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Antimicrobial Effects of Ocotillone Isolated from Stem Bark of Ailanthus altisshima  

Lee, Dong-Gun (Research Center for Proteineous Materials, Chosun University)
Chang, Young-Su (College of Pharmacy, Chosun University, Research Center for Proteineous Materials, Chosun University)
Park, Yoon-Kyung (Research Center for Proteineous Materials, Chosun University)
Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University)
Woo, Eun-Rhan (College of Pharmacy, Chosun University, Research Center for Proteineous Materials, Chosun University)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.5, 2002 , pp. 854-857 More about this Journal
Abstract
Bioassay-directed chromatographic fractionation of a methylene chloride extract of Ailanthus altisshima indicated the presence of 20(S), 24(R), epoxy-25-hydroxydammarane-3-one (compound 1, ocotillone) which was isolated from this plant, for the first time. Antimicrobial activity of compound 1 was measured by inhibition of bacterial and fungal cells growth and by a hemolytic assay with human erythrocytes, respectively. The results revealed that compound 1 had potent antibacterial activity against Cram-negative bacteria, P. aeruginosa and S. typhimurium, that were without hemolytic activity, whereas it had weak antimicrobial activity against Gram-positive bacteria and fungi. These results demonstrated that the compound 1 has more antibacterial activity against 6ram-negative bacteria, which have no hemolytic activity, than Gram-positive bacteria and fungi. This is the first report on the biological activities of the compound 1.
Keywords
Antibiotic activity; Ailanthus altisshima; ocotillone;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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