[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5941/MYCO.2013.41.1.1

Msi1-Like (MSIL) Proteins in Fungi

Yang, Dong-Hoon (Department of Biotechnology, Center for Fungal Pathogenesis, College of Life Science and Biotechnology, Yonsei University)
Maeng, Shinae (Department of Biotechnology, Center for Fungal Pathogenesis, College of Life Science and Biotechnology, Yonsei University)
Bahn, Yong-Sun (Department of Biotechnology, Center for Fungal Pathogenesis, College of Life Science and Biotechnology, Yonsei University)

Publication Information

Mycobiology / v.41, no.1, 2013 , pp. 1-12 More about this Journal

Abstract

Msi1-like (MSIL) proteins, which are eukaryote-specific and contain a series of WD40 repeats, have pleiotropic roles in chromatin assembly, DNA damage repair, and regulation of nutrient/stress-sensing signaling pathways. In the fungal kingdom, the functions of MSIL proteins have been studied most intensively in the budding yeast model Saccharomyces cerevisiae, an ascomycete. Yet their functions are largely unknown in other fungi. Recently, an MSIL protein, Msl1, was discovered and functionally characterized in the pathogenic yeast Cryptococcus neoformans, a basidiomycete. Interestingly, MSIL proteins appear to have redundant and unique roles in both fungi, suggesting that MSIL proteins may have evolutionarily divergent roles in different parts of the fungal kingdom. In this review, we will describe the current findings regarding the role of MSIL proteins in fungi and discuss future directions for research on this topic.

Keywords

Chromatin assembly factor; Histone; Msi1; Retinoblastoma; WD40;

Citations & Related Records

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