal of Microbiology and Biotechnology / v.13, no.1, 2003 , pp. 43-49 More about this Journal
Abstract
Metabolism of a new fungicide ethaboxam by soil fungi was studied. Among the fungi tested, Cunninghamelia elegans produced metabolites from ethaboxam, which were not found in the control experiments. M5, a major metabolite from ethaboxam was firmly identified as N-deethylated ethaboxam by LC/MS/MS and NMR. N-Deethylated ethaboxam has been found as a single metabolite in in vitro metabolism with rat liver microsomes. Ml was proved to be 4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide (ETC) by comparing with the authentic compound. In addition, M2, M3, and M4, and M6 were tentatively Identified by LC/MS/MS as hydroxylated and methoxylated ethaboxams, respectively. Production of the major metabolite, N-deethylated ethaboxam, by the fungus suggested that C. elegans would be an efficient eukaryotic microbial candidate for evaluating xenobiotic-driven mammalian risk assessment.
Keywords
Ethaboxam; Cunninghamella elegans; metabolism; fungicide;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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