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Hypolipidemic Effect of Exo- and Endo-Biopolymers Pmduced from Submerged Mycelial Culture of Ganoderma lucidum in Rats  

Yang, Byung-Keun (Research Center for Processing & Application of Agricultural Products, Daegu University)
Jeong, Sang-Chul (Department of Biotechnology, Daegu University)
Song, Chi-Hyun (Department of Biotechnology, Daegu University)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.6, 2002 , pp. 872-877 More about this Journal
Abstract
The hypolipidemic effect of the exe-biopolymer (EXBP) and endo-biopolymer (ENBP) produced from a submerged mycelial culture of Ganoderma lucidum was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were achieved in both the EXBP- and ENBP-treated groups, however, the former proved to be more potent than the latter. The administration of the EXBP (100 mg/kg body weight) substantially reduced the plasma total cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, phospholipid levels, and atherogenic index by 31.0, 39.0, 35.4, 28.1, and 53.5%, respectively, when compared to the control group. The EXBP also lowered the liver total cholesterol, triglyceride, and phospholipid levels by 22.4, 23.1, and 12.9%, respectively. Furthermore, the high-density lipoprotein (HDL) cholesterol and ratio of HDL cholesterol to total cholesterol were significantly increased by as much as 24.2% and 47.6%, respectively.
Keywords
Exo-and endo-biopolymers; hypolipidemic effect; Ganoderma lucidum; submerged mycelial culture;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
Times Cited By Web Of Science : 11  (Related Records In Web of Science)
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