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http://dx.doi.org/10.1080/12298093.2020.1744955

Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters  

Won, Eun Jeong (Department of Laboratory Medicine, Chonnam National University Medical School)
Joo, Min Young (Department of Laboratory Medicine, Chonnam National University Medical School)
Lee, Dain (Department of Laboratory Medicine, Chonnam National University Medical School)
Kim, Mi-Na (Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center)
Park, Yeon-Joon (Department of Laboratory Medicine, The Catholic University of Korea College of Medicine)
Kim, Soo Hyun (Department of Laboratory Medicine, Chonnam National University Medical School)
Shin, Myung Geun (Department of Laboratory Medicine, Chonnam National University Medical School)
Shin, Jong Hee (Department of Laboratory Medicine, Chonnam National University Medical School)
Publication Information
Mycobiology / v.48, no.2, 2020 , pp. 148-152 More about this Journal
Abstract
We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.
Keywords
Aspergillus fumigatus; antifungal susceptibility; cyp51A/cyp51B; multicentre;
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