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http://dx.doi.org/10.4489/MYCO.2010.38.1.046

The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage  

Jo, Wol-Soon (Department of Microbiology, Dong-A University College of Medicine)
Choi, Yoo-Jin (Department of Microbiology, Dong-A University College of Medicine)
Kim, Hyoun-Ji (Department of Microbiology, Dong-A University College of Medicine)
Lee, Jae-Yun (Cheong-Won Farm)
Nam, Byung-Hyouk (Deartment of Microbiology, Pusan National University College of Natural Sciences)
Lee, Jae-Dong (Deartment of Microbiology, Pusan National University College of Natural Sciences)
Lee, Sang-Wha (Department of Microbiology, Dong-A University College of Medicine)
Seo, Su-Yeong (Department of Microbiology, Dong-A University College of Medicine)
Jeong, Min-Ho (Department of Microbiology, Dong-A University College of Medicine)
Publication Information
Mycobiology / v.38, no.1, 2010 , pp. 46-51 More about this Journal
Abstract
The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-$\alpha$ and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.
Keywords
Anti-inflammatory activity; Cordyceps militaris; Lipopolysaccharide; Nitric oxide; Pro-inflammatory cytokines; RAW 264.7 cell;
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