[KSCI] Korea Science Citation Index Service

Evaluation of Antimicrobial Activity of Farnesoic Acid Derivatives

Kim, Sang-Hee (Natural Products Research Institute, College of Pharmacy, Seoul national University)
Oh, Ki-Bong (Natural Products Research Institute, College of Pharmacy, Seoul national University, Graduate School of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University)

Publication Information

Journal of Microbiology and Biotechnology / v.12, no.6, 2002 , pp. 1006-1009 More about this Journal

Abstract

The biological activities of farnesoic acid derivatives against pathogenic fungi and bacteria were investigated. Farnesoic acid and its derivatives showed growth inhibitory activities against various bacteria. Among the compounds tested, geranylgeranoic acid (3) had potent antibacterial activity against Salmonella typhimurium, Proteus vulgaris, and Bacillus subtilis with minimum inhibitory concentration (MIC) in the range of $6.25-12.5{\mu}g/ml$ . On the other hand, amide derivatives of farnesoic acid showed some antifungal activities. In particular, 3,7,11-trimethyl-dodeca-2,6,10-trienoic acid amide (5a) had a potent antifungal activity against Aspergillus niger, Candida albicans, and Trichophyton sp. with MIC in the range of $6.25-12.5{\mu}g/ml$ .

Keywords

Farnesoic acid derivatives; antimicrobial activity; MIC;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)
Times Cited By Web Of Science : 6 (Related Records In Web of Science)

Reference
Cited By KSCI

1	Farnesol wxidation in insects: Evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase / [ Sperry,A.E.;S.E.Sen ] / Insect. Biochem. Mol. Biol. DOI ScienceOn
2	Creating isoprenoid diversity / [ Sacchettini,J.C.;C.D.Polter ] / Science. DOI
3	Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane / [ Wu,M.;R.E.W.Hancocks ] / J. Biol. Chem. DOI ScienceOn
4	Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway / [ Edwards,P.A.;j.Ericssion ] / Annu. Rev. Biochem. DOI ScienceOn
5	Farnesol.stimulates differentiation in epidermal keratinocytes via PPAR / [ Hanley,K.;L.G.Konuves;D.C.Ng;K.Schoonjans;S.S.He;P.Lau;D.D.Bikle;M.L.Williams;P.M.Elias;J.Auwerx;K.R.Feingold ] / J. Biol. Chem. DOI ScienceOn
6	Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism / [ Kim,S.Y.;C.Kim;I.S.Han;S.C.Lee;S.H.Kim;K.S.Lee;Y.Choi;Y.Byun ] / Metabolism. DOI ScienceOn
7	/ [ AOAC ] / Official Methods of Analysis of AOAC International (16th ed.)
8	Sterols and gene expression: control of affluence / [ Schoonjans,K.;C.Brendel;D.Mangelsdorf;J.Auwerx ] / Biochim. Biophys. Acta DOI ScienceOn
9	Control of filament formation in Candida albicans by the transcriptional repressor TUP1 / [ Brown,B.R.;A.D.Johnson ] / Science.
10	Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans / [ Oh,K.B.;H.Miyazawa;T.Naito;H.Matsuoka ] / Proc. Natl. Acad. Sci. USA DOI ScienceOn
11	Effects of geranylgeranoic acid in bone: Induction of osteoblast differentiation and inhibition of osteoclast formation / [ Wang,X.;J.Wu;Y.Shidoji;Y.Muto;N.Ohishi;K.Yagi;S.Ikegami;T.Shinki;N.Udagawa;T.Suda;Y.Ishimi ] / J. Bone Miner. Res. DOI ScienceOn
12	Reference method for broth dilution antifungal susceptibility testing of yeasts; Proposed standard / [ National Committee for Clinical laboratory Standards;National Committee for Clinical laboratory Standards (ed.) ] / NCCLS Document M27-P
13	Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism / [ Kim,S.;E.Kim;D.S.Shin;H.Kang;K.B.Oh ] / Bioorg. Med. Chem. Lett. DOI ScienceOn
14	IL-6 mRNA expression in mouse macrophages and NIH 3T3 fibroblasts in response to Candida albicans / [ Lee,Y.S.;H.S.Kim;S.K.Kim;S.D.Kim ] / J. Microbiol. Biotechnol. 과학기술학회마을
15	In vitro activities of 2,2-dipyridyl against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis / [ Ryu,J.S.;D.Y.Min;M.C.Kim;N.S.Kim;M.H.Shin ] / J. Microbiol. Biotechnol. 과학기술학회마을