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In Vitro Bactericidal and Anticancer Activity of New Metabolite, ARK42, Isolated from Aspergillus repens K42  

Park, Je-Won (Graduate School of Biotechnology, Korea University)
Song, Beom-Seok (Graduate School of Biotechnology, Korea University)
Ryu, Do-Jin (Department of Food science and Technology, University of Nebraska)
Lee, Chan (Department of Food Science and Technology, Chung-Ang University)
Kim, Young-Bae (Graduate School of Biotechnology, Korea University)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.6, 2002 , pp. 1017-1021 More about this Journal
Abstract
A novel antibacterial metabolite, ARK42, was elated from a xerophilic fungal strain K42, and Identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and $3.125{\mu}g/ml$, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of $12.5{\mu}g/ml$. Furthermore, anticancer activities were demonstrated against human colon cancer DLD- 1 and lung cancer LXFL529 cells with an $IC_50$ of 10 and $1{\mu}g/ml$, respectively.
Keywords
Aspergillus repens; bactericidal activity; anti-cancer activity;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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