Browse > Article

PC-766B' and PC-766B, 16-Membered Maerolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56  

Ko, Hack-Ryong (Antibiotics Laboratory, RIKEN)
Kakeya, Hideaki (Antibiotics Laboratory, RIKEN)
Yoshida, Arika (Antibiotics Laboratory, RIKEN/Graduate School of Science and Engineering, Saitama University)
Onose, Rie (Antibiotics Laboratory, RIKEN)
Ueki, Masashi (Antibiotics Laboratory, RIKEN)
Muroi, Makoto (Animal and Cellular System Laboratory, RIKEN)
Takatsuki, Akira (Animal and Cellular System Laboratory, RIKEN)
Matsuzaki, Hiroshi (Graduate School of Science and Engineering, Saitama University)
Osada, Hiroyuki (Antibiotics Laboratory, RIKEN/Graduate School of Science and Engineering, Saitama University)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.5, 2002 , pp. 829-833 More about this Journal
Abstract
Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of this event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesls, PC-766B' (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic activities. PC-766B' (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor (VEGF).
Keywords
Angiogenesis inhibitor; macrolide; Nocardia sp.;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
연도 인용수 순위
1 Folmycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus. /
[ Muroi. M.;N. Shiragami;K. Nagao;M. Yamasaki;A. Takatsuki. ] / Cell Struct. Func.   DOI   ScienceOn
2 PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. Ⅰ. Taxonomy, fermentation and biological antivity. /
[ Kumagai, K.;A. Fukui;S. Tanaka;M. Ikemoto;K. Moriguchi;S. Nabeshima. ] / J. Antibiot.   DOI   ScienceOn
3 Micromonospolide A, a new macrolide from Micromonospora sp. /
[ Ohta, E.;S. Ohta;N. K. Kubota;M. Suzuki;T. Ogawa;A. Yamasaki;S. Ikegami. ] / Tetrahedron Lett.   DOI   ScienceOn
4 Progress in antiangiogenic gene therapy fo cancer. /
[ Feldman, A. L.;S. K. Libutti. ] / Cancer
5 Bafilomycins: A class of inhibitors of membrane ATPase from microorganisms, animal cells, and plant cells. /
[ Bowman, E. J.;A. Siebers;K. Altendorf. ] / Proc. Natl. Acad. Sci. USA   DOI   ScienceOn
6 Novel antibiotic PC-776B manufacture with Nocardia. /
[ Kumagai, K.;K. Tays;S. Tanaka;K. Moriguchi;M. Fukasawa;A. Fukui. ] / Jpn Kokai 5990
7 Metabolic products of microorganisms. 224. Bacfilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. /
[ Werner, G.;H. Hagenmaier;H. Drautz;A. Baumgartner;H. Zahner. ] / J. Antibioti.   DOI
8 The utilizaton of carbon compounds by some Actinomycetales as an aid for species determination. /
[ Pridham, T. G.;D. Gottlieb. ] / J. Bacteriol.
9 Factors promoting tumor angiogenesis. /
[ Beckner, M. E. ] / Cancer Invest.   DOI   ScienceOn
10 Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. /
[ Hanahan, D.;J. Folkman. ] / Cell
11 Distribution of menaquinones in actinomycetes and corynebacteria. /
[ Collins, M. D.;T. Pirouz;M. Goodfellow;D. E. Minnikin. ] / J. Gen. Microbiol.   DOI   ScienceOn
12 The structure of leucanicidin, a novel insecticidal macrolide produced by Streptomyces halstedii. /
[ Isogai, A.;S. Sakuda;S. Matsumoto;M. Ogura;K. Furhata;H. Seto;A. Suzuki. ] / Agric. Biol. Chem.
13 The structure of the bafilomycins, a new group of macrolide antibiotics. /
[ Werner, G.;H. Hagenmaier;K. Albert;H. Kohlshorn;H. Drautz. ] / Tetrahedron Lett.   DOI   ScienceOn
14 Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoprotein. /
[ Muroi, M.;A. Takasu;M. Yamasaki;A. Takatsuki. ] / Biochem. Biophys. Res. Commun.   DOI   ScienceOn
15 The structure of a new antibiotic, hydrolidin. /
[ Seto, H.;H. Akao;K. Furihata;N. Otake. ] / Tetrahedron Lett.   DOI   ScienceOn
16 Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites. /
[ Kakeya, H.;R. Onose;H. Koshino;A. Yoshida;K. Kobayashi;S.-I. Kageyama;H. Osada. ] / J. Am. Chem. Soc.   DOI   ScienceOn
17 Azaspirene: A novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp. /
[ Asami, Y.;H. Kakeya;R. Onose;A. Yoshida;H. Matsuzaki;H. Osada. ] / Org. Lett.   DOI   ScienceOn
18 Isolation and characterization of concanamycins A, B and C. /
[ Kinashi, H.;K. Someno;K. Sakaguchi. ] / J. Antibiot.   DOI
19 Chemical composition of cell-wall preparation from strains of from-genera of aerobic actinomycetes. /
[ Becker, B.;M. P. Lechevalier;H. A. Lechevalier. ] / Appl. Microbiol.
20 Structural determination of a new naturally occurring cyclic vitamin. /
[ Howarth, O. W.;E. Grund;R. M. Kroppenstedt;M. D. Collins. ] / Biochem. Biophys. Res. Commun.   DOI   ScienceOn
21 Methods for characterization of Streptomyces species. /
[ Shirling, E. B.;D. G Gottlieb. ] / Int. J. Syst, Bacteriol.   DOI
22 Molecular angiogenesis. /
[ Klagsbrun, M.;M. A. Moses. ] / Chem. Biol.   DOI   ScienceOn
23 PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. Ⅱ. Isolation, physicochemical properties and structure elucidation. /
[ Kumagai, K.;A. Fukui;S. Tanaka;M. Ikemoto;K. Moriguchi;S. Nabeshima. ] / J. Antibiot.   DOI   ScienceOn