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http://dx.doi.org/10.5941/MYCO.2012.40.2.142

Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus  

Yeom, Ji-Hee (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
Lee, In-Kyoung (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
Ki, Dae-Won (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
Lee, Myeong-Seok (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
Seok, Soon-Ja (National Institute of Agricultural Science and Technology, Rural Development Administration)
Yun, Bong-Sik (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
Publication Information
Mycobiology / v.40, no.2, 2012 , pp. 142-144 More about this Journal
Abstract
During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to $^1H$ NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with $IC_{50}$ values of 13.1 and 0.03 ${\mu}M$, respectively.
Keywords
Hispidin; Hypholomine B; Neuraminidase inhibitor; Phellinus linteus;
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Times Cited By KSCI : 2  (Citation Analysis)
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