[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5941/MYCO.2011.39.3.143

The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans

Kronstad, James W. (The Michael Smith Laboratories, Department of Microbiology and Immunology, Faculty of Land and Food Systems, University of British Columbia)
Hu, Guang-Gan (The Michael Smith Laboratories, Department of Microbiology and Immunology, Faculty of Land and Food Systems, University of British Columbia)
Choi, Jae-Hyuk (The Michael Smith Laboratories, Department of Microbiology and Immunology, Faculty of Land and Food Systems, University of British Columbia)

Publication Information

Mycobiology / v.39, no.3, 2011 , pp. 143-150 More about this Journal

Abstract

The basidiomycete fungus Cryptococcus neoformans is an important pathogen of immunocompromised people. The ability of the fungus to sense its environment is critical for proliferation and the generation of infectious propagules, as well as for adaptation to the mammalian host during infection. The conserved cAMP/protein kinase A pathway makes an important contribution to sensing, as demonstrated by the phenotypes of mutants with pathway defects. These phenotypes include loss of the ability to mate and to elaborate the key virulence factors capsule and melanin. This review summarizes recent work that reveals new targets of the pathway, new phenotypic consequences of signaling defects, and a more detailed understanding of connections with other aspects of cryptococcal biology including iron regulation, pH sensing, and stress.

Keywords

Cryptococcus neoformans; Signal transduction; Mating; Virulence;

Citations & Related Records

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